Can we identify abusive bites on children?
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Adolescent↗
Biomedical subjects
R Frost
Publications and source records attributed to R Frost.
Transcriptional analysis of human peripheral blood mononuclear cells after influenza immunization.
Influenza A virus is a major cause of morbidity and mortality worldwide. There is a large knowledge base on the immune response to influenza. However, few studies have focused on global gene expression in immune cells after antigenic challenge. A better understanding of the host immune response is required for the development of more efficient means of prevention and treatment of influenza. In this study, global gene expression in peripheral blood mononuclear cells (PBMCs) after influenza immunization was analyzed. The differential gene expression in antigen-stimulated and non-stimulated PBMCs was determined by cDNA microarrays. To determine whether a specific gene profile was present during a proliferative memory cell response to influenza antigens, gene expression in response to PHA was compared with antigen-stimulated PBMCs. PHA induced the upregulation of 201 genes while influenza virus antigen upregulated more than triple that is 630 genes out of 1700 genes analyzed. Both influenza antigen and PHA commonly upregulated 138 genes. Interferon (IFN)-related genes were induced by influenza but not by PHA. The interferon-gamma induced protein precursor 10 (IP-10) was upregulated 27-fold while the interferon-induced 54 kDa protein exhibited a 13-fold increase. The following gene families were also selectively upregulated by influenza antigens: complement ligands and receptors, T cell activation genes, growth factors, genes related to antigen processing and inflammatory responses. With PHA, the genes TNF-R, CTSG, CD3 delta, C8B, CRF1 and CCR2 had higher expression compared with the viral antigen stimulation. Neutrophil defensins alpha-1 and two C-C chemokines, proteins MIP-1-beta and MIP-4, were among the genes upregulated by both PHA and influenza antigens. The results suggest that interferon-induced genes are one of the main transcriptional targets during the immune response to influenza virus.
Antigens, Viral↗
Serum insulin concentrations in horses with equine Cushing's syndrome: response to a cortisol inhibitor and prognostic value.
REASONS FOR PERFORMING STUDY: Serum insulin concentration and its use as a prognostic indicator in horses with equine Cushing's syndrome (ECS) have been poorly documented. OBJECTIVES: To examine daily insulin variations in horses with ECS and the effect of treatment using trilostane, a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase. Further, we aimed to examine the relationship between baseline serum insulin concentration and survival in horses with ECS. METHODS: Basal serum insulin concentrations were measured in 20 confirmed ECS cases by taking blood at regular 4 h intervals for 24 h (1200, 1600, 2000, 2400, 0400 and 0800 h) before treatment (Day 0) and 10 days, and 30 days and 1-2 years after the onset of trilostane therapy. The temporal pattern of insulin was analysed using a linear mixed model approach, and the prognostic value of measurements on Day 0 assessed using receiver-operating characteristic analysis. RESULTS: Horses with ECS showed a diurnal pattern of serum insulin concentration, highest value at 1200 h, and this pattern was not altered by treatment with trilostane. Furthermore, despite a mild increase of serum insulin concentrations after 10 days of trilostane therapy, insulin concentration was unaffected in the long-term. Low serum insulin concentrations at the beginning of the trial were significantly associated with improved survival to 1-2 years. The 1200 h sampling before treatment had the highest prognostic value for prediction of survival with a sensitivity and specificity of at least 90% for serum insulin at < 62 and > 188 microu/ml to predict survival and nonsurvival, respectively. CONCLUSIONS AND POTENTIAL RELEVANCE: Insulin is a useful prognostic indicator for ECS, but potentially large variations can occur throughout a 24 h period, indicating a single sample may not be representative. Serum insulin concentration did not increase over 1-2 years in horses receiving trilostane therapy.
3-Hydroxysteroid Dehydrogenases↗
Linguistic theory and psychological reality: a reply to Boudelaa & Marslen-Wilson.
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Cognition↗
Effect of diabetes mellitus on rat placenta cellularity.
