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Biomedical subjects

R E Miller

Publications and source records attributed to R E Miller.

At least 271 records · Page 15Linked to original sources
PubMed1975

The cleansingenema.

Seventy-five per cent of carcinomas of the colon missed on radiologic examination were mistaken for or hidden by fecal material. Feces can alsomimic any lesion of the colon. A clean colon is essential for good diagnostic radiographs and adequate colonoscopic examination. The technique of administering a cleansing enema is described.

Barium Sulfate↗
PubMed1975

The effect of barium on blood in the gastrointestinal tract.

The effect of various commercial barium sulfate preparations on blood coagulation, flocculation, and hemolysis was studied. There was considerable variation not only among different barium products but also among different concentrations of the same product. There is no good experimental evidence that barium enemas do stop bleeding. It is probably best to avoid the use of any enema in attempting to control major colonic bleeding; but if an enema is given for this purpose, a tap-water enema is better, as it contains no anticoagulants and is more effective in producing clot formation than most barium suspensions.

Barium Sulfate↗
PubMed1975

The air-contrast stomach examination: an overview.

An overview of current air-contrast stomach examination techniques is offered: (a) Hampton's technique which does not use distension; (b) the Japanese method which utilizes the relaxant drug Buscopan, good distension, and much patient rotation; (c) a third method in which no drugs are used but more distension is obtained than in Hampton's technique; and (d) the Australian mode which features relaxant drugs, extra dense barium, and little patient rotation. Experimentation with various techniques using newwer materials recently available should result in earlier diagnosis and better patient care in carcinoma and other stomach diseases.

Humans↗
PubMed1975

Neural inhibition of insulin secretion from the isolated canine pancreas.

UNLABELLED: By using an isolated in situ, cross-perfused pancreas preparation, direct neural effects on the immunoreactive insulin secretion rate (ISR) were separated from blood-borne influences. Blood from a large, anesthetized "support" dog was perfused through the pancreas of a small, anesthetized "pancreas" dog. Both splanchnic nerves of the pancreas dog were cut above the diaphragm and stimulated simultaneously (10 Hz, 0.1-ms pulses, 5-15 mA) for three 10-min periods, twice before and once during a pancreatic arterial phentolamine infusion (10 or 20 mug/min). Splanchnic nerve section caused a transient increase whereas stimulation caused a decrease in ISR. Phentolamine infusion blocked this decrease. In control experiments, an epinephrine infusion (25 or 50 mug/kg per min) was made into the systemic circulation of the pancreas dog instead of the first and second neural stimulations. No decrease in ISR occurred. Later neural stimulation (in the absence of phentolamine) was accompanied by a decrease in the ISR in three of four dogs. CONCLUSIONS: the ISR can be inhibited by direct neural imput to the pancreas, and this inhibition is mediated by alpha-adrenergic receptors.

Adrenalectomy↗
PubMed1975

Quantitative determination of coumestrol in dried alfalfa and alfalfa leaf protein concentrates containing chlorophyll.

An improved analytical method for the determination of coumestrol in dried alfalfa and leaf protein concentrates is described. In this method, chlorophyll is removed from an alcohol extract prior to the paper chromatographic-fluorometric measurement of coumestrol. Ninety-eight per cent of the coumestrol added to alfalfa leaf protein concentrates is recovered by this method. This improved method gives replicate values with lower standard deviations and coefficients of variation than the literature method.

Animal Feed↗
PubMed1975

Response of normal subjects to a single 2-milligram dose of glucagon administered intramuscularly.

Recently there has been increased interest in glucagon because in human radiographic and endoscopic studies it has been reported to relax the gallbladder, stomach, small bowel and colon. These results suggest it may be preferable as a diagnostic aid for these procedures. Therefore, we believed it important to assess the safety, and clinical laboratory responses after glucagon is given to normal subjects. Twenty normal subjects received 2 mg of glucagon and placebo intramuscularly at daily intervals, double-blind and crossover. After glucagon there was an increase in the WBC, bands, neutrophiles, fasting blood sugar, glucagon and insulin, and a decrease in the lymphocytes. There was no change in the pulse rate or blood pressure with minimal reports of side effects. These results tend to confirm other reports that glucagon is one of the stress hormones. Glucagon is remarkably safe and produces few, mild and transient side effects, not much greater than placebo.

Adult↗
PubMed1975

[The complete colon examination (author's transl)].

The radiologist must assume complete responsibility for the preparation and examination of the entire colon including the rectum. He must cooperate with and constantly check his findings with the colonoscopist. When one considers the increasing patient load, we cannot expect that all radiologists will be willing or able to assume the additional effort to produce Welin's precise results routinely. However, even with these examiners, the air contrast method can still fulfill the role of a precise and ultimate examination, especially in certain selected high risk groups. What Dr. Leo Rigler has said about lung cancer also applies to tumors of the colon. No matter how great or sophisticated the mental ability and our tools in differential diagnosis, it is all in vain if we do not find the lesion. Not to find the lesion is the irrevocable error.

Adenocarcinoma↗
PubMed1974

Wisdom in a wager.

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Education, Medical, Graduate↗