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Biomedical subjects

R Engelbrecht

Publications and source records attributed to R Engelbrecht.

15 recordsLinked to original sources
PubMed1991

[Drug interactions in the prescriptions of patients before and after a heart infarct: results of the MONICA Augsburg heart infarct registry].

The prescriptions of 603 patients who had survived acute myocardial infarction (AMI) for at least one year and were registered from 1 Oct 84 to 31 Dec 86 in the Coronary Event Register of the MONICA project Augsburg were analyzed for the presence of drug-drug interactions with the aid of a computerized drug information system (SMA). Prior to AMI, 59% of patients were treated (average of 2 active substance per patient), 100% were treated on release from hospital (4.5 active substances), and 96% one year after AMI (5.8 active substances). Potential drug-drug interactions were found in 18% of patients before AMI, 65% on discharge from hospital, and 66% one year after AMI. While the potential frequency and severity of interactions are minor on average, prescriptions frequently contain several interactions. Calculations show that at least 5-6% of all prescriptions after AMI will produce interactions, so that drug safety for this high-risk patient group can be enhanced by a drug information system. Beta-blockers are the substance group most frequently involved in potential interactions in AMI patients.

Adult↗
PubMed1990

Analysis and processing of data in a hospital-based diabetes management system.

Both short-term care (blood glucose monitoring) and long-term care (clinical examinations) of diabetes generate an ample amount of data for each patient. Health care in hospitals has to provide services with respect to both demands. The quality of control depends on obtaining the right finding at the right time and taking the individually adequate measures. These repetitive activities follow to a certain extent standardized algorithms and computer-programs are able to support demands like this; however, up to now no attempts have been made to provide useful tools for this environment. DIALIN is a data-bank especially designed for the use in hospitals or outclinics and Camit is a diabetes management system for advanced evaluation of long-term blood glucose monitoring data. The expert-system DIACONS up to now determines diabetes type and adequate initial therapy from data of patients' history alone; it operates on the DIALIN-databank via SQL. DIALIN has proven to be a useful tool for data-processing in hospitals. Camit was well accepted by patients in a feasibility study. DIACONS has been tested with 83 diabetic patients to provide the correct diabetes-type and the proper initial regimen with a precision of 96% compared to the correspondence between two independent experts. The combination of all three systems is a step towards the Munich Medical Information system MAMIS.

Blood Glucose Self-Monitoring↗
PubMed1988

[Abnormalities-retardation syndrome caused by incomplete triploidy].

We report on a four year old boy with multiple congenital anomalies and mental retardation due to incomplete triploidy (diploid triploid mixoploidy). Initially, we had thought of the Silver-Russell syndrome. The main characteristics in the patient are short stature, body asymmetry, hypogenitalism, and considerable mental retardation. In addition, there are several minor anomalies of the hands and feet. The diagnosis was verified by microscopic detection of a triploid cell line in cultivated skin fibroblasts and by supplementary studies using flow cytometry. The characteristics of this recognizable multiple congenital anomalies/mental retardation syndrome are discussed with reference to the pertinent literature. As differential diagnosis, in particular the Silver-Russell syndrome has to be taken into account.

Abnormalities, Multiple↗
PubMed1986

[Coffin-Siris syndrome in a 5-year-old girl].

A 5 1/2 year old female patient with Coffin-Siris syndrome is described. This syndrome is characterised by multiple congenital anomalies and mental retardation. The important clinical features include postnatal growth retardation, microcephaly, considerable psychomotor retardation, coarse facies with thick lips, sparse scalp hair with hypertrichosis of the face and body, as well as hypoplasia or even aplasia of distal phalanges of fingers and toes. Chromosomal aberrations, which could be considered as differential diagnosis are excluded by the finding of a normal karyotype. The aetiology or pathogenesis of this syndrome are not really known.

Abnormalities, Multiple↗
PubMed1976

[Acute occlusion of the arterial blood supply of the right arm in a newborn following entanglement of the umbilical cord (author's transl)].

Report on the rare event of a complete ischemia of the right arm immediately postpartum. The infant was delivered by Caesarean Section because of cervical dystocia and fetal distress. The umbilical cord was twice around the neck and the ischemia of the right arm appeared to be due to spasm of the axillary artery. Treatment for shock and infusion of vasodilating drugs (Complamin) relieved the arterial spasm.

Arm↗