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Biomedical subjects

R G Knight

Publications and source records attributed to R G Knight.

63 records · Page 4Linked to original sources
PubMed1979

A double blind comparison of thiothixene and a trifluoperazine/chlorpromazine composite in the treatment of chronic schizophrenia.

Thirty chronic schizophrenic patients participated in a double-blind crossover trial of thiothixene (Navane) and a control drug combination of trifluoperazine and chlorpromazine. No statistically significant difference was found between the two drug conditions on numerous behavioural scales. Experience with thiothixene suggested that it was comparable with control drugs in the activation of withdrawn patients but needs to be used in combination with a more sedative antipsychotic agent in the treatment of some paranoid patients.

Chlorpromazine↗
PubMed1978

Global capacity reduction and schizophrenia.

This paper reviews the evidence for a specific deficit in the flow of information through the schizophrenic processing system. It is suggested that there is little to support the notion of a single defective mechanism underlying schizophrenic cognitive dysfunction. The lack of a valid and reliable metric for measuring degree of difficulty across tasks and a lack of concern with matching tasks for attentional processing load, detracts from the usefulness of available results. The applicability of a global limited capacity model of selective attention to schizophrenic information processing is discussed as the most appropriate means of systematizing the wealth of published empirical data.

Arousal↗
PubMed1976

A double blind study of the antidepressants dibenzepin (Noveril) and amitriptyline.

The study undertook to compare the efficacy of dibenzepin and amitriptyline in the treatment of endogenous depression. The outcome of the study was that both drugs appear to be equally effective in the treatment of depression, but dibenzepin was more efficient in reducing associated anxiety. Both drugs are appropriate to the treatment of psychotic depression, and work equally rapid. There was also a tendency for dibenzepin to elicit less intense side effects.

Amitriptyline↗
PubMedDate not supplied

The relationship between social skill and family problem-solving following very severe closed head injury.

This study examined the relationship between level of social skill and family problem-solving behaviour in a group of 18, community dwelling, very severe closed head injury (CHI) patients who had suffered their injury at least 18 months previously, and who were still in contact with rehabilitation services. The main findings of this study were a positive relationship between CHI patients' level of social skill and their rate of positive effect, and an inverse relationship between the CHI patients' level of social skill and the rate of facilitative behaviour displayed by relatives during problem-solving interactions. It is suggested that socially unskilled CHI patients may be more demanding to interact with, and that this may cause a significant burden for their relatives.

Adult↗
PubMedDate not supplied

Post-traumatic amnesia and Glasgow Coma Scale related to outcome in survivors in a consecutive series of patients with severe closed-head injury.

A consecutive series of 93 severe closed-head injury (SCHI) patients, discharged from hospital in a conscious state, were rated on the Glasgow Outcome Scale at 6 and 12 months post-injury. Patients were included in this study if they had a period of post-traumatic amnesia (PTA) exceeding 24 h. Approximately 80% of patients had made a good recovery by 12 months post-injury; a better outcome than has been found in studies using the presence of coma during the first 6 h post-admission to hospital to define severe head injury. When analysed individually, duration of PTA and Glasgow Coma Scale scores on admission to hospital were both strongly correlated with outcome. Only duration of PTA, however, contributed significantly to outcome variance when potential outcome predictors were assessed using a stepwise multiple regression analysis. The definition of severe head injury, the higher than usual incidence of good recovery in the present study, and the relationship between injury severity and outcome are discussed.

Adolescent↗