Transcellular placental maternofetal flux of calcium and magnesium is reduced in diabetic pregnancy in the rat which might be due to changes in placental cellularity. In order to investigate this wet and dry weight, DNA and protein content were measured in placentas from untreated diabetic (D(O)), insulin-treated diabetic (D(I)) and control rats (C) on day 21 of gestation (term=23 days). Wet and dry weights (mg; mean+/-S.E.M.) were 418+/-13, 474+/-19, 416+/-14 and 66+/-3, 75+/-3, 67+/-3 in C, D(O) and D(I) groups, respectively. Total DNA and protein content (mg) was 1.8+/-0.2, 1.7+/-0.1, 1.5+/-0.1 and 50.4+/-2.4, 54.9+/-2.6, 51.9+/-3.3 in C, D(O) and D(I) groups, respectively. The data suggest that placental cellularity is unaffected by maternal diabetes mellitus in the rat and is unlikely to directly affect maternofetal flux of calcium and magnesium.
Animals↗
Relation of plasma leptin concentrations to sex, body fat, dietary intake, and peak oxygen uptake in young adult women and men.
The purpose of this study was to examine the relation of leptin to metabolic and dietary factors in college-age adults. Young adult women and men (n = 32) were recruited and underwent testing for measurement of body mass index, body composition, peak oxygen consumption (VO2peak), dietary intake, and plasma levels of leptin and insulin. Ln leptin was significantly greater for women than for men (2.1 versus 1.2 ng/mL, respectively). This difference remained significant even after adjusting ln leptin for fat mass and fat-free mass as covariates in separate analyses. VO2peak was higher for men than for women and this remained significant after adjustment for differences in fat-free mass and total body mass. Significant correlations were found between ln leptin and indicators of fat mass in women and men, with higher correlations for similar variables observed in men (r = 0.548, 0.674, and 0.732 for body mass index, percentage of body fat, and fat mass [kg] for women, respectively, and r = 0.740, 0.888, 0.858 for body mass index, percentage of body fat, and fat mass [kg] for men, respectively). Ln leptin showed a significant inverse relationship with VO2peak (r = -0.751) in men only. After adjusting ln leptin for body fat mass using partial correlations, ln leptin was not significantly associated with any of the measured variables. Alternatively, after normalization of ln leptin using fat mass as the divisor, a less adequate statistical analysis method, men showed statistical significant correlations between ln leptin and dietary intake and VO2peak. Although plasma leptin values were higher in women, stronger associations were evident for men than for women between leptin and metabolic and dietary factors.
Adipose Tissue↗
Two routes to grammatical gender: evidence from Hebrew.
Access to grammatical gender in Hebrew was examined using gender decisions and grammaticality judgments. In gender decisions, and in rejecting agreement violations, the role of gender-marking regularity was robust; irregular feminine nouns were classified more slowly and produced more errors than did regular masculine nouns. These same exception nouns, however, produced radically different results when they appeared as part of a grammatical phrase. In this context, irregular nouns were processed as quickly and accurately as were regular nouns. These findings are interpreted within a model containing two routes to grammatical gender: one that involves an abstract gender node, and another that is form-based and is assumed to play a greater role in recovery from agreement errors. We also argue that there are cross-linguistic variations in the availability and speed of the form-based route to gender. Finally, we caution that under some circumstances grammatical gender may also be retrieved through a variety of heuristics that do not necessarily reflect the normal mechanisms of access to gender.
Humans↗
Orthographic and phonological computation in visual word recognition: evidence from backward masking in Hebrew.
We employed the backward masking paradigm to map the early computation involved in the perception of printed words in Hebrew. By independently manipulating orthographic and phonological overlap between targets and masks, we examined whether orthographic and phonological structure imposes late or early constraints on lexical access. The results demonstrated that the probability of reinstating a masked target depended on both the orthographic and the phonological overlap between the target and the mask. However, whereas phonemic structure seems to constrain lexical access only at short exposure durations, orthographic overlap also exerts its influence at longer durations.
Adult↗
Decomposing morphologically complex words in a nonlinear morphology.
Most Hebrew words are composed of 2 intertwined morphemes: a triconsonantal root and a phonological word pattern. Previous research with conjugated verb forms has shown consistent priming from the verbal patterns, suggesting that verbal forms are automatically parsed by native speakers into their morphemic constituents. The authors investigated the decomposition process, focusing on the structural properties of verbal forms that are perceived and extracted during word recognition. The manipulations consisted of using verbal forms derived from "weak" roots that have one consonant missing in some of the forms. The results demonstrated that if 1 consonant is missing, the parsing system collapses, and there is no evidence for morphological priming. In contrast, when a random consonant is inserted into the weak form, the verbal-pattern priming re-emerges. This outcome suggests that the constraint imposed on the decomposition process is primarily structural and abstract. Moreover, the all-or-none pattern of results is characteristic of rule-based behavior and not of simple correlational systems.
