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Biomedical subjects

R E Henry

Publications and source records attributed to R E Henry.

33 records · Page 2Linked to original sources
PubMed1975

Further evaluation of 99m-Tc sulfur colloid accumulation in rejecting renal transplants in man and a canine model.

Renal transplant accumulation of 99m-Tc sulfur colloid was evaluated in 41 patients. Ninety-five examinations were performed comparing transplant with bone marrow activity and clinical or pathological diagnosis. 99m-Tc sulfur colloid accumulated in acute or chronic rejection as long as the vascular supply of the grafted kidney was not severely impaired. Accumulation was marked in chronic rejection, slight in acute rejection and absent in normally functioning transplants or in those with acute tubular necrosis. In the 10 dog models, no accumulation was seen in autografted transplants and early accumulation was demonstrated within the hyperacutely rejecting