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Biomedical subjects

R Finn

Publications and source records attributed to R Finn.

At least 109 records · Page 6Linked to original sources
PubMed1980

Apocrine adenoma versus pocrine carcinoma. Report of two cases.

Two examples of apocrine neoplasm are presented, contrasting the features of an apocrine adenoma with those of a possible apocrine adenocarcinoma. Apocrine adenocarcinoma, distinct from Paget's disease, is a rare neoplasm. Its recognition is complicated by long periods of benign growth and by subtle histologic differences from apocrine adenoma.

Adenocarcinoma↗
PubMed1980

Hydrocarbon exposure and glomerulonephritis.

An occupational survey was completed on 87 patients with end-stage renal failure to determine their exposure to hydrocarbon based compounds. 59% of patients with renal failure due to glomerulonphritis had significant contact with hydrocarbons compared with 25% of patients with renal failure due to other causes (P < 0.01). 81% of patients with glomerulonephritis were male and of these 64% had significant hydrocarbon exposure compared with 35% of an age matched control group of male hospital in-patients with no renal pathology. Occupational exposure to hydrocarbons may account for the male predominance in patients with glomerulonephritis.

Adult↗
PubMed1978

New approach to organ transplantation based on the fetal allograft.

A new approach to organ transplantation that may be particularly applicable to kidney transplantation is suggested by analogy with the immunological mechanism responsible for the survival of the fetal allograft. The method concerns identifying donor-recipient tissue compatibility by use of the two-way mixed lymphocyte reaction (MLR), in which reacting cells from patients awaiting transplants are primed with phytohaemagglutinin (PHA) and stored. When a donor becomes available, these PHA-primed cells may then be tested against donor lymphocytes, possibly giving a result within 36 hours. Immunosuppressive agents occurring naturally in pregnancy, such as alpha-fetoprotein and chorionic gonadotrophin, may eventually replace standard immunosuppressive treatment with potentially toxic regimens in transplant recipients. If the results of the two-way MLR using PHA-primed cells are shown to be comparable to those of the standard two-way MLR graft survival may be successful in 80% of cases.

Female↗
PubMed1978

Spontaneous abortion and fetal abnormality in subsequent pregnancy.

In a prospective survey neural tube defects and other congenital abnormalities were studied in the babies born to 510 mothers ascertained during pregnancy. The women were divided into two groups according to the outcome of their immediately preceding pregnancy. Those whose preceding pregnancy had resulted in a spontaneous abortion (256 women) formed the index cases; those in whom the outcome had been a normal baby (254 women) served as controls. There was a highly significant increased number of congenital abnormalities in the index cases. This may possibly be explained by the trophoblastic "rest" hypothesis and suggests that spontaneous abortions are more relevent to congenital abnormalities than has been thought.

Abortion, Spontaneous↗
PubMed1978

"Food allergy": Fact or Fiction?

Six patients with longstanding physical and mental symptoms who had not been helped by many years of conventional medical investigation and treatment experienced immediate relief of symptoms when they avoided certain foodstuffs. This clinical study supports the view that some foods may cause widespread and disabling symptoms in people who are sensitive to them.

Abdomen↗
PubMed1977

Feto-maternal bidirectional mixed lymphocyte reaction and survival of fetal allograft.

Maternal and fetal lymphocytes were tolerant of each other in the bidirectional mixed lymphocyte reaction. This seems to be the principal reason why the mother does not reject the fetal allograft. Tolerance between maternal and fetal cells must be largely due to a genetic mechanism, because the bidirectional mixed lymphocyte reaction between parents and older children was much reduced compared with that between randomly selected pairs of controls. This weak reaction disappeared when immunosuppressive agents were given to one member of the parent/child pair, whereas the mixed lymphocyte reaction between unrelated individuals was not abolished by similar immunosuppression. It is suggested that this genetic mechanism is distinct from the HLA system. Tolerance between maternal and fetal cells was not demonstrated in the unidirectional mixed lymphocyte reaction, suggesting that this tolerance requires the viability of the two cell populations.

Female↗