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R E Pearson

Publications and source records attributed to R E Pearson.

At least 73 records · Page 4Linked to original sources
PubMed1987

Hospital diversification: bibliography on pharmaceutical services.

A pharmacy diversification bibliography is presented. The bibliography includes a selection of references to descriptive reports, research papers, editorials, letters, and commentaries on diversified pharmaceutical services. This bibliography represents important literature from the past 12 years on diversification strategies as well as specific diversified services. For additional information, references have also been included to articles that suggest opportunities for diversification, describe pharmacists' roles in specific services, discuss legal or reimbursement aspects of a service, or could be used to help justify the implementation of a service or "sell' a service to hospital administrators or consumers. The bibliography can be helpful to pharmacy managers and clinicians who are interested in becoming involved in diversification of pharmaceutical services.

Bibliographies as Topic↗
PubMed1986

Effect of genetic selection for milk yield and increased milking frequency on plasma growth hormone and prolactin concentration in Holstein cows.

Fifty Holstein cattle, either second to fourth generation daughters of cows randomly bred to non-commercial sires originating in the Virginia Tech dairy herd (estimated mean PDM84 = -455 kg, control animals), or daughters of cows bred to commercially available sires (mean PDM84 = +368 kg, selection animals), were randomly assigned to be milked twice or thrice daily starting at parturition. Serial blood samples were collected via jugular cannulae at 30, 90 and 200 d post-partum (DPP) during both the first and second lactations. Blood samples were collected for 3 h prior to and 4 h following thyrotropin releasing hormone (TRH) administration, and were analyzed for growth hormone (GH) and prolactin (PRL) concentrations. Dry matter intake, body weight and milk yield and fat content were used to calculate net energy balance (NEB) of animals at each DPP sampling period. Mean plasma GH concentrations were greater (P less than .01) in selection vs control animals both before and after TRH administration, and decreased (P less than .01) with advancing lactation (30 greater than 90 greater than 200 DPP). However, NEB was not influenced by genetic merit, implying that observed differences in GH concentrations were not due to that trait. Plasma PRL concentrations were not affected by genetic merit or DPP, but were greater (P less than .01) in the second vs first lactation. Neither PRL or GH concentrations were affected by frequency of milking. The results support the contention that increased plasma GH concentrations are associated with selection for increased milk yield.

Animals↗
PubMed1986

Pharmacy financial management.

This study was undertaken to aid Blue Cross & Blue Shield of Alabama in determining an equitable dispensing fee and to examine profitability in the study pharmacies. A 25 percent random sample of community pharmacies (independent, chain, professional, and independent discount) in Alabama was studied, indicating an average breakeven cost to fill a prescription of $3.04. Pharmacy profitability was derived from the prescription department, with the front-end merchandise (all non-prescription items) contributing negatively to profitability in the average community pharmacy.

Alabama↗
PubMed1986

Effect of season and stage of lactation on plasma insulin and glucose following glucose injection in Holstein cattle.

Changes in plasma glucose and insulin concentrations following glucose injection in dairy cows (six per stage of lactation per season) were characterized during early, middle, and late lactation in winter, spring, and summer. Blood samples were collected 60, 45, 30, 20, 15, 10, 5, and 0 min (period 1) before glucose injection (.1 g/kg body weight) and at 5, 10, 15, 20, 30, 45, and 60 min (period 2) after injection. Plasma insulin concentrations were affected by season, period, season by period interaction, and time within period. Plasma glucose was affected by period, time within period, and stage of lactation by period interaction. Insulin was lowest in summer. Magnitude of insulin response to glucose was highest in spring. Both plasma glucose and insulin increased significantly 5 min following glucose injection. Peak glucose concentrations increased with advancing lactation. Results indicate alterations in glucose metabolism as well as changes in insulin sensitivity to glucose in various seasons and stages of lactation.

Animals↗
PubMed1986

Somatic cell counts and infection rates for cows of varying somatic cell count in initial test of first lactation.

Somatic cell counts (log, base 2) and rates of infection in first and subsequent lactations were examined by classes of somatic cell count in initial test day of first lactation to determine if cows with initially low counts were more at risk to subsequent mastitis infection. Classes of initial somatic cell counts were less than 100,000, 100,000 to 400,000 and greater than 400,000. Differences among initial classes in subsequent cell counts were small, but the initial rank of classes was maintained throughout the remainder of first lactations and in subsequent lactations. Differences among initial classes for rates of infection in first and subsequent lactations consistently favored low initial cell counts. Results gave no indication that cows initially low in cell count are at greater risk of subsequent mastitis infection.

Animals↗
PubMed1986

Genetic methods of improving dairy cattle for the south: a review and prospects from Regional Project S-49.

