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Biomedical subjects

R G Bird

Publications and source records attributed to R G Bird.

At least 37 records · Page 2Linked to original sources
PubMed1975

Fine structural changes at Entamoeba histolytica rabbit kidney cell (RK 13) interface.

When bacteria-free trophozoites of Entamoeba histolytica were added to a monolayer of rabbit kidney cells, cellular injury occurred at the sites of contact. Changes appeared within the cell cytoplasm before there was any generalized cell membrane damage. At some points of contact there was apparent fusion of amoebic and cell cytoplasm. Electron-dense bodies, here interpreted as liposomes, were present in the amoebic cytoplasm and beneath the surface membrane. No surface lysosomes were seen. Various modes of cell damage and enzyme transfer from amoeba to cell are suggested, together with the possibility that cytopathic amoebae are infected with virus particles.

Amebiasis↗
PubMed1975

The nature and incidence of lysogeny in Mycobacterium fortuitum.

Ten of 28 strain of Mycobacterium fortuitum (ranae) were found to be associated with bacteriophage; three were pseudolysogenic, one liberated a phage that lysed a sensitive indicator strain, two liberated morphologically complete phages that did not lyse any of the strains used in this study and four liberated morphologically defective phages. The lysogenic and defectively lysogenic strains showed anomalies in cultural, biochemical and antigenic properties and in susceptibility to superinfecting phages. In view of the high frequency of lysogeny found in M. fortuitum, the role of bacteriophage in the variation of properties, including pathogenicity, of mycobacteria of greater clinical importance merits further consideration.

Bacteriolysis↗
PubMed1974

Intestinal coccidiosis in a patient with alpha-chain disease.

During an ultrastructural study of small-intestinal mucosa from a patient suffering from alpha-chain disease organisms were identified within the epithelial cytoplasm which showed the fine structural features of the coccidian group. Though coccidiosis is well recognized as causing a diarrhoeal and often lethal illness in animals it has been neglected as a cause of disease in man. Thus this finding may be significant and warrants further investigation into its possible role in the pathogenesis of alpha-chain disease.

Adult↗
PubMed1972

A cytoplasmic polyhedrosis virus in midgut cells of Anopheles stephensi and in the sporogonic stages of Plasmodium berghei yoelii.

Although it has been known for some time that nuclear and cytoplasmic polyhedrosis viruses may infect the larval stages of mosquitos capable of transmitting mammalian malaria this paper reports for the first time the presence of a cytoplasmic polyhedrosis virus in adult Anopheles stephensi. The virus was shown to be present in sporogonic stages of Plasmodium berghei yoelii with which the mosquitos were infected. It is possible that other viruses may affect both vector and malaria parasites. Further studies are required of viral infections in mosquitos as a possible method of biological control.

Animals↗