A genetic, clinical and psychological study of nine sets of monozygotic twins, discordant for rheumatoid arthritis.
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Biomedical subjects
Publications and source records attributed to R F Jacox.
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A young woman with systemic lupus erythematosus developed a rapidly fatal pneumonia from which no visible or culturable organisms were found. Subsequent stains disclosed typical findings of Legionnaires' disease. A cutaneous portal of entry was suspected and a fulminant lung abscess developed, neither of which has been previously reported in Legionnaires' disease.
A 45-year-old woman developed severe pain in both knees, attributable to subchondral osteolysis of the femoral condyles. A metabolic investigaexcretion disclosed a marked increase in urinary excretion of calcium, hydroxyproline and fluoride. There was an accompanying elevation of erythrocyte sedimentation rate and peripheral eosinophilia. At the height of fluoride tion, fluoride renal clearance was reduced over values determined later when the fluoride excretion was diminished. We speculate that there may have been circulating microcrystals of hydroxyapatite to explain these differences of renal clearance.