Objectives of Southern Regional Research Project S-49, comprising eight contributing experiment stations, are to determine direct response to selection in milk and the resultant correlated responses in nonyield traits, to define and evaluate selection criteria for total economic merit or profit, to quantify genetic and environmental components of underlying physiological characters responsible for genetic gains in economically important traits, to determine interactions of genotype by environment, and to estimate genetic values for males and females. More than 150 scientific articles from S-49 have been published in journals from 1975 to 1985. These results have contributed in a major way in identifying issues and understanding the genetic control of cow performance and economics of genetic improvement programs.

Animals↗
PubMed1986

Potential of somatic cell concentration in milk as a sire selection criterion to reduce mastitis in dairy cattle.

Lactation records for somatic cell counts in milk, bacteriological culture results, antibiotic treatment for mastitis, and production were formed for cows in 30 cooperating dairy herds in Virginia. A second data set, including somatic cell counts and production information for cows in approximately 400 herds in Virginia (not including the original 30), was used to evaluate sires genetically for somatic cell count. Approximate genetic correlations between measures of cell count and measures of infection ranged from .36 to .67. These were highest (lowest) for frequency of infection by major (minor) pathogens. Corresponding phenotypic correlations were similar but slightly smaller. Neither somatic cell counts nor measures of infection were well correlated with treatment. Production traits generally had small, negative genetic and phenotypic relationships with cell counts, rates of infection, and measures of treatment. Correlations for evaluations of sires for cell count were positive with daughter averages for infection rates (.20 to .38) and treatment measures (.02 to .13). Largest (absolute value) correlations between evaluations of sires for cell count and production traits were for fat percentage (-.38) and fat yield (-.28). Evaluation and selection of sires for decreased somatic cell count may augment management and treatment programs in the reduction of mastitis incidence.

Animals↗
PubMed1985

A physical domain of herpes simplex virus ICP8 is expressed and active in Escherichia coli.

In this report, we describe a series of procedures to assay the function of fusion genes in Escherichia coli and the specific application to the carboxy-terminal third of the herpes simplex virus type 1 (HSV-1) DNA-binding protein ICP8. E. coli cells containing the cloned HSV-1 BamHI G fragment with the HSV-1 BamHI-G-V site, map unit 0.388, nearest the tet promoter in pBR322 synthesized an active product containing a portion of ICP8. The new product induced phenotypic alterations in recipient hosts that were measurable and stable yet limited to the stability of the plasmid. The corresponding cloned DNA from the characterized HSV-1 DNA-binding protein mutant tsHA1 exhibited a predictable temperature-sensitive phenotype. Screening procedures based on the loss of induction of the parental plasmid-induced phenotype in E. coli cells allowed us to select additional mutations. One of these, which conferred a phenotype different from that of tsHA1, was transferred to the viral genome by marker transfer techniques. We suggest that any mutant could be isolated in any sequence, provided that the wild-type coding sequences induce alterations in E. coli cells. The observed alterations should have relevance in determining the mode of action of the protein in its normal environment.

Cloning, Molecular↗
PubMed1985

Drug information roots: the influence of education and training on the philosophy and activities of hospital- and pharmacy school-based drug information services.

The objective of this project was to assess influences of past and present educational and training experiences on the development of drug information services. A questionnaire was used to collect information concerning the respondent's location, educational background, and relationship to others in the field. Next, demographic characteristics of the service were collected. The final section had respondent's rank 26 activities for both current scope of activities and the individual's philosophy of practice. Respondent's were asked to prioritize each activity according to contribution, directly or indirectly, to patient care. This study did not identify a major potential source of educational or training influence. However, despite the apparent lack of a major educational or training influence on the profession there is evidence to suggest that such influences can affect the scope of activities within services or the philosophy of practice of individuals. The differences in rankings commonly observed for the scope of activities support the observation of lack of equivalence in earlier studies.

Drug Information Services↗
PubMed1985

Influence of selection for milk yield on endogenous hormones and metabolites in Holstein heifers and cows.

Plasma concentrations of prolactin (PRL), growth hormone (GH), insulin, glucagon, glucose, urea and free fatty acids (FFA) were measured in Holstein calves, yearlings, bred heifers and primiparous cows, either sired by bulls with high predicted differences (PD) for milk (selection group) or by bulls from an unselected random bred control population (control group; n = 6). Serial blood samples were collected before and after feeding for an 8-h period from 0900 to 1700 h. All animals were fed a complete feed at 1100 h and administered insulin (.6 IU/100 kg body weight) at 1400 h. Mean plasma PRL was greater in control animals after feeding and insulin administration, while GH was greater overall in selection cattle. Insulin remained elevated longer in selection animals after exogenous administration, and plasma glucagon was increased in the control group. While plasma glucose and urea were unaffected by genetic group, plasma FFA were elevated in selection group calves and primiparous cows compared with the control group. All hormones and metabolites differed among the pre- and post-feeding and insulin administration periods and also with age. Mean PRL and GH increased after feeding, while glucagon decreased after exogenous insulin. Plasma FFA declined after feeding, while urea and glucose were similar before and after feeding. Mean PRL increased and glucagon decreased with advancing age and plasma GH and insulin showed inverse relationships at different ages. Plasma FFA changes closely followed GH changes with age, while plasma glucose more closely followed insulin changes with age. Results indicate that all hormones measured and FFA responded to genetic selection for milk, and increases in GH are uniformly associated with increased genetic potential for milk yield.

