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Biomedical subjects

R G Hart

Publications and source records attributed to R G Hart.

At least 127 records · Page 7Linked to original sources
PubMed1983

Acoustic tumors: atypical features and recent diagnostic tests.

About one-third of patients with acoustic tumor (AT) initially seek medical attention for nonaudiologic complaints. The nonspecific early symptoms of AT require the inclusion of AT in many neurologic differential diagnoses. Advances in electrophysiologic and radiographic tests have allowed earlier diagnosis of AT at a time when abnormal physical findings other than hearing loss are present in less than half of patients. The availability of brainstem auditory evoked response testing, fourth-generation CT, and air-CT cisternography have changed the approach to the diagnosis of AT. Neurologists should be cognizant of recent diagnostic advances.

Brain Stem↗
PubMed1983

Dissections of cervical and cerebral arteries.

Dissections have been reported with increasing frequency in recent years. The authors discuss dissection of extracranial carotid, intracranial cerebral, and vertebrobasilar arteries and consider differences in clinical features and in pathophysiologic and therapeutic considerations.

Adolescent↗
PubMed1981

Occurrence and implications of seizures in subarachnoid hemorrhage due to ruptured intracranial aneurysms.

The records of 100 consecutive cases of subarachnoid hemorrhage due to ruptured aneurysm were reviewed to determine the incidence and the prognostic implications of seizures during the acute phase. Seizures occurred in 26% of the patients. Sixty-three per cent of the seizures occurred near the onset of the initial hemorrhage. The occurrence of these early seizures did not correlate with the location of the aneurysm or the prognosis. Most of the remaining seizures occurred immediately after rebleeding, with no greater morbidity or mortality compared to all patients who rebled. Pathogenic mechanisms of seizures associated with subarachnoid hemorrhage are proposed and discussed.

Anticonvulsants↗
PubMed1981

Diagnosis of acoustic neuroma.

The acquisition and application of new techniques in diagnostic screening have changed the approach to patients with suspected acoustic neuroma. In this paper, we review the extensive recent literature on acoustic tumors and present a critical analysis of the various diagnostic investigations. The older tests for cerebrospinal fluid protein, vestibular testing, and arteriography have been supplanted by modern audiometry with acoustic reflex testing, brain stem evoked responses, and computed tomography (CT). The various types of plain radiography are confirmed as an extremely useful screening modality. CT is insufficiently sensitive to serve as a primary screening procedure, but is a valuable confirmatory test. We propose a logical method of screening patients suspected of having an acoustic neuroma that can be applied by any practitioner in any clinical situation.

Adult↗
PubMed1977

The spermatozoan genome and fertility.

The strategy for effective reproduction by eliminating genetically unbalanced gametes during spermatogenesis and transport varies in degree of success within as well as among species, but in no animal has it been reported to be completely effective. In the human subject, for example, it is estimated that one in every 50 ejaculated spermatozoa is genetically abnormal. The causal basis of these anomalies is poorly understood. Meiotic accidents, environmental mutagens, and gamete senescence in utero are all implicated. However, many of these abnormal cells are fertile. This fact plus the weight of the evidence reviewed suggest that fertility differences among males which cannot be ascribed to measurable differences in semen characteristics reflect, in large part, the increased opportunity of nuclear defective gametes in the semen of some males to effect fertilization. The elimination of embryos arising from eggs fertilized by genetically defective spermatozoa through spontaneous abortions, although biologically costly, must be viewed as the final check for the elimination of genetic detritus of the species.

Abortion, Spontaneous↗