Urinary histamine and urine volume in man.
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Biomedical subjects
Publications and source records attributed to R G Mitchell.
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1. Histamine levels in whole blood and plasma from the umbilical arteries and veins, together with circulating basophil and eosinophil counts, were determined in two groups of healthy infants, "term" and "pre-term".2. No significant arteriovenous differences were found except in the basophil counts of the "pre-term" group. This result was consistent with the finding of significant arteriovenous correlations for all these sets of estimations except the basophil counts in the "pre-term" group.3. No significant differences were found between the mean values in either group except for the difference between the mean basophil counts for venous blood.4. Plasma histamine levels (arterial and venous) were usually less than the lowest limit of the method (1.8 ng/ml). Very small amounts of histamine were detected, however, in one venous and one arterial specimen in the "pre-term" group, but these did not produce a significant difference between the levels for the two groups of infants.
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Strains of Gram-positive, catalase-positive, coagulase-negative cocci isolated from urine specimens were classified by the system of Baird-Parker (1963). Urinary infections attributed to instrumentation or pathological abnormalities of the urinary tract were caused almost entirely by various Staphylococcus subgroups. These showed a wide range of antibiotic sensitivities, unrelated to subgroups and not obviously related to previous chemotherapy. Attacks of cystitis occurring in otherwise healthy women were usually caused by Micrococcus subgroup 3 strains.
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