Interspecies "transfer" of delayed hypersensitivity in vitro with RNA extracts.
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Adjuvants, Immunologic↗
Biomedical subjects
R E Paque
Publications and source records attributed to R E Paque.
In vitro studies with "transfer factor". II. Transfer of the cell-migration inhibition correlate of delayed hypersensitivity in humans with nondialyzable components of leucocyte lysates from humans sensitized to histoplasmin and coccidioidin.
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Antigens, Fungal↗
Transfer of tumor-specific delayed hypersensitivity in vitro to normal guinea pig peritoneal exudate cells using RNA extracts from sensitized lymphoid tissues.
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Animals↗
Monkey to human transfer of delayed hypersensitivity in vitro with RNA extracts.
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Animals↗
Interspecies "transfer" of delayed hypersensitivity in vitro with RNA extracts.
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Animals↗
In vitro studies with "transfer factor": transfer of the cell-migration inhibition correlate of delayed hypersensitivity in humans with cell lysates from humans sensitized to histoplasmin, coccidioidin, or PPD.
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Cell Movement↗
Modulation of murine coxsackievirus-induced myocarditis utilizing anti-idiotypes.
Pre-treatment of syngeneic mice with polyclonal populations of Protein-A separated anti-idiotypic antibodies prepared against anti-CVB3 viral idiotypes resulted in reduction of inflammatory myocarditis in virus-challenged mice. Cellular immunity as assessed by cell-migration-inhibition resulted in specific cell-mediated sensitivity against anti-Ids (CVB3) as well as viral preparations. Animals pre-treated with anti-idiotypic preparations developed an anamnestic anti-viral antibody response, with antibodies capable of specifically binding CVB3 virus antigen in an ELISA assay; but without CVB3 viral neutralizing capability. Adoptive transfer of limited numbers of syngeneic anti-Id immunized lymphoid cell populations failed to alter the course of inflammatory myocarditis in CVB3 virus-challenged animals. Cellular binding studies utilizing anti-Ids suggested increased, but nonspecific binding of anti-Ids to lymphoid and myocyte populations in CVB3 infected animals. The data suggest an immunomodulatory role of idiotype-anti-idiotype interactions in the development of myocarditis.
Animals↗