Biomedical subjects
R E Russell
Publications and source records attributed to R E Russell.
Laron-type dwarfism is associated with normal growth hormone and insulin-like growth factor I gene restriction patterns.
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Water environment microwave thawing.
A rapid, controlled microwave oven thawing technic for fresh frozen plasma (FFP) that minimizes flocculent formation while maintaining excellent coagulation factor, total protein, and albumin levels is presented. This method, using an unmodified microwave oven and a tap-water environment, decreases thawing time from 37.5 minutes for the standard 37 degrees C water bath to approximately 11 minutes for either one or two units of FFP.
Inhibitory effect of cardiac contraction on coronary collateral blood flow.
The present study was undertaken to determine the effect of contraction on overall flow in an area supplied by collateral vessels. Changes in the distribution of blood flow across the wall of ischemic and normally perfused regions of the left ventricle were observed during normal beating and during vagal arrest. The main left coronary artery was cannulated and perfused at constant pressure (125 mmHg) using a servo pump apparatus. An ischemic area supplied by collaterals was created by ligating the left anterior descending artery. Radiomicrospheres (15 micrometer) were injected into the perfusion apparatus during beating. Then spheres with a different label were administered to the same heart during arrest. The results revealed that beating caused a gradient of blood flow inhibition from near zero at the epicardium to about 50% at the endocardium in both zones. Inhibition to flow at the mid wall of the ischemic zone, 71%, was significantly greater than that seen at the corresponding depth in the normally perfused region, 33%. These results indicate that contraction not only inhibits collateral blood flow to an ischemic region, but also that the inhibition is actually magnified at the mid wall.