Animals↗
PubMed1985

Glucagon, insulin, growth hormone, and glucose concentrations in blood plasma of lactating dairy cows.

Concentrations of glucose, growth hormone, insulin, and glucagon in blood plasma relative to days in milk, milk production, type of housing, and season were measured. Blood samples were obtained from 133 to 150 lactating Holstein cows on 3 consecutive days in July, October, January, and April. Glucose, insulin, and ratio of insulin to glucagon increased with increasing days in milk. Growth hormone and ratio of growth hormone to insulin decreased with increasing days in milk. Glucagon concentrations were similar throughout lactation. Above average milk production throughout lactation was associated with above average glucagon, lower insulin, and lower glucose. The relationship was not significant between growth hormone concentration and milk production, however. Cows on summer pasture with limited grain supplement had higher growth hormone and lower glucose, insulin, and glucagon than cows eating ad libitum in barns or feedlot. In general, however, all cows had higher glucose and lower growth hormone, insulin, and ratio of insulin to glucagon in July than in cooler months.

Animal Feed↗
PubMed1985

Genetic and phenotypic relationships among type traits scored linearly in Holsteins.

Phenotypic and genetic parameters were estimated for 12 type traits of Holstein cows scored linearly by personnel of an artificial insemination organization. Estimates were compared with those from programs offered by the breed association and by two other artificial insemination organizations. All programs were based on scoring guidelines of the National Association of Animal Breeders. Heritabilities of linear type traits ranged from .40 for stature to .14 for fore udder attachment with heritabilities for udder traits smaller than for nonudder traits. Largest genetic and phenotypic correlations were among udder traits with genetic correlations consistently exceeding phenotypic correlations. Similarities in relative magnitudes of phenotypic and genetic parameters suggest that linear type appraisal programs do not differ greatly among organizations using scoring guidelines of the National Association of Animal Breeders.

Animals↗
PubMed1985

Components of genetic variance and covariance for linear type traits in Jersey cattle.

First available appraisals for 67,644 Jersey cows were used to estimate relative magnitudes of additive and selected sources of nonadditive genetic variance and covariance for 13 type traits scored linearly from 50 to 99 points. Covariances among four types of relatives were used to estimate components of genetic variance and covariance for each of the 13 traits. Direct additive, direct dominance, and additive maternal genetic variances and the direct-maternal additive genetic covariance were estimated using covariances among paternal half-sibs, full-sibs, daughters and dams, and maternal half-sibs. Estimates of additive genetic variance were 11 to 36% of variance within herd-appraiser subclasses with largest values for stature, strength, rump angle, rump width, and udder depth. Dominance components were two to four times the magnitude of additive components for dairy character, rump width, fore udder, rear udder height, rear udder width, and suspensory ligament but much smaller for other traits. Maternal effects and the direct-maternal additive genetic covariance appeared small for all linear type traits.

Animals↗
PubMed1985

Factors affecting ability of skim milk to support phagocytosis by bovine polymorphonuclear leukocytes.

Milk samples from quarters were collected from 48 Holstein cows at 1.5, 3, 21, and 35 wk postpartum and at 1 wk after drying off. Foremilk samples were obtained for bacteriological examination, somatic cell count of milk, and for assay of phagocytosis. Thirty-two cows in first lactation and 16 in third lactation produced by two criteria of sire selection (high milk versus multiple trait) were studied. In vitro phagocytosis was assayed four times on each original quarter milk sample, yielding 3,840 determinations. Variance components were large for cow-associated variation. Cow, stage X cow, and cow X sample dilution were 18.7, 20.6, and 6.0% of total variance. Phagocytosis was 9% higher in skim milk from third lactations than from first. Phagocytosis was highest in dry period samples, followed by 1.5, 35, 3, and 21-wk postpartum samples. Milk somatic cell count tended to be related more closely to phagocytosis than was current bacteriological status of the quarter. Skim milk from genetically higher producing cows was less conducive to phagocytosis than skim milk from genetically lower producing cows, possibly because of dilution.

Animals↗