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Biomedical subjects

R Ferrari

Publications and source records attributed to R Ferrari.

At least 469 records · Page 26Linked to original sources
PubMed1978

Dynamic ventriculography with K-strophantin.

Dynamic ventriculography, before and after K-strophantin, was performed in 14 patients with coronary artery disease. Qualitative and quantitative evaluation of hemodynamic and angiographic data has been assessed. Digitalis was found to have different action on asynergic areas--that is improvement in some areas and worsening in others--and little or no action on normokynetic areas. After administration of K-strophantin (0.008 mg/kg), 54% of the examined asynergic zones improved their segmental systolic shortening while 34% worsened or appeared diskynetic. Improvement of asynergic zones could be related to the presence of viable myocardium, while paradoxical systolic motion would suggest the presence of frank fibrosis. Therefore 2 different behaviors of global ventricular function were observed in CAD patients. When ventricular function improves, the values of ejection fraction at midejection show that the improvement is obtained mostly in the first half of ejection. Since heart rate was fixed, enddiastolic volume unchanged and left ventricular systolic pressure increased, it seems likely that the observed changes could be due to a direct inotropic effect of K-strophantin. The author's opinion is that 'strophantin test' could be useful to test whether ventricular function would be enhanced using maintenance digitalis therapy in CAD patients and to determine residual contractile reserve; in addition potential worsening of ejection fraction can be elicited and then a more complete pattern of ventricular function can be provided.

Cardiac Output↗
PubMed1977

[The efficacy of the angiographical method in the evaluation of left ventricular muscle mass in the dog (author's transl)].

In nine closed chest mongrel dogs 42 left ventricular cineangiographies for determination of left ventricular muscle mass were carried out. Buetterich's method was verified and a different procedure of calculation of myocardial wall thickens was proposed. By this method a better correlation line between calculated and weighed left muscle mass and a lower standard error of estimate is obtained.

Angiocardiography↗
PubMed1976

[Imported pulmonary coccidiodomycosis apropos of an anatomo-clinical study].

The case is reported of a 41-year-old Arizona woman who, during a European tour, consulted a Lausanne (Switzerland) physician to whom she reported poor general health and, in particular, localized pains in the right thorax. Although the clinical condition appeared normal, radiology of the thorax revealed a round, hollow shadow in the right lung. Since tuberculosis seemed the most likely diagnosis, the patient underwent antibacillary treatment. Three months later the lesion appeared to have increased in volume, and exploratory thoracotomy was performed with removal of the inferior lobe of the right lung. In the pulmonary parenchyma three greyish, well-defined nodules were found. Exhaustive research disclosed the fungal nature of these lesions through the demonstration of parasitic elements typical of Coccidioides immitis.

Adult↗
PubMed1975

Platelet aggregometry and anti-platelet isoantibodies.

102 sera from polytransfused patients have been screened in platelet aggregometry. Anti-human platelet isoantibodies, tested against 'responsive' human platelets in PRP, give in the aggregometer a decrease in optical density recorded as a sigmoidal curve. In the first step of reaction PF3 availability suggests that the primary action of antibody is to damage the platelet membrane. The second step might be a true aggregation (an ADP-mediated platelet clumping) or a platelet lysis, depending on the type and the potency of antibody, on the type of platelets (normal or thrombasthenic) and on some experimental conditions. These conclusions, confirmed by electron microscopy findings, suggest that aggregometry is a very rapid and simple method of detecting platelet antibodies.

Adenosine↗