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Biomedical subjects

R Frydman

Publications and source records attributed to R Frydman.

At least 379 records · Page 21Linked to original sources
PubMed1982

Premature ovulation after ovarian ultrasonography.

Whereas follicle rupture never occurred before the 37th hour after an ovulatory stimulus (either the onset of the LH surge or hCG administration) in control patients, ovulation was observed at 26 to 36 h in women submitted to ultrasonography during the late follicular phase. Premature ovulation was observed in 5 out of 23 and 8 out of 19 cycles when ultrasonography occurred during the 3 days preceding or in the 36 h following ovulatory stimulus. This as yet unexplained observation leads us to reconsider the advisability of ovarian scan during the late follicular phase of the menstrual cycle.

Adult↗
PubMed1982

Seasonal influence of diurnal rhythms in the onset of the plasma luteinizing hormone surge in women.

The time of the LH surge onset in plasma was detected in 75 human cycles. The preovulatory LH surge began between midnight and 0730 h in two thirds of the patients. According to the season of study, the LH surge began between 1030 and 2215 h in 52.4% of the spring cycles compared with 12.9% of the cycles studied during other seasons (P less than 0.001). The highest frequency of the LH surge occurrence over a 3-h time interval was 1500 +/- 1.5 h during the spring cycles (28.6%) and 0300 +/- 1.5 h (42.5%) during the other seasons. It was estimated that ovulation occurred primarily in the morning during the spring and primarily in the evening during autumn and winter.

Adult↗
PubMed1982

The preovulatory follicular fluid in the human: influence of hormonal pretreatment (clomiphene-hCG) on some biochemical and biophysical variables.

Some biochemical and biophysical variables of human follicular fluid have been studied both in normal women after the LH peak (preovulatory follicles) and in women treated with clomiphene and hCG (clomiphene treated follicles). The results showed that lactate and glucose levels are different from those found in serum but are not influenced by the clomiphene treatments. Osmolarity and enzymatic contents are neither different from those of serum nor modified by the hormonal treatments. The transfer of water across the follicle wall was found to be closely regulated because only slight variations were observed in the wide range of volumes collected in the samples examined.

Adult↗
PubMed1982

[Prediction of ovulation].

Predicting ovulation is the basis on which the fertile period is determined. When we carried out observations on 60 spontaneous cycles it was possible to detect with precision the discharge of LH which would produce ovulation by taking series of plasma levels of LH. The start is defined as the time when the level of LH becomes 180% greater than the mean level observed in the previous 24 hours. Ovulation occurs between 37 and 39 hours after this threshold has been crossed. The discharge of LH is the most constant criterion and the most precise one, and it does make it possible to work out the chronology of the events that precede ovulation. Ultrasound and estimation of levels of oestradiol in the plasma or in the urine do allow one to appreciate how the follicle is maturing.

Body Temperature↗
PubMed1981

[Spontaneous abortion after intra-uterine transfer of an ovum fecundated in vitro (author's transl)].

Spontaneous expulsion of a human ovum fecundated in vitro and transferred into the uterus occurred after 10 1/2 weeks of amenorrhoea. The oocyte had been collected after stimulation by human menopausal and chorionic gonadotrophins (hMG and hCG). The techniques of pre-ovulatory oocyte collection, fecundation, in vitro culture and of reimplantation of the embryo are briefly described.

Abortion, Spontaneous↗
PubMed1981

Interpretation of plasma luteinizing hormone assay for the collection of mature oocytes from women: definition of a luteinizing hormone surge-initiating rise.

Analysis of plasma luteinizing hormone (LH) assays (4 assays per day) permits the discernment of the onset of the physiologic effects of ovulatory release. This threshold value of LH plasma concentration (LH surge-initiating rise, LH SIR) is determined for each cycle in terms of the average baseline level of the previous day. The chronology of follicle and oocyte maturation after LH SIR is similar to that which follows chorionic gonadotropin (hCG) administration: none of the 20 patients, compared with 2 out of 10, had ovulated when laparoscopy was performed 30 to 35 hours and 36 to 38 hours after LH SIR time, respectively; 1 out of 3, 9 out of 14, and 5 out of 5 patients had an in vitro fertilized egg when oocytes were collected 30 to 32, 33 to 35, and 36 to 38 hours after LH SIR time, respectively. Thus the oocyte can be collected 34 to 35 hours after the LH SIR; at this point ovulation has not occurred and the oocyte is capable of being fertilized.