Adult↗
A prospective randomised multicentre trial comparing 10 Fr Teflon Tannenbaum stents with 10 Fr polyethylene Cotton-Leung stents in patients with malignant common duct strictures.
BACKGROUND: Stent blockage is a multifactorial process in which stent design and materials, bacteria, proteins, and bile viscosity play a role. AIMS: To compare the patency of the 10 Fr Teflon Tannenbaum (TT) stent to that of the 10 Fr Cotton-Leung (CL) polyethylene stent with sideholes, in patients with malignant obstructive jaundice. METHODS: Patients were recruited to this prospective multicentre randomised study if they had a newly diagnosed malignant bile duct stricture below the hilum of the liver suitable for stenting with a 10 Fr stent. Data were collected and monitored by a professional monitoring company. Primary patency was the interval between stent placement and first exchange or death without recurrent jaundice. RESULTS: 134 consecutive patients were recruited between November 1994 and June 1997; 65 were randomised to the TT stent and 69 to the CL stent. Median patency and 95% confidence intervals were 181 (59, 303) days for the TT stent and 133 (92, 174) days for the CL stent, with no significant difference between the two stents (p=0.49). Median survival and 95% confidence intervals were 115 (71, 159) days for the TT stent and 151 (112, 190) days for the CL stent, with no significant difference between the two stents (p=0.765). CONCLUSION: Neither Teflon as a stent material nor the Tannenbaum design prolong the patency of plastic stents.
Adult↗
Morphological priming: dissociation of phonological, semantic, and morphological factors.
Previous experiments based on a masked-priming paradigm revealed robust morphological priming effects induced by two derivational morphemes in Hebrew: the root and the verbal pattern. However, considering the special characteristics of the masked-priming paradigm, the possible contributions of phonological and/or semantic factors to these morphological effects could not be firmly assessed. In the present study, the role of these factors in morphological priming was examined, using cross-modal presentation. Experiment 1 revealed that priming between morphologically related words in Hebrew is determined by higher level linguistic characteristics and cannot be reduced to phonological overlap. Experiment 2 confirmed that morphological priming occurs in Hebrew even when primes and targets are not semantically related but, nevertheless, increases with semantic similarity. The results support the claim that morphological priming cannot be accounted for by considering semantic and phonological factors alone, and they exemplify the potential of using both masked and cross-modal priming to examine morphological processing.
Adult↗
Biochemical separations by continuous-bed chromatography.
Innovations in column-packing media for biomolecule purification have progressed from large spherical, porous polysaccharide beads to advanced polymeric supports. Continuous-bed technology is a radical new technology for chromatography based on the polymerization of advanced monomers and ionomers directly in the chromatographic column. The polymer chains form aggregates which coalesce into a dense, homogeneous network of interconnected nodules consisting of microparticles with an average diameter of 3000 A. The voids or channels between the nodules are large enough to permit a high hydrodynamic flow. Due to the high cross-linking of the polymer matrix, the surface of each nodule is nonporous yet the polymeric microparticles provide a very large surface area for high binding capacity. This paper will demonstrate the properties and advantages of using a continuous bed support for high resolution biomolecule separations at high flow-rates without sacrificing capacity.
Animals↗
Verbs and nouns are organized and accessed differently in the mental lexicon: evidence from Hebrew.
A masked priming paradigm was used to examine the role of the root and verbal-pattern morphemes in lexical access within the verbal system of Hebrew. Previous research within the nominal system had showed facilitatory effects from masked primes that shared the same root as the target word, but not when the primes shared the word pattern (R. Frost, K. I. Forster, & A. Deutsch, 1997). In contrast to these findings, facilitatory effects were obtained for both roots and word patterns in the verbal system. In addition, verbal pattern facilitation was obtained even when the primes were pseudoverbs consisting of illegal combinations of roots and verbal patterns. Significant priming was also found when the primes and the targets contained the same root. The results are discussed with reference to the factors that may determine the lexical status of morphological units in lexical organization. A model of morphological processing of Hebrew words is proposed.
