Search PubMed⌕ Search

Biomedical subjects

R Frey

Publications and source records attributed to R Frey.

At least 127 records · Page 7Linked to original sources
PubMed1988

[Idiopathic atrial fibrillation: the course in paroxysmal and chronic forms].

Among 85 patients (including 16 women) with lone or idiopathic atrial fibrillation, 38 had a purely paroxysmal form while 47 showed chronic fibrillation, usually after a paroxysmal onset. Serious complications (congestive heart failure, syncope and embolic events) occurred in only two paroxysmal cases but in 11 chronic cases (rate of complications per year was 1.3% and 3.8% respectively). Thromboembolism was only observed after chronic fibrillation lasting longer than one year. Paroxysmal patients may be characterized by typical anamnestic features, namely short episodes of arrhythmia (usually less than 24 hours) and constant causative circumstances (mainly vagal stimulation). In these cases antiarrhythmic drugs are not usually recommended.

Adult↗
PubMed1986

Response of isolated guinea pig myocardium to insulin therapy during normothermia and graded hypothermia.

The discovery of insulin in 1922 aroused immediate clinical interest in its use in heart disease. In severe heart failure, insulin release is suppressed by the combined effect of poor pancreatic perfusion and by increased sympathetic activity. In these circumstances, myocardial metabolism of glucose may break down through the deficiency of insulin. Because of this, glucose, insulin and potassium solution (GIK solution) has been used in cardiopulmonary resuscitation. However, its mechanism is not yet fully known. This study was designed to determine the effect of insulin on cardiac muscle at various temperatures. The mechanical response of papillary muscle isolated from guinea pig ventricle was observed under various thermal conditions (23-37 degrees C). Twitch tension was increased by the administration of 0.2 I.U./ml insulin under each thermal condition. In all circumstances, the increase in contractile force was noted about 2 min after the administration of insulin. The effect of insulin on 20 preparations demonstrated the mean maximum contractile force was 226% ( +/- 34 S.D., n = 5) in 37 degrees C, 194% ( +/- 36 S.D., n = 5) in 30 degrees C, 190% ( +/- 30 S.D., n = 5) in 27 degrees C and 200% ( +/- 36 S.D., n = 5) in in 23 degrees C. The differences between different temperatures was not significant. The effect of insulin during depression Na-K pump by high concentration of ouabain (g-strophanthin, 10(-5) M) was also observed. Insulin (0.2 I.U./ml) was administered when the papillary muscle showed no response to electrical stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1985

[Hormone and metabolism behavior in distress without physical stress].

The psychological effects on cortisol, human growth hormone (HGH), free fatty acids and lactate were investigated in 10 healthy students using a one hour television game. To insure that only the psychological aspects of the game were being measured, hematocrit, creatininkinase, CK-MB and myoglobin were used as controls. The game began 60 minutes after venapuncture of a lower arm vein with an indwelling catheter. Blood samples were taken 30 and 60 minutes after venapuncture, at intervals of 20 minutes during the game and 30, 60 and 120 minutes after the end of the game. After an initial rise, plasma cortisol levels sank steadily and significantly (alpha = 1%). The HGH level initially fell, but as the game progressed, rose and remained at a high level for a considerable period after the game had ended. These variations however were not statistically significant. The three free fatty acids under investigations, myristinic acid (C14), palmitic acid (C16), and stearic acid (C18), all showed similar levels over the course of the experiment. During the first 20 minutes of the play, free fatty acid levels rose, with stearic acid levels rising the most (52%). The free fatty acid levels then sank as the game progressed, with the palmitinic acid level showing a significant decline (alpha = 1%). The other parameters remained relatively constant during the experiment, with the exception of the CK-MB level, which showed severe, hard-to-interpret variations.

Adult↗
PubMed1984

[Computer-assisted monitoring in intensive care].

Computerized intensive care in children and infants is possible. But it requires: 1. a modification and extension of the commercially available soft-ware, 2. a sampling rate of 2 values/min or more [7,8] and 3. the noninvasive measurement of the parameters, especially for long-time recordings. - The graphical presentation of the parameters for a longer time shows typical patterns, which lead to an earlier recognition of critical situations. Thus earlier therapy becomes possible. Other characteristic patterns no doubt will be discovered by further research.

Blood Gas Analysis↗
PubMed1982

[The value of serum ferritin, serum iron and iron-binding capacity in the differential diagnosis of microcytic hypochromic anemia].

Ferritin, iron, total iron binding capacity and transferrin saturation were measured in the serum of 247 patients with microcytic hypochromic anemia. Differentiation into various categories of microcytic hypochromic anemia was based on clinical criteria and on the response to iron treatment. This produced 147 patients with iron deficiency anemia, 35 patients with anemia secondary to infection, 27 patients with anemia due to tumor and 38 patients with thalassemia. Analysis of the iron parameters revealed the reliability of both serum ferritin and transferrin saturation in distinguishing between the various forms of anemia. However, measurement of serum ferritin is slightly more reliable and much less expensive than determination of transferrin saturation.

Anemia, Hypochromic↗
PubMed1982

[Chronic alcohol consumption and use of anesthetics - retrospective study of laryngectomies].

It was the purpose of this clinical retrospective study, which was conducted under homogeneous conditions, to find out whether there is a connection between chronic alcoholism and the consumption of narcotics. We examined a group of tumour patients who had to undergo partial laryngectomy in anaesthesia with neuroleptics. We examined 161 reports with regard to their statistical valuation. 21 patients were selected from group A in whom anaesthesia with neuroleptics had been induced with Thiopental, Droperidol and Fentanyl, and 48 patients from group B in whom anaesthesia with neuroleptics was induced with Flunitrazepam and Fentanyl. The patients of both groups were divided into three groups according to their previous alcohol history: Daily consumption of alcohol group I less than 20 ml, group II 20-100 ml, group III greater than 100 ml. Group A turned out to be too small for statistical valuation. But the mean values of Fentanyl consumption indicated dependence on the quantity of alcohol consumed. Group B was analysed statistically. In spite of the fact that there was a lack of statistical significance, the mean values for the consumption of Fentanyl (in group II higher by 7.8% and in group III higher by 16.9% than in group I) did show a dependence on alcohol abuse, the more so since signs of insufficient anaesthesia were reported by such patients only in whom severe abuse of alcohol had been established.

Alcohol Drinking↗
PubMed1982

[Computerized cardiac rhythm and heart analysis in children with mitral valve prolapse (author's transl)].

Twenty-nine children with echocardiographically-proven mitral valve prolapse (MVP) were studied by means of exercise-ECG testing, and continuous ECG monitoring. ECG's were stored on tape and compared with those of 20 healthy children. The frequency of supra- and ventricular premature beats (VPB) and the response of heart rate and RR intervals over the length of time ("tachogram") were graphed and analyzed by various algorithms. Of the children with MVP, one required treatment for his arrhythmia. A total of 16 children with MVP ( = 55%) had various rhythm disturbances. VPB's were observed in one child in the routine ECG, in four children during exercise testing, and in nine only during continuous ECG monitoring, whereas only 9% of the healthy children were found to display VPB's. Differences could also be seen in the tachogram readings: 22 ( = 76%) MVP children were characterized by a wide variation of RR intervals, suggesting a pronounced sympathetic reactivity, twelve ( = 60%) healthy and six ( = 23%) MVP children showed a narrow, oscillating tachogram trace. Although the syndrome is already present in childhood, it must be seen as progredient, manifesting itself in the frequency and gravity of arrhythmias.

Adolescent↗