Adult↗
PubMed1981

Inhibin-like activity and steroid content in human follicular fluid during the periovulatory period.

Inhibin-like activity as well as estradiol-17 beta and progesterone content were assayed in human follicular fluid obtained at different stages of the periovulatory period. Between the start of the midcycle estrogen surge in plasma and the subsequent gonadotrophin peak, follicular fluid was found to contain similar levels of estradiol-17 beta and progesterone (8.2 pmol/microliter) and to induce a marked (44%) inhibition of gonadotrophin-releasing hormone-stimulated release of FSH. The midcycle gonadotrophin peak was characterized by a drop in estradiol-17 beta levels and a tripling in progesterone levels, whereas inhibin-like activity fell to almost half the previous value.

Adult↗
PubMed1981

[Recovery of preovulatory human oocytes (author's transl)].

Rapid radio-immune assaying of LH was carried out four times daily on 52 women in the preovulatory phase of the cycle. This method enables the precise detection of the LH surge and recovery of the mature oocyte by laparoscopic aspiration of the follicular content, just before ovulation, which is between 28 and 36 hours after the start of the LH surge. The oocytes was recovered in 27 out of 41 patients with a normal cycle (66%). The rate of recovery per follicle aspirated is comparable in a natural cycle to that after treatment with Clomid (80 to 84%).

Adult↗
PubMed1980

[Sexually transmissible diseases in adolescence (author's transl)].

Sexually transmissible diseases affect adolescents as well as the rest of the French population. It is difficult to estimate their frequency from official statistics since not all cases are reported. However, the recrudescence of these diseases is certain, with adolescents representing 10 to 50 0/00 of all cases. These diseases threaten the obstetrical and gynecologic future of adolescents and cost society a great deal of money. In the combat against them, prevention and public education are as important as early screening.

Adolescent↗
PubMed1980

[Human in vitro fertilisation. Preliminary results (author's transl)].

We here report the results of our first attempts at fertilising the human oocyte in vitro. No external hormonal stimulation was used to induce follicular growth or maturation of the oocyte. Nine oocytes were obtained laparoscopically in ten women in the pre-ovulation hours. They were incubated in a synthetic culture medium in the presence of freshly ejaculated spermatozoa. Five oocytes were fertilised normally, of which three were cultured just up to the stage of 4-6 blastomeres. The three failures of fertilisation can be put down to poor quality of the gametes. The discussion is carried on about the quality of the oocyte and of the embryo and justifies further studies to deepen our knowledge before embarking on embryo transplant.

Blastomeres↗
PubMed1980

[Lysozyme content of amniotic fluid (A.F.) (author's transl)].

Lysozyme content of 47 A.F. collected at different stages of pregnancy has been measured. At the same time creatinine concentrations of 33 of those A.F. have been measured. Lysozyme content increases with the progress of the pregnancy. A similar increase is apparent when lysozyme concentration is correlated with A.F. creatinine.

Amniotic Fluid↗
PubMed1980

[Adolescent pregnancy (author's transl)].

The number of pregnancies in adolescents is increasing in most countries and represents a public health problem. Teenage pregnancies are in the high-risk group. However, early recognition and correct management make them as safe as those of older women except for two complications which seem to be peculiar to them: toxemia of pregnancy and premature delivery. In addition, a higher frequency of congenital defects of unknown etiology was observed in our study.

Adolescent↗
PubMed1980

[Adolescent girls and contraception (author's transl)].

The fact that 20% of the abortion requests at Antoine-Béclère Maternity Hospital in 1978 came from women under 20 years of age makes it clear that teenagers are insufficiently informed and familiar with contraception and makes it obvious that a change is necessary. The different types of contraception and the conditions of choice and application are briefly described.

Adolescent↗
PubMed1979

Delivery of twin pregnancy.

Preliminary observations fail to indicate a higher risk to the twin babies as a result of labor induction or Cesarian section, so that a systematic clinical trial will now be possible.

Birth Injuries↗