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Biomedical subjects

R Elias

Publications and source records attributed to R Elias.

50 records · Page 3Linked to original sources
PubMed1980

[Job tasks and occupational diseases in data processing].

The industrial organisational model of repetitive work, a consequence of Taylor type rationalization, is encountered in datra computerized processing sectors, especially for data input tasks, with the same effects: pressure of time, monotony, insatisfying work. a group of data collecting female operators was investigated and compared to a group of female operations whose activities included computer dialoguing, a more complex task. Recordings of eye movements for the analysis of perceptive and cognitive aspects of the task, as well as questionnaire concerning the effect of factors such as stress in their lives, and the possible presence of psychosmatic and nervous symptoms, were used. The resulting data showed the task content impact upon the life at work and its more harmful effect on the mental and bodily comfort of data input operators.

Adult↗
PubMedDate not supplied

In vitro activity of the beta-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum.

Harmane, harmine, and harmaline were investigated for their in vitro antileishmanial activity toward parasites of the species Leishmania infantum. Harmane and Harmine displayed a moderate antiproliferative activity toward human monocytes and exerted a weak antileishmanial activity toward both the promastigote and the amastigote forms of the parasite. Their mechanism of action on the promastigote form of the parasite involved interactions with DNA metabolism leading to an accumulation of parasites in the S-G(2)M phases of the cell-cycle. Harmaline, at the contrary, was deprived from toxicity toward human cells and Leishmania promastigotes, however it exerted a strong antileishmanial activity toward the intracellular amastigote form of the parasite. This property was shown to partly result from the capacity of the molecule to prevent parasite internalization within macrophages by inhibiting Leishmania PKC activity.

Animals↗
PubMedDate not supplied

[Chronic suppurative otitis media. Experience with 140 cases at the Hotel-Dieu of France].

OBJECTIVES: Chronic suppurative otitis media (CSOM) is a common disease especially in developing countries. In Lebanon, CSOM is a frequent complaint. This retrospective study is an objective evaluation of the cases we operated in HDF. METHODS: One hundred and forty cases of CSOM were collected between 1993 and 1997: 88/140 cases were simple CSOM and the others 52/140 cases had cholesteatomas. RESULTS: There were no immediate postoperative complications reported (< 6 weeks). Beyond 6 weeks, with a mean follow-up of 20 months, 15% of the patients were lost for follow-up and we had 93.4% of success rate in CSOM and 88% in cholesteatomas. The recurrence rate of cholesteatoma was 14%. Children's cholesteatoma (below 15 years of age) were more aggressive than adult's cholesteatomas. In CSOM without cholesteatoma, the hearing gain was 5 dB. In CSOM with cholesteatoma the mean hearing gain was 4 dB. In conclusion the study revealed the importance of this pathology in our country with the relative high incidence of cholesteatoma compared to simple CSOM, this could be explained by the chronicity of the disease and the lack of preventive measures.

Adolescent↗
PubMedDate not supplied

Preparation and use of morphine capsules in paediatric patients with burns.

Morphine is an analgesic agent used for the symptomatic relief of moderate to severe pain. The lack of oral paediatric form of morphine hydrochloride has led the pharmacy unit to develop capsules containing 1 mg of morphine. These capsules are prepared in conformity with G.M.P. and controlled by H.P.L.C. 73 burn children were treated in this study with pain suppression without adverse effects. This galenic form may be an adequate candidate for the management of paediatric patients because of its analgesic qualities and of numerous advantages.

Burns↗