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Biomedical subjects

R F Kilcoyne

Publications and source records attributed to R F Kilcoyne.

74 records · Page 5Linked to original sources
PubMedDate not supplied

Measurement of abdominal fat with T1-weighted MR images.

The cross-sectional area of visceral and subcutaneous fat in the abdomen was measured with T1-weighted spin-echo images acquired with a 1.5-T magnetic resonance (MR) imager. Four axial images centered on L-4 were acquired in each patient. Outline regions of interest (ROIs) were drawn manually for subcutaneous and visceral fat. The subcutaneous fat cross-sectional area was calculated from the ROIs drawn around the outer and inner margins of subcutaneous fat. Several adaptive processing methods were evaluated for measuring fat in the complex structure of the viscera. These methods were compared with an existing MR imaging measurement method for abdominal fat in 18 patients. The adaptive method that uses the valley between the fat and nonfat distributions in the average histogram curve was judged best for research evaluations because it reduces the effects of volume averaging while using a more natural division between fat and nonfat data. Another adaptive method that yielded comparable measurements was thought to be more suitable for clinical applications. Cross-sectional area measurements of abdominal fat were compared in 18 nonobese and 17 obese women to illustrate the utility of these measurements.

Abdomen↗
PubMedDate not supplied

Patterns of muscle atrophy in the lower limbs in patients with Charcot-Marie-Tooth disease as measured by magnetic resonance imaging.

Intrinsic atrophy of the calf musculature is a common finding in Charcot-Marie-Tooth disease. Peroneal nerve atrophy leading to weakness in the anterior and lateral compartments is the most common clinical pattern, but considerable variability exists in the pattern of atrophy. Magnetic resonance imaging offers a valuable method for identifying the distribution and symmetry of muscle degeneration. Twenty-three patients with Charcot-Marie-Tooth disease had axial T-1 magnetic resonance images obtained at proximal, middle and distal calf muscle locations. Areas of fatty infiltration and muscle atrophy were measured in the four calf muscle compartments. The worst areas of involvement, on a scale of one to four, with four being worst, were in the lateral compartment in the mid calf (mean, 2.5) and in the anterior, posterior and lateral compartments of the distal calf (2.6, 2.8 and 2.5). Comparing right and left legs showed that there was visible asymmetry, which was not statistically significant. There was considerable variation in the pattern of involvement from patient to patient. The fact that all four calf muscle compartments may be involved asymmetrically and in varying degrees is important for treatment planning, including surgery. Not all patients have the classic symmetrical peroneal pattern of denervation.

Adolescent↗