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Biomedical subjects

R F Logan

Publications and source records attributed to R F Logan.

At least 127 records · Page 7Linked to original sources
PubMed1979

Breath hydrogen in pneumatosis cystoides intestinalis.

Pneumatosis cystoides intestinalis (PCI) is an uncommon condition of unknown aetiology. Bacterial gas production may be an important aetiological factor, but experimental evidence in humans has been lacking. We have studied breath hydrogen excretion as an index of bacterial gas production in 12 patients with PCI and have shown that four out of five with demonstrable cysts produced unusually high levels of hydrogen while fasting. This abnormality has not been previously reported. One patient showed resolution of PCI after antibiotic treatment. These findings confirm the importance of bacterial gas production in the pathogenesis of PCI.

Adult↗
PubMed1979

Nurses in the community: a manpower study.

High priority is at present being given to the expansion of health visiting and home nursing services as part of the change of emphasis from institutional to community care. The aim of this study was to provide nurse managers in two regional health authorities with basic information about community nurses with could be used for service planning and development. The results of the study emphasise the particular problems of staffing the community nursing service in inner London, where home nurse and health visitors are younger, more recently appointed, and relatively less experienced than staff in other parts of the regions. High turnover rates and chronic recruitment difficulties in inner London prevent nurse managers from maintaining both the level and the quality of the services they aim to provide. Until these problems are remedied there is little prospect of achieving any significant shift in the balance of care in inner London.

Age Factors↗
PubMed1978

Primary biliary cirrhosis and coeliac disease: an association?

The association of primary biliary cirrhosis and coeliac disease, not previously reported, was observed in 4 patients. In each case, the two conditions were diagnosed simultaneously, and although symptoms were due to coeliac disease, initial investigation drew attention to the liver condition. All the patients responded to a gluten-free diet and remain well 2 years later. Primary biliary cirrhosis remains asymptomatic in 3 patients, but pruritus has developed in the 4th. The significance of this association is unclear and may merit formal study. Coeliac disease should be considered as a possible cause of unexplained weight loss in primary biliary cirrhosis.

Aged↗
PubMed1978

Effect of cimetidine on serum gastrin and gastric emptying in man.

Paired studies of gastric emptying were performed in 10 healthy volunteers using a scintiscanning technique which provides information about the rate of emptying of both the liquid and solid components of a standard meal. Emptying rates of both components were not significantly different after oral administration of 400 mg cimetidine than after placebo. The increase in serum gastrin concentration produced by the meal was significantly greater after cimetidine than after placebo but there was no relationship between individual cimetidine-placebo differences in gastrin response and the corresponding cimetidine-placebo differences in rates of emptying. A positive correlation was demonstrated between the gastric emptying rate of the liquid component and the 1 h cimetidine absorption, indicating that normal individual variation in gastric emptying is probably responsible for much of the normal individual variation in the rate of cimetidine absorption.

Adult↗
PubMed1976

Death in acute upper gastrointestinal bleeding. Can endoscopy reduce mortality?

In a retrospective analysis of 64 deaths from acute upper gastrointestinal bleeding in Edinburgh Royal Infirmary, 46 of the patients (72%) were found to have been over 60 years of age. Recurrent or continuous bledding occurred in 24 cases; after exclusion of deaths from sudden exsanguination (9) and from bleeding varices with subsequent hepatic failure (11), only 4 patients died from recurrent bleeding. Other causes of death were postoperative complications (20) and other severe concomitant disease (20). These results suggest that improved diagnostic techniques such as endoscopy may not significantly reduce the mortality from acute upper gastrointestinal bleeding.

Acute Disease↗