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Biomedical subjects

R Fischer

Publications and source records attributed to R Fischer.

At least 649 records · Page 36Linked to original sources
PubMed1981

[Incidence of female gonorrhoea in relationship with inflammatory gynaecological diseases - verification from cultures (author's transl)].

Gonorrhoea was detected in 7.3 per cent of 423 patients with gynaecological inflammations. Positive findings were recorded from 8.5 per cent of 248 patients with adnexitis and 6.9 per cent of 130 patients with fluor. However, gonorrhoea incidence among 31 patients with pointed condyloma was as low as 3.2 per cent. These findings were found to differ drastically from the data so far obtained from the common approach of microscopic diagnosis by which hardly any positive detection of gonococci had been recordable from gynaecological out-patients over the years. The present considerable rise in positive findings has resulted only from the use of a modified transport medium, according to Stuart, which proved to be highly applicable to gynaecological practice. With the authors' patients, the new approach showed the presence of gonorrhoea in one of 14 patients with inflammatory gynaecological processes. Against the background of the present epidemiological situation, verification of gonococci from cultures should be made an integral component of gynaecological routine checks.

Adolescent↗
PubMed1980

[Asymptomatic haematuria (author's transl)].

Mesangioproliferative glomerulonephritis of varying severity was found by renal biopsy in 86.2% among 130 patients with asymptomatic haematuria. 3.2% had benign nephrosclerosis, 3.2% had benign nephrosclerosis, 1.6% had interstitial nephritis and one patient showed a previously undiagnosed perimembranous glomerulonephritis. Normal renal parenchyma was observed in only 6.9% of cases. Iummunohistological findings were positive in 25.7% of investigated cases. The majority were IgA deposits combined with IgG and C3 complement. The intensity of haematuria is not correlated with the type and severity of histological changes. "Physiological" haematuria (erythrocytes less than 7/ml) which is usually considered normal must be re-evaluated as a consequence of these histological findings. After exclusion of urological or extrarenal disease only histological investigation of the kidneys will bring the final diagnosis. Repeated radiographical or urological investigations can thus be avoided. The risks of percutaneous renal biopsy under fluoroscopic or sonographic control are decidedly less than the information gained from histological evaluation. The different histological findings indicate that isolated haematuria should be considered only as a symptom and not as a uniform disease indicating focal nephritis.

Adolescent↗
PubMed1980

[Relapse prognosis for patients with adenocarcinoma of the gastrointestinal tract on the basis of carcinoembryonic antigen (CEA) and its circulating immune complexes (author's transl)].

CEA immune complexes and free CEA were routinely determined in sera of 350 patients with adenocarcinoma of the gastrointestinal tract preoperatively and during a 2-year surveillance period. We could detect circulating CEA immune complexes preoperatively in 25% of our patients. The appearance of CEA immune complexes prove to be a useful prognostic marker with respect to tumor extension since 72/86 patients with CEA immune complexes showed metastasis at the primary resection. The postoperative appearance of CEA immune complexes could be used as an additional parameter for the diagnosis of the relapse; 32/60 patients with a relapse developed CEA immune complexes during the period of surveillance. All patients with localized disease recurrence were found to be free of CEA immune complexes. Detection of CEA immune complexes, however, coincided always with the clinical diagnosis of distant spread of disease. This diagnosis was always preceded by an increase of free CEA and/or CEA immune complexes. In 50/60 patients the relapse could only be demonstrated by clinical methods since these patients stayed CEA-negative throughout the surveillance period.

Adenocarcinoma↗
PubMed1980

The significance of lectin receptors in the kidney and in hypernephroma (renal adenocarcinoma).

Normal kidney tissue as well as hypernephromas were examined histochemically for the occurrence of lectin receptors. FITC- and rhodamine-labeled peanut agglutinin (PNA) and Ricinus communis agglutinin (RCA) were used for labeling different carbohydrate residues which may be of interest in the evaluation of the histogenesis of hypernephromas and possibly for concepts regarding the immunotherapy of these tumors. By using fluorescence microscopy, the receptor for PNA was found on the epithelial cells of the thin limb, distal convoluted tubules, and the collecting ducts. These binding sites occurred in a free as well as in a sialic-acid-substituted form and were mainly exposed on the luminal surface of the epithelial cells. They were absent, however, in the proximal convoluted tubules. This finding contrasts with the demonstration of RCA receptors in the brush border of these tubules. Moreover, RCA reacted with the epithelial cells of all tubules. The hypernephromas showed a wide range in the distribution and the quality of the lectin receptors, which were localized within the cytoplasm as well as in the cell membrane of the tumor cells. As demonstrated by our histochemical investigations, these kidney neoplasms may originate from any part of the tubules, and not only from the epithelial cells of the proximal convoluted tubules, as was suggested by earlier findings that employed antibodies against the brush-border antigens. In addition, the demonstration of sialic-acid-substituted and, in particular, of free PNA-receptors, which represent the immunodominant group of the Thomsen-Friedenreich antigen, may supply useful information on an immunotherapy concept.

Adenocarcinoma↗
PubMed1980

[Noble's operation in relapsing ileus (author's transl)].

Noble's operation was employed in 48 cases. In 33 patients, the operation was performed because of acute ileus. Indication for operations is discussed. Postoperative complications are rare. Two patients died, but there was no direct relationship to Noble's operation. The later operative results are favorable, and no patient has suffered from an ileus relapse.

