Search PubMed⌕ Search

Biomedical subjects

R Ewers

Publications and source records attributed to R Ewers.

137 records · Page 8Linked to original sources
PubMedDate not supplied

[Resistance of isolated cells from squamous cell carcinomas of the oral cavity to cytotoxic drugs].

Human tumor cells from 22 patients with squamous cell carcinomas of the oral cavity were cultivated in vitro and then subjected to sensitivity tests to cytotoxic drugs such as methotrexate, 5-fluorouracil, cisplatin and bleomycin. Tumor cell proliferation showed drug-specific reaction patterns and time-dose-dependent variations. While the effect of methotrexate on cell proliferation was insignificant, 5-fluorouracil caused a growth suppression of 50%. Cisplatin and bleomycin suppressed cell growth by more than 90%.

Antineoplastic Agents↗
PubMedDate not supplied

[Conclusiveness of various diagnostic procedures for squamous cell carcinomas of the visceral cranium and the oral cavity as compared with histological evaluations].

In 60 patients with primary squamous cell carcinomas of the oral cavity, clinical examination was complemented by 5 additional diagnostic procedures prior to surgery to assess tumor extension. Comparing these finding with the histological evaluation of the excised tissue demonstrated that, while the TNM classification remains the foundation of all tumor diagnostic procedures, the use of radiography, bone scintigraphy and CT is indispensable to ascertain the amount of tissue to be excised. CT competes with B-scan sonography in cervical lymph node diagnostics. Tumor scintigraphy has been found to be an unreliable method.

Aged↗
PubMedDate not supplied

[Growth of oral epithelia in cell groups in vitro. Approaches and possible methods].

Various possible methods and own experimental approaches to the production of an autogenous, two-layer epithelialdermal replacement of the mucous membrane are reported. The results of the cultivation of human mucosal epithelia in vitro are presented and the basic requirements this material should meet are discussed.

Culture Techniques↗