Humans↗
Toward a strong phonological theory of visual word recognition: true issues and false trails.
A strong phonological theory of reading is proposed and discussed. The first claim of this article is that current debates on word recognition are often based on different axioms regarding the cognitive structures of the mental lexicon rather than conflicting empirical evidence. These axioms lead to different interpretations of the same data. It is argued that once the implicit axioms of competing theories in visual word recognition are explicated, a strong phonological model presents a viable and coherent approach. The assumptions underlying a strong phonological theory of reading are outlined, and 4 theoretical questions are examined: Is phonological recoding a mandatory phase of print processing? Is phonology necessary for lexical access? Is phonology necessary for accessing meaning? How can phonology be derived from orthographic structure? These issues are integrated into a general theory that is constrained by all of the findings.
Cross-Cultural Comparison↗
Fourier transform infrared spectrometry: a versatile technique for real world samples.
The versatility of FTIR spectrometry was explored by considering a variety of samples drawn from industrial applications, materials science and biomedical research. These samples included polymeric insulators, bauxite ore, clay, human hair and human skin. A range of sampling techniques suitable for these samples is discussed, in particular FTIR microscopy, FTIR emission spectroscopy, attenuated total reflectance and photoacoustic FTIR spectrometry. The power of modern data processing techniques, particularly multivariate analysis, to extract useful information from spectral data is also illustrated.
Hair↗
What can we learn from the morphology of Hebrew? A masked-priming investigation of morphological representation.
All Hebrew words are composed of 2 interwoven morphemes: a triconsonantal root and a phonological word pattern. the lexical representations of these morphemic units were examined using masked priming. When primes and targets shared an identical word pattern, neither lexical decision nor naming of targets was facilitated. In contrast root primes facilitated both lexical decisions and naming of target words that were derived from these roots. This priming effect proved to be independent of meaning similarity because no priming effects were found when primes and targets were semantically but not morphologically related. These results suggest that Hebrew roots are lexical units whereas word patterns are not. A working model of lexical organization in Hebrew is offered on the basis of these results.
Decision Making↗
Translation priming with different scripts: masked priming with cognates and noncognates in Hebrew-English bilinguals.
Hebrew-English cognates (translations similar in meaning and form) and noncognates (translations similar in meaning only) were examined in masked translation priming. Enhanced priming for cognates was found with L1 (dominant language) primes, but unlike previous results, it was not found with L2 (nondominant language) primes. Priming was also obtained for noncognates, whereas previous studies showed unstable effects for such stimuli. The authors interpret the results in a dual-lexicon model by suggesting that (a) both orthographic and phonological overlap are needed to establish shared lexical entries for cognates (and hence also symmetric cognate priming), and (b) script differences facilitate rapid access by providing a cue to the lexical processor that directs access to the proper lexicon, thus producing stable noncognate priming. The asymmetrical cognate effect obtained with different scripts may be attributed to an overreliance on phonology in L2 reading.
Adult↗
The effects of planned duration of residential drug abuse treatment on recovery and HIV risk behavior.
OBJECTIVE: This study assessed the effects of planned duration of residential drug abuse treatment on recovery from drug use and on human immunodeficiency virus (HIV) risk behaviors. METHODS: Two concurrent randomized controlled trials of programs differing in planned duration were conducted: 6-month vs 12-month versions of a traditional therapeutic community program, and 3-month vs 6-month versions of a modified therapeutic community incorporating a relapse prevention and health education program. Outcomes, measured at least 16.5 months after admission, included time from admission to first drug use; severity of drug, alcohol, legal, and employment problems; and risky drug injection and sexual behaviors. RESULTS: Among 539 clients (86% of those enrolled), there were no significant effects of planned duration of treatment upon Addiction Severity Index scores or HIV risk behavior. In the relapse prevention program, clients randomized to the 6-month program had a longer time to first drug use than those in the 3-month program (hazard ratio = 0.74; 95% confidence interval = 0.58, 0.93). Employment problems at follow-up were significantly less severe among clients treated in the therapeutic community than among those in the relapse prevention program. CONCLUSIONS: No overall benefit of extending treatment beyond 6 months was found.
Adult↗