Condylomatous lesions, although readily diagnosed on the vulva, are often missed in the vagina and on the cervix by clinical examination alone. The lesions are, however, quite common and may be misdiagnosed as mild dysplasia by cytology, colposcopy and even tissue examination. Condylomatous lesions are presently diagnosed on cytologic evidence in nearly two per cent of asymptomatic patients screened in our program and followed-up by colposcopy and tissue examination, when indicated. The cytologic presentation of these lesions is quite characteristic. The main features are seen in squamous cells: enlargement, bi- or multinucleation, hyperchromasia, peri-nuclear clearing, amphophilia and dyskeratotic changes. Our present experience indicates that a large number of lesions previously classed as mild dysplasias actually represent various stages of condylomatous lesions. When these stages of viral changes are removed from the group of dysplasias, the remaining cases become of much greater significance as the early stages of evolution of carcinomata of the cervix.

Adult↗

PubMedDate not supplied

Sensitivity to "atypical" mycobacteria in high school children in two community health departments.

To evaluate the prevalence of atypical mycobacteria infections in our population, a study was done among students of secondary fifth grade (15-19 years of age) in the community health departments of Maisonneuve-Rosemont in Montreal and of Sherbrooke. The tuberculin used was the RT-23 2 T.U. with Tween 80 and the sensitins prepared by the Statens Serum Institute of Copenhagen from Mycobacterium intracellulare (Battey) and from Mycobacterium kansasii. Each student had a tuberculin test on one arm and a sensitin test on the other. The sensitins were randomly allocated. Depending on how the prevalence is calculated, the Mycobacterium intracellulare infection varies from 3 to 20% in Montreal and from 0 to 9.6% in Sherbrooke. The Mycobacterium kansasii infection is much less important in both regions. All reactions to those atypical mycobacteria are in the range of tuberculin reactions of 0 to 9 mm. In our population which is weakly infected with atypical mycobacteria, the level of positivity of tuberculin reactions to 2 T.U. RT-23 or 5 T.U. P.P.D. would give a more realistic evaluation of M. tuberculosis infection if it was fixed at 5 mm than at 10 mm as it is now.

Adolescent↗

PubMedDate not supplied