Biomedical subjects
Publications and source records attributed to R Ferdani.
A completely synthetic, non-peptide channel has been prepared and shown to conduct cations across a phospholipid bilayer membrane. Studies have been undertaken to assess the compound's location within the bilayer and to better understand its function. These studies are described along with background on the design and concept of the channel.
A number of calix[6]arenes bearing ureas at the upper rim positions of alternate rings 1, 3 and 5 were prepared and studied in detail by NMR spectroscopy and gel permeation chromatography. N-Unsubstituted ureas were shown to dimerize through a cyclic array of hydrogen bonds to give cylindrical cavities capable of encapsulating small molecules such as dichloromethane, benzene and fluorobenzene. Slow equilibria between dimer and monomer were observed in [D6]DMSO-CDCl3 mixtures. By contrast, N-substituted ureas are monomeric. All urea monomers with bulky O-substituents display a solvent-dependent, slow equilibrium between C3v and Cs cone conformations.