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Biomedical subjects

R F Mould

Publications and source records attributed to R F Mould.

At least 37 records · Page 2Linked to original sources
PubMed1981

The role of radiotherapy in the treatment of soft tissue sarcoma: a retrospective study 1958--73.

Survival and local control data are presented for a series of 109 cases of soft tissue sarcoma treated 1958--73. A five-year minimum follow-up period is available. The two-year and five-year survival rates for the complete series are respectively 80 and 68%. In a comparison of survival results for different histological subgroups we found a 94% two-year survival for liposarcomas compared with 80% for fibrosarcomas and 74% for synovial sarcomas; and five-year survivals of 73, 68 and 51% respectively. Sixty-two per cent of the series achieved local control of the disease after initial treatment, and this figure increased to 83% after further treatment. Eighty-six per cent of tumours of the extremities (66/77) were controlled locally without amputation. Of those in the complete series whose disease recurred, either locally or distantly, 50% experienced this recurrence within one year of initial treatment. In only 7% did the recurrence occur more than five years after initial treatment. These results are encouraging and we conclude that they justify an initial treatment policy of conservative surgery combined with radical radiotherapy.

Humans↗
PubMed1981

An assessment of intravenous urogram imaging using 100 mm and conventional films.

A clinical trial was designed to compare the amount of useful diagnostic information obtained from the ten-minute (24 x 30 cm) film of an IVU when using either indirect (100 mm) or conventional radiography. The films for 50 patients were independently examined by ten radiologists. Eight observers considered conventional radiography to be significantly better than indirect (100 mm) radiography, P less than 0.05, and two observers considered that there was no significant difference. Possible applications of indirect radiography are briefly described.

Adult↗
PubMed1979

Clinical trial design in cancer.

The design of clinical trials in cancer is a subject which features reasonably often among FRCR (Part 1) examination questions, and as such should be of more than passing interest to oncologists. It is also a subject which is gaining in relevance since the number of trials is increasing annually due in part to the many chemotherapeutic regimes which are being proposed. This paper which is based on a lecture given in Cambridge at the Hospital Physicists' Association Annual Conference in September 1978, is intended to act as an introduction to clinical trial design. References for further reading are given and, in particular, the extensive report on randomised clinical trials to the Medical Research Council's Leukaemia Steering Committee (Peto et al., 1977, 1978) is recommended.

Double-Blind Method↗