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Biomedical subjects

R Finke

Publications and source records attributed to R Finke.

58 records · Page 4Linked to original sources
PubMed1975

[Effect of coronary bypass surgery on myocardial pressure and ventricular function in the dog].

In 7 dogs a severe stenosis of the left circumflex coronary artery (CCA) is produced in the course of 18 days. The influence of myocardial revascularization on left ventricular function and on intramyocardial pressures in the areas supplied by the CCA and by the left anterior descending coronary artery is studied. Neither under control conditions nor during acute left ventricular pressure load does opening a bypass graft between the carotid artery and CCA induce a significant change in total ventricular function (dp/dtmax, Vmax, left ventricular enddiastolic pressure). However, immediately after opening the graft intramyocardial pressure rises in the CCA area indicating a regional improvement of myocardial function.

Animals↗
PubMedDate not supplied

The influence of the size of acute ischaemic myocardial lesions on coronary reserve and left ventricular function in the dog.

Acute ischaemic lesions of 5 and 15% of the left ventricular mass were produced in 10 dogs by ligations of branches of the left anterior descending coronary artery. Under maximal coronary dilatation by Dipyridamole and at constant aortic pressure, an ischaemic lesion of 15% caused reductions of blood flow in the left anterior descending coronary artery of 50% (p less than 0.05), , the R. circumflexus of 36% and of total myocardial blood flow (Argon method) by 44% (p less than 0.02). Parameters of left ventricular function, dp/dtmax and Vmax fell by 26 and 27% respectively (p less than 0.02). Ischaemic lesions of 5% LV mass were detected by 133 Xenon clearance estimations, but had no effect on any of the other variables measured. There was good agreement between estimations of total myocardial blood flow (Argon) and direct measurement of coronary flow with electromagnetic flowmeters (r = 0.957).

Acute Disease↗
PubMedDate not supplied

Effect of storage time on the analysis of lymphocyte subpopulations in pleural effusions.

It is not known how long cell surface antigens can be detected on lymphocytes in pleural effusions. Therefore, the lymphocyte subpopulations of 15 native pleural effusions were analyzed after different storage times, at either 4 degrees C or room temperature, using the peroxidase-antiperoxidase adhesive slide assay. No significant differences in the lymphocyte subpopulations were observed after one day of storage under both conditions, although the immunoreactivity with CD4 was poor in the majority of cases stored at 4 degrees C and in two cases stored at room temperature. After three days of storage at 4 degrees C and after four days of storage at room temperature, a marked decrease in lymphocytes attached to the slides was observed. Immunoreactivity with CD8, CD20, CD45 and HLA-1 was well preserved, also, after one week of storage. Reactivity with CD3 was weak or poor after three days of storage in some cases. It is important to recognize that the preservation of the immunoreactivity of lymphocytes is dependent not only on the nutritive quality of pleural fluids but also on the cell preparation method.

Antigens, CD↗