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Biomedical subjects

R F Burns

Publications and source records attributed to R F Burns.

9 recordsLinked to original sources
PubMed1985

Ion-selective electrode technology: an overview.

Diluting a sample before analysis, as is required by both flame photometry and indirect reading ISE analysers, gives less relevant analytical results than measuring an undiluted sample directly. This is because dilution masks the impact that protein and lipids exert on the true activity of an ion in a clinical sample. Measuring a sample directly without dilution enables only those ions which are not bound to other materials, e.g. other ions or proteins, to be detected. The levels of these free ions are more likely to reflect true physiological status than analysis of both free and bound ions. Measuring a sample of whole blood directly without dilution can only be performed accurately if the ISE analyser reference junction is unaffected by changes in haematocrit. Calibrant compositions should be of an ionic strength similar to that of physiological samples. Residual liquid junction potentials between calibrants and samples should be minimised by careful design of the reference electrode.

Autoanalysis↗
PubMed1978

A limited protocol for assessment of within-batch performance of multichannel analysers.

An experimental protocol is described to evaluate rapidly the performance of biochemical analysers. A trial in which this protocol was applied to 15 multichannel continuous-flow analysers is described and the results are discussed. Some consideration is given to the effects of applying a commonly-used drift correction procedure to the raw data, and values of within-batch standard deviation are proposed which may be useful in assessing performance.

Autoanalysis↗
PubMed1977

Declawing the dog.

Explore the source record for details and available documents.

Amputation, Surgical↗
PubMed1977

Detection of pulmonary edema in acute myocardial infarction.

To evaluate methods for detecting pulmonary edema, pulmonary extravascular water volume was measured at 24 hour intervals (total 72 hours) in 25 patients with acute myocardial infarction. Measured lung water was compared with results of clinical, blood gas, X-ray and hemodynamic methods for detecting pulmonary edema. Increased pulmonary extravascular water volume on one or more measurements was observed in 18 of the 25 patients and was associated with an abnormal chest radiograph and increased pulmonary arterial wedge, pulmonary arterial diastolic and right atrial pressures. It was associated less well with clinical, blood gas and other hemodynamic measurements. Pulmonary arterial diastolic or pulmonary wedge pressure was a significant predictor of lung water 24 hours later. Both "preclinical pulmonary edema" and the "therapeutic phase lag" could be predicted from the pulmonary wedge pressure. Clinical, blood gas, radiographic and other hemodynamic measurements were not predictive.

Acute Disease↗