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Biomedical subjects

R Ehrlich

Publications and source records attributed to R Ehrlich.

At least 325 records · Page 18Linked to original sources

The use of intravenous isoproterenol in the treatment of status asthmaticus.

The use of intravenous isoproterenol in nineteen children with status asthmaticus who did not respond to standard anti-asthmatic therapy is reported. Six of the fourteen patients who responded favorably had normal blood gases within six hours ten within twelve hours and twelve within eighteen hours; all fourteen of the patients who responded favorably had normal blood gases within twenty-two hours after the drug was begun. Clinically, eleven of the fourteen patients who responded favorably showed improvement in respiratory distress within twelve hours of the institution of therapy. All patients who responded favorably showed some improvement within twenty-eight hours of treatment. There were five treatment failures; two were due to cardiovascular toxicity of isoproterenol, and three to progression in symptomatology that necessitated continuous ventilation with respirators.

Adolescent↗

Pediatric cardiac resuscitation team: a 6 year study.

A cardiopulmonary resuscitation team based in the pediatric intensive care unit responded to 239 cardiac arrests over a 6 year period. Patients with respiratory problems and infectious diseases requiring isolation composed the largest groups in whom unexpected arrests occurred. There was a 78 per cent rate of initial response to therapy and a 47 per cent survival rate. This is almost twice the survival rate of the best previously reported study and five times the average.

Cardiopulmonary Resuscitation↗

Nerve conduction in childhood diabetes.

Sixty-nine diabetic children were studied with respect to the motor nerve conduction velocities, duration of illness and adequacy of control.As a group there was a trend for children with diabetes to have slower MNCV than non-diabetic children, and for the slowing to become progressive as the duration of their disease increased. Poorer quality of diabetes control was also associated with progressive slowing of conduction but the exact relationship is uncertain, since no patient who had diabetes for more than four years was well controlled.Theories of causation of peripheral neuropathy in diabetic patients are reviewed; metabolic changes, rather than other factors, are thought most likely in children.

Adolescent↗

Survival of airborne Pasteurella tularensis at different atmospheric temperatures.

The aerosol survival, recovery, and death rate of Pasteurella tularensis SCHU S5 disseminated in particle sizes of 1 to 5 mum were significantly affected by air temperature. The highest aerosol recovery of viable P. tularensis was observed within -7 and 3 C; the recovery decreased significantly below and above this temperature range. The death rate of airborne P. tularensis was not significantly influenced by an increase in temperature from -40 to 24 C. However, a progressive increase in atmospheric temperature from 24 to 35 C resulted in increased death rates; thus, a linear relationship appeared to be present between the temperature and death rates. At 49 C, the recoveries of viable airborne P. tularensis were significantly lower and the death rates were higher than at the other temperatures.

Aerosols↗

Effect of NO 2 on airborne Venezuelan equine encephalomyelitis virus.

Studies were conducted to determine the effect of nitrogen dioxide (NO(2)) on aerosol survival and biological decay rate of Venezulean equine encephalomyelitis (VEE) virus and spores of Bacillus subtilis var. niger. The NO(2) concentrations used in the experiments were 0.5, 5, and 10 ppm at 24 C and 85% RH. The survival of airborne VEE virus disseminated as particles 1 to 5 mum in diameter was significantly influenced by the presence of 5 ppm of NO(2). At this concentration, the biological decay rate increased threefold and the aerosol recovery and aerosol survival of the VEE virus were significantly lower than at 0.5 ppm or in the absence of NO(2). Airborne spores of B. subtilis were not significantly affected by as much as 10 ppm of NO(2).

Aerosols↗

Effect of relative humidity and temperature on airborne Venezuelan equine encephalitis virus.

Inactivation of airborne Venezuelan equine encephalitis (VEE) virus disseminated from liquid suspensions or from lyophilized preparations as 1- to 5-mum particles was investigated under various conditions of relative humidity and temperature in a 2,500-liter static aerosol chamber. Relative humidity ranging from 18 to 90% at 24 C and temperature ranging from -40 to 24 C had no marked effect on the biological decay rate or the recovery of viable airborne VEE virus disseminated from liquid suspensions. However, at 49 C a significant increase in the biological decay rate and decrease in aerosol recovery of the VEE virus were observed. Airborne lyophilized VEE virus was significantly affected by relative humidity. An increase in relative humidity from 20 to 90% resulted in progressive decrease in aerosol recovery of viable VEE virus. A twofold reduction in aerosol recovery of the lyophilized virus was observed at and above 29 C as compared to the lower temperatures studied. However, the differences among biological decay rates of lycphilized VEE virus were not significant within temperature range of -40 to 38 C.

Air Microbiology↗

Relationship between atmospheric temperature and survival of airborne bacteria.

Effects of temperatures ranging from -40 to 49 C on the behavior of airborne Serratia marcescens, Escherichia coli, and Bacillus subtilis var. niger were investigated. Aerosol decay rates of B. subtilis spores were not significantly affected by the temperature and remained approximately constant within the temperature range studied. The survival of airborne S. marcescens and E. coli was closely related to the temperature. An increase in temperature from -18 to 49 C resulted in a progressive increase of the biological death rate, and the relationship between the biological death rate and the temperature appeared to be linear. An increase in temperature from 24 to 49 C resulted in significantly reduced aerosol recoveries of the two vegetative organisms. At -40 C, the aerosol recovery of all three agents was consistently lower than at -18 to 24 C.

Aerosols↗

Effects of atmospheric humidity and temperature on the survival of airborne Flavobacterium.

The survival of airborne Flavobacterium sp. in particle sizes ranging from 1 to 5 mum was significantly influenced by atmospheric temperature. A progressive increase in temperature from -18 to 49 C resulted in increases in death rates of the airborne organism. The lowest death rates were observed in the temperature range of -40 to -18 C, and the highest death rates were observed in the 29 to 49 C range. At 24 C, the survival of airborne Flavobacterium did not appear to be significantly affected by relative humidity ranging from 25 to 99%.

Air Microbiology↗