Adult↗
PubMed1980

[The emergency portacaval shunt in the treatment of persistent hemorrhage from gastroesophageal varices (author's transl)].

From 1963 to March 1980 a delayed portacaval emergency shunt was carried out in 103 unselected patients with persistent hemorrhage from gastroesophageal varices. A portacaval shunt was not performed in patients with hepatic coma and renal insufficiency. Operative mortality was 29% with 10% in cases with risk A, 26% in cases with risk B, and 58% in risk C according to Child's classification.

Acute Kidney Injury↗
PubMed1980

Are circulating CEA immune complexes a prognostic marker in patients with carcinoma of the gastrointestinal tract?

CEA immune complexes and free CEA were determined to 363 patients with histologically confirmed adenocarcinoma of the gastrointestinal tract before surgery and in a post-operative follow-up. Circulating CEA immune complexes (CEA-IC) could be detected preoperatively in 89 patients. Incidence of CEA-IC increased with increasing tumour extension; 72/89 patients with CEA-IC showed already metastatic disease progression, 40/89 had nonresectable tumours. Patients with preoperative CEA-IC had a poorer prognosis than patients without CEA-IC but with high levels of free CEA, or CEA-negative patients. The appearance of CEA-IC with consecutive increases in the postoperative follow-up indicated disease recurrence. In 32/55 relapse cases, circulating CEA-IC were detected postoperatively, all 32 cases developing metastatic spread of disease.

Adenocarcinoma↗
PubMed1980

DNA sequence of regulatory region for integration gene of bacteriophage lambda.

The cII and cIII proteins specified by bacteriophage lambda direct the lysogenic response to infection through the coordinate establishment of repression and integration of the viral DNA. The regulatory activity of cII/cIII involves positive regulation of two promoter sites: the p(E) promoter, turning on expression of the cI protein that maintains lysogeny, and the p(I) promoter, activating synthesis of the Int protein for integrative recombination. Regulation of the p(I) promoter provides for differential expression of the Int protein with respect to the excision-specific Xis protein from the closely linked int and xis genes. We have determined the DNA sequence of the p(I) promoter region for wild-type lambda DNA and for two classes of mutations: intc mutations, which result in a high rate of Int synthesis in the absence of cII, and deletion mutations, some of which eliminate cII-activated expression of the int gene. We find a sequence with considerable homology (11 of 15 bases) to a "typical" (computer-generated) promoter sequence, adjacent to a region with striking homology (11 of 14 bases) to part of the p(E) promoter region. This presumed p(I) sequence overlaps the start of the xis gene and includes the site of two intc point mutations. A cII-insensitive xis(+) deletion partially removes the proposed p(I) sequence; a deletion that leaves the p(I) sequence intact but terminates 21 bases upstream does not interfere with cII activation of the int gene. From our results and the analysis of the p(E) region, we suggest that cII acts in the promoter -35 recognition region to facilitate binding by RNA polymerase at the -10 interaction region. Differential expression of the int and xis genes results because the p(I) transcript lacks the initiation codon for Xis protein synthesis.

Bacteriophage lambda↗
PubMed1980

The effect of regional myocardial ischemia on series elastic and contractile elements of glycerinated heart muscle in dogs.

The response of the contractile and the series elastic elements to ischemia was studied with isometric contraction and quick release methods after measuring the passive length-tension relationship in glycerinated heart muscle fibers of dogs at resting state. Myocardial infarction was induced by ligating left coronary artery. Muscle fibers taken from the ischemic area three hours after ligation demonstrated reduction in maximal developed tension (P0), the maximal rate of tension development (dp/dtmax) and Vmax. The time to peak tension (t0) was increased. As in fresh papillary muscle the modulus of elasticity of active glycerinated muscle increased in proportion to load. The stiffness of the series elastic element elevated significantly in ischemic muscle fibers. The passive stiffness in resting state showed a decrease in the slope accompanied by an increase in the intercept in ischemic heart muscle. Therefore, increased stiffness of the series elastic element and diminished contractility are present following acute myocardial infarction.

Animals↗
PubMed1980

[New technique of liver biopsy (author's transl)].

A new one way set of instruments for liver biopsy (Histocan) dissects a neat cylinder of liver parenchyma harbouring it in a special reservoir. Manipulation of Histocan is very well controllable, independent of timing, and easy to perform, making it an ideal biopsy instrument for laparoscopy. since it is a one way set, sharpening and gliding qualities are invariably good, and better prophylaxis of infection is possible.

Biopsy, Needle↗
PubMed1980

[Partial synchronization and cytostatic combination therapy of disseminated malignant lymphomas of the skin].

Six patients with advanced disseminated malignant lymphomas of the skin were treated with cytostatics using the method of partial synchronisation of the tumor cell growth phases. Though five patients had already shown a resistance against the usual chemo- and/or radiotherapy, all patients responded to this therapeutical principle. Full remission was achieved in four patients. We proved that vincristine effectively synchronizes the growth of proliferating human tumor cells in vivo. Treatment was applied in two steps. First a partial synchronisation of tumor cell growth was induced by vincristine as a pharmacologic means. Then the cytostatics were applied in killing doses at the calculated time. For this purpose we determined the average length of each generation of cells and developed individual therapy schemes. To get the best results with this method usually several therapy cycles were used. In case of a relapse the therapy scheme was adjusted to the altered cellular kinetics. This principal of partial synchronisation is suitable for treating malignant lymphomas with high efficiency, especially those with rapid proliferation even in advanced states.

Adult↗