Biomedical subjects
R Edmonds
Publications and source records attributed to R Edmonds.
Cough with green sputum.
Good treatment often involves advice on lifestyle modification which may be more important in the long run than pharmacological intervention alone. Compliance, however, is always a problem. Some patients refuse to take responsibility for their own health but repeatedly present to the GP to be patched up. The persistent smoker with recurrent bronchitis is just such a patient, but what can the conscientious GP do?
Pneumococcal polysaccharide immunization of children with sickle cell disease. II. Serologic response and pneumococcal disease following immunization.
One-hundred seventy-four children with sickle cell disease (SCD) were immunized with a single dose of tetradecavalent pneumococcal vaccine. Preimmunization and postimmunization antibody against 13 of the 14 pneumococcal capsular antigens was measured by indirect hemagglutination (IHA). The ability of each antigen to stimulate antibody following immunization was characterized by one of three types of responses: (1) poor antibody response regardless of the age at immunization (capsular types 6A, 14, and 19F); (2) improving antibody response with advancing age at immunization (capsular types 1, 4, 9N, 12F, 18C, and 23F); and (3) good antibody response regardless of age at immunization (capsular types 2, 3, 7F, and 8). An increase in antibody following immunization was significantly correlated (P less than 0.0005) with an increasing level of preimmunization antibody titer for all 13 antigens. Through the first 24 months of study, two episodes of pneumococcal sepsis caused by group 23 pneumococci were documented in two children immunized prior to 24 months of age (incidence rate, 4.40/100 patient-years in children less than 5 years of age), and one additional episode caused by a group 23 pneumococcus occurred in a 5 7/12-year-old child (incidence rate, 0.66/100 patient-years in children greater than 5 years of age). These observations suggest that anamnestic immune response significantly contributed to the enhanced antibody response observed in older children and adults. Only modest vaccine efficacy may be expected among children with SCD who receive a single dose of pneumococcal vaccine.
Death from type 6 pneumococcal septicemia in a vaccinated child with sickle-cell disease.
Explore the source record for details and available documents.
The mortality of young children in western Australia: the Aborigines' contribution.
Explore the source record for details and available documents.
The mortality of young children in Western Australia: the aborigines' contribution.
Explore the source record for details and available documents.