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Biomedical subjects

R Faggioni

Publications and source records attributed to R Faggioni.

79 records · Page 5Linked to original sources
PubMedDate not supplied

Proinflammatory cytokines as pathogenetic mediators in the central nervous system: brain-periphery connections.

Cytokines can be produced within the brain and are implicated as pathogenetic mediators of pathologies of the central nervous system (CNS). They cause various CNS effects, inducing fever, anorexia, sleepiness and activating the hypothalamus-pituitary-adrenal axis. Centrally administered cytokines cause peripheral effects such as induction of the synthesis of hepatic acute-phase proteins (APP). Some of their effects (e.g. anorexia, APP synthesis, fever) may result from both central and peripheral actions. Some represent feedback mechanisms that inhibit excess cytokine production.

Animals↗
PubMedDate not supplied

Urinary TNF-binding protein (TNF soluble receptor) protects mice against the lethal effect of TNF and endotoxic shock.

We tested the effect of urinary TNF-binding protein (uTBP) on the toxic effect of TNF (0.5 micrograms/mouse, i.v.) in adrenalectomized mice sensitized with IL-1 to increase susceptibility to TNF. In this experimental model, mortality was 67%, but decreased to 13% when uTBP (250 micrograms/mouse, i.v.) was administered simultaneously with TNF. The protective effect of uTBP was dose-dependent, and time course experiments indicated a protective effect when uTBP was administered before or up to one hour after TNF. Some protection was also obtained when uTBP was given three hours after TNF. Urinary TBP improved the survival of mice after a lethal dose of LPS (1.2 mg/mouse, i.p.), suggesting its possible efficacy in the therapy of septic shock or other TNF-mediated pathologies.

Adrenal Glands↗