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Biomedical subjects

R E Thach

Publications and source records attributed to R E Thach.

82 records · Page 5Linked to original sources

Formylmethionine codon AUG as an initiator of polypeptide synthesis.

Oligonucleotide messengers containing the sequence AUG at or near the 5' end of the chain stimulate the incorporation of N-formylmethionine,but not of free (unformylated) methionine. AUG is considerably more active in this regard than UUG, the other N-formylmethionine codon. The coding activity of subsequent in-phase triplets in the 3' direction from AUG is markedly stimulated by this codon.

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