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Biomedical subjects

R F Hill

Publications and source records attributed to R F Hill.

At least 37 records · Page 2Linked to original sources
PubMed1974

Mutagenesis by mutator gene mutH1 in continuous cultures of Escherichia coli.

Mutability as a function of growth rate was examined in bacterial strains containing mutator gene mutH1. The rate of mutation to bacteriophage T5 resistance was found to be proportional to rate of growth in glucose-limited chemostat cultures. This finding supports the hypothesis that the mutator mutH1 gene product increases the error frequency during deoxyribonucleic acid replication.

Coliphages↗
PubMed1966

Effect of dark repair on ultraviolet sensitivity of bacteriophage-infected bacteria.

Feiner, R. R. (Columbia University, New York, N.Y.), and R. F. Hill. Effect of dark repair on ultraviolet sensitivity of bacteriophage-infected bacteria. J. Bacteriol. 91:1239-1247. 1966.-Changes in ultraviolet (UV) sensitivity of phage-host complexes during phage development have been studied for the following systems: T1 and Escherichia coli B, T1 and E. coli K-12S, lambda and E. coli K-12S. Complexes were formed with bacterial strains differing in ability to dark-repair UV damage to deoxyribonucleic acid and, after irradiation, were plated on bacteria differing similarly. In the first half of the latent period, the resistance of complexes formed with nonrepairing bacteria increased considerably; with T1 and E. coli B hcr(-), in 4 min the resistance became the same as that of complexes formed with repairing bacteria. The repair ability of plating bacteria affected survival curves only upon irradiation in the second half of the latent period after mature phages were present in the initial complex. Use of nonrepairing bacteria both for initial infection and for plating of late complexes resulted in a series of survival curves showing for all three systems the same pattern of change originally reported for T2-E. coli B complexes. Thus, a hitherto unexplained difference between radiation survival curves for T-even and T-odd phages seems due to repair of T-odd phages by the host.

Coliphages↗