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Biomedical subjects

R G Bennett

Publications and source records attributed to R G Bennett.

At least 91 records · Page 5Linked to original sources
PubMed1988

Periungual hyperpigmentation mimicking Hutchinson's sign associated with minocycline administration.

An assessment of the occurrence rate of periungual hyperpigmentation with subungual melanoma (Hutchinson's sign) and periungual hyperpigmentation with other subungual lesions has not been published, although periungual hyperpigmentation with a pigmented streak or other pigmented lesion of the nail has been considered pathognomonic for subungual melanoma for a century. We report a case of minocycline hyperpigmentation presenting as a longitudinal pigmented streak of the nail associated with periungual hyperpigmentation. These pigmentary changes could be mistaken for Hutchinson's sign.

Adult↗
PubMed1988

Perianal eosinophilic granuloma resembling condyloma latum.

A 2 1/2-year-old boy with eosinophilic granuloma confined to the frontoparietal bones developed a rectal fissure that progressed to a perianal plaque resembling condyloma latum. Biopsy confirmed the presence of many Langerhans cells, and therefore a diagnosis of eosinophilic granuloma involving the skin was made. Although rare, eosinophilic granuloma can be associated with cutaneous lesions, sometimes isolated and mundane in appearance. It should be considered in the differential diagnosis of perianal lesions.

Anal Canal↗
PubMed1987

Sclerosing agents in the treatment of telangiectasia. Comparison of the clinical and histologic effects of intravascular polidocanol, sodium tetradecyl sulfate, and hypertonic saline in the dorsal rabbit ear vein model.

A 0.25-mL quantity of 0.25%, 0.5%, and 1.0% polidocanol (Aethoxysclerol [France]), 0.5% sodium tetradecyl sulfate (Sotradecol injection), and 23.4% hypertonic saline was injected into the dorsal marginal rabbit ear vein; clinical and histologic thrombosis resulted that lasted between four and eight days. The lowest concentration of polidocanol (0.25%) demonstrated immediate thrombosis; however, no clinical or histologic changes occurred eight days after injection. With all other agents, histologic fibrosis of the vessel correlating with clinical disappearance occurred after eight days. However, 0.5% polidocanol and sodium tetradecyl sulfate developed recanalization through the initially sclerosed vessel between eight and 14 days, with clinical reappearance of the 0.5% polidocanol-injected vessel at 30 days, after injection. Cutaneous necrosis was noted clinically and histologically in three of ten vessels injected with 1.0% polidocanol and in two of ten vessels injected with hypertonic saline. Clinical and histologic evidence of necrosis occurred with and without extravasation of the sclerosants.

Animals↗
PubMed1987

Treatment of telangiectasia: a review.

Telangiectasias are thought to occur through the release or activation of vasoactive substances under a multitude of conditions. Patients seek therapy for telangiectasias principally because of the unsightly visual appearance. This paper discusses the etiology, histology, and treatment of telangiectasias, emphasizing microsclerotherapy. Specifically, the indication for sclerotherapy, mechanism of action of the various sclerosing agents, microinjection technic, and the advantages and disadvantages of the most commonly used sclerosants, sodium morrhuate, sodium tetradecyl sulfate (Sotradecol), hypertonic saline, hydroxypolyethoxydodecane (polidocanol; Aethoxysklerol), and, Sclerodex (a mixture of dextrose and sodium chloride) are reviewed.

Dermabrasion↗
PubMed1987

Chemosurgical debridement of osteomyelitic bone by zinc chloride fixative.

Zinc chloride fixative (as described in fixed-tissue Mohs surgery) is useful as a chemical debridement method for osteomyelitic bone. We describe a case of an 86-year-old female with a 67-year history of an osteomyelitic ulcer of the anterior tibia. Previous attempts at surgical extirpation of the bone followed by immediate or delayed repair by orthopedic and plastic surgery services had eventuated in recurrence of the basic osteomyelitic process. Below-the-knee amputation was recommended as the only alternative to treatment. However, we chose to apply zinc chloride fixative which penetrated the full thickness of cortical bone and revealed a wider and deeper extent of the infectious process than previously recognized. Following removal of the fixed bone, a muscle flap repair followed by split-thickness skin grafting was done by plastic surgery. The patient remains ulcer and symptom free 31 months postoperatively. We feel zinc chloride fixative is useful as an adjunct to other surgical means of extirpation of bone as it is tissue sparing and more accurately determines the extent of involved bone when infected.

Aged↗
PubMed1987

Mohs' surgery. New concepts and applications.

During the past decade, Mohs' surgery has been used increasingly, mostly by dermatologists, for the treatment of cutaneous neoplasms, usually basal cell or squamous cell carcinomas. This use has given rise to new developments, both in the technique itself and in basic tumor biology. As more tumors are delineated microscopically in both their histologic and growth patterns, certain concepts are emerging that are important for successful management of skin cancer.

Bowen's Disease↗
PubMed1986

Extravascular effects of sclerosants in rabbit skin: a clinical and histologic examination.

Sclerotherapy refers to the injection of a material for the purpose of obliterating a blood vessel. During this procedure a small quantity of sclerosing solution may be unintentionally injected into the tissues surrounding the vessel, either by missing the vessel or leakage of sclerosant upon withdrawal of the needle. Occasionally, the sclerosant may be intentionally injected into an extravascular site in the hope of reducing telangiectatic mats (best described as multiple, grouped, extremely fine telangiectatic vessels). The various sclerosants in use appear to vary in their potential to cause necrosis of perivascular tissues as a complication. This study examines the clinical and histologic effects of the intradermal injection of 0.1 ml of 0.25, 0.5, and 1.0% Aethoxysklerol (AES); 0.5% Sotradecol (SOT); and 23.4% hypertonic saline (HS) in rabbit skin. All three agents produced some clinical necrosis with intradermal injection. AES in all three concentrations produced the least clinical necrosis, no histologic necrosis, and resolved faster than SOT or HS.

Animals↗
PubMed1985

A shift in the perceived simultaneity of adjacent visual stimuli following adaptation to stroboscopic motion along the same axis.

Adaptation to stroboscopic motion affects the perceived temporal order of two adjacent stimuli presented along the same axis. The extent of shift appears to be independent of the duration of adaptation and under the conditions studied was 3-6 msec in a direction consistent with a cancellation of the motion aftereffect. There was no effect upon the locus of simultaneity when adapting stroboscopic motion was orthogonal to that of the test stimulus.

Adaptation, Ocular↗
PubMed1984

Construct validity of indicator-scales developed from the Comprehensive Assessment and Referral Evaluation interview schedule.

This paper is an assessment of the construct validity of the scales developed from the Comprehensive Assessment and Referral Evaluation (CARE). Data collected from 445 elderly adults residing in New York and 396 in London were used to develop scales to measure medical, psychiatric, and social problems. Diagnostic and global ratings made by psychiatrists and social scientists provided one source of corroborative information; scales developed from information obtained from a random subsample of 162 collateral sources were used as another method of determining validity. Evidence was provided for convergent and divergent validity using multitrait-multimethod matrices to represent the relationships among scales across methods. Convergent validity coefficients ranged from (.40 to .75) for the CARE scales with the diagnostic ratings and from (.30 to .70) for the informant scales. It is argued that most scales are valid by this criterion.

Activities of Daily Living↗
PubMed1984

The meaning of surgical margins.

In an effort to define the pathological term surgical margins, 11 pathologists were interviewed regarding the meaning of the term margins. In addition, 25 plastic surgeons were queried regarding their decisions based on pathology reports of margins. We found nonuniformity of processing specimens and ambiguity in the use of the term close when describing specimen margins. Among the plastic surgeons there was also variability of opinion regarding handling of patients with pathology reports with close or involved margins and a lack of appreciation of the differences and the meanings of various methods of processing tissue.

Biopsy↗
PubMed1984

Delayed extensor tendon rupture: a complication of Mohs surgery.

A 63-year old man is presented who developed a ruptured extensor tendon of the hand 3 days following Mohs surgery (fresh tissue technique) for a recurrent squamous-cell carcinoma. Retrospective examination of this case led us to conclude that several different factors (partial tendon laceration, infection, and underlying medical problems) jointly contributed to this complication. These factors are discussed, along with recommendations for management of such cases.

Carcinoma, Squamous Cell↗
PubMed1984

Failure of curettage and electrodesiccation for removal of basal cell carcinoma.

Sixty-nine primary basal cell carcinomas were treated by curettage and electrodesiccation three times, and subsequently, excised tissue was analyzed for microscopic persistence of tumor. We found persistent tumor in 33.3% of cases overall. Of 45 lesions on the head, residual tumor was detected microscopically in 46.6%, whereas of 24 lesions on the trunk and extremities, residual tumor was found in only 8.3%. This difference was statistically significant, even though the average precurettage and postcurettage sizes of the lesions in these two groups were comparable. Therefore, we conclude that basal cell carcinomas are more resistant to ablation with curettage and electrodesiccation on the head than on the trunk or extremities.

Adult↗