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Biomedical subjects

R E Kaderly

Publications and source records attributed to R E Kaderly.

7 recordsLinked to original sources
PubMed1996

Carcinogenicity of CoCrMo (F-75) implants in the rat.

A long-term study was conducted in rats to assess the contribution of the surface area of CoCrMo devices to carcinogenesis. Groups consisting of 104 rats each (52 male, 52 female) were either implanted with metal cylinders fixed on the left, lateral femur (groups 1-3) or injected with a suspension of metal microspheres in the dorsal subcutis (group 4). Group 1 (control) received solid Ti6Al4V cylinders [surface area to body weight (SA/BW) ratio measuring 1.35 times that of human total hip prosthesis (HTHP)]. Group 2 was implanted with solid CoCrMo (SA/BW ratio: identical to implants of group 1). Group 3 received sintered-porous CoCrMo devices (SA/BW ratio: 30 x HTHP). Group 4 was injected with a suspension of CoCrMO microspheres (SA/BW ratio: 135 x HTHP). Implant-associated tumors (IATs) were observed in 23, 14, 3, and 15 rats of groups 1, 2, 3, and 4, respectively. Within groups 1 and 2, 34 IATs were associated with loose implants, three with undetermined implant fixation status, and none with fixed implants. A significantly increased accumulation of chronic inflammatory tissues around loose rather than fixed implants suggested a foreign-body reaction as the primary mechanism of carcinogenesis. A secondary role in carcinogenesis was ascribed to the increased CoCrMo implant SA/BW ratios as indicated by a 14.6% IAT incidence in group 4 versus 3% in group 3. These results support the notion that early intervention in the removal of loose metal devices is warranted to mitigate against foreign body-induced carcinogenesis, at least in this animal model.

Animals↗
PubMed1992

Diet and exercise as potential risk factors for osteochondritis dissecans in dogs.

A matched case-control study was conducted to evaluate dietary components and exercise patterns as potential risk factors for osteochondritis dissecans in dogs. A telephone interview, with a standard questionnaire and protocol, was used to collect data on dietary intake of calories and nutrients and on the usual amounts and types of exercise of each dog. Thirty-one dogs with osteochondritis dissecans and 60 controls were matched on the basis of breed, sex, and age. Using a conditional logistic regression model, high dietary calcium, playing with other dogs, and drinking well water (rather than city water) were associated with increased risk of osteochondritis dissecans. Feeding of specialty dry dog foods was associated with decreased risk.

Animal Nutritional Physiological Phenomena↗
PubMed1983

Intracapsular and intraosseous vascular supply to the mature dog's coxofemoral joint.

The intracapsular and intraosseous arterial supply to the mature dog's coxofemoral joint was investigated using a vascular injection, tissue-clearing technique in 6 mixed-breed dogs. Ascending arteries of the femoral neck, arising from an extracapsular vascular ring at the base of the femoral neck, penetrated the articular capsule and traveled subsynovially over the surface of the femoral neck. These intracapsular arteries formed an incomplete intracapsular vascular ring at the junction of the femoral head and neck. Bony components of the acetabulum, ie, ilium, ischium, and acetabular bones, received intraosseous vascular supply from the nutrient artery of the ilium and minute vessels entering nutrient foramina around the rim of the acetabulum. The femoral head received branches (epiphyseal arteries) from the ascending arteries of the femoral neck at the intracapsular vascular ring. Epiphyseal arteries formed anastomosing vascular arches of decreasing caliber up to the subchondral bone of the femoral head. The proximal femoral metaphysis, particularly the femoral neck, received vascular supply from 4 sources: (i) branches from the epiphyseal arteries on the surface of the physeal scar which descended, penetrating the physeal scar, (ii) distally directed branches from the intracapsular vascular ring, (iii) ascending nutrient vessels from the trochanteric fossa, and (iv) terminal branches of the ascending nutrient artery of the femur.

Acetabulum↗
PubMed1982

Extraosseous vascular supply to the mature dog's coxofemoral joint.

Blood vessels supplying the coxofemoral joint were identified and described in 8 healthy, mature dogs. An accurate representation of the blood vessels was obtained by intra-arterial methyl methacrylate injection and sodium hydroxide corrosion of soft tissues until only the pelvis, femurs, and casts of the blood vessels remained. The sources of vascular supply to the dog's coxofemoral joint, from most to least contributory, were the lateral circumflex femoral artery, the medial circumflex femoral artery, the caudal gluteal artery, the cranial gluteal artery, and the iliolumbar artery. In addition, important vascular relationships were demonstrated. Many blood vessels were associated with the periosteal surfaces of the coxofemoral joint in areas of muscular and articular capsular attachment; fewer vessels were present in areas of loose periosteal attachment. Also, extra-articular anastomoses were identified. The most significant anastomosis was an extracapsular vascular ring located at the femoral attachment of the articular capsule. The extracapsular vascular ring was formed by branches of the lateral and medial circumflex femoral and caudal gluteal arteries.

Animals↗
PubMedDate not supplied

Cranial approach to the humerus for repair of fractures in horses and cattle.

A cranial approach to the humerus was developed for application of a compression plate for repair of comminuted humeral fractures in a weanling foal, a calf, a heifer, and a mature cow. An incision was made from the cranial portion of the greater tubercle of the humerus to the radius. The cranial aspect of the humerus was exposed by retraction of the brachiocephalicus muscle and blunt dissection between the biceps brachii and brachialis muscles. A second plate was applied laterally in the heifer and cow by retraction of the brachialis muscle and elevation of the extensor carpi radialis muscle. Successful fracture reduction, alignment, and stabilization were achieved in all four animals.

Animals↗
PubMedDate not supplied

Stabilization of bilateral sacroiliac fracture-luxations in small animals with a single transsacral screw.

Bilateral sacroiliac fracture-luxations in four dogs and four cats weighing 3.5 kg to 30.9 kg were reduced and stabilized with a single 3.5 mm, 4.5 mm, or 6.5 mm transsacral screw. Alignment of the drill bit was visual in six cases and assisted by the use of an aiming device in two cases. Seven animals were reevaluated at months 3 to 6. No significant screw loosening or loss of reduction had occurred. Although no intraoperative complications were encountered with visual drill bit alignment, use of an aiming device for transsacral drilling is strongly recommended.

Animals↗