Loratadine: hydroxymethylation in syrup.
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Biomedical subjects
Publications and source records attributed to R Eyjolfsson.
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The formation of two oxidative degradates of diclofenac in solution and the solid state was demonstrated.
The presence of citric acid in the film coating of ranitidine hydrochloride tablets decreased discoloration.
Tablets manufactured from micronized anhydrous nitrofurantoin exhibited unsatisfactory dissolution properties, whereas excellent results were obtained with unmilled drug material having fine particle size.
Matrix tablets manufactured from a practically insoluble drug using Methocel K4M, Methocel K100LV, and mixtures thereof exhibited non-Fickian dissolution properties governed by both diffusion and erosion (value of diffusional exponent in Peppas's transport equation 0.7). The effects of these two hydroxypropyl methylcellulose (HPMC) varieties were nonlinear and antagonistic.
A chemical interaction between lisinopril and lactose was demonstrated and quantified in dilute mixtures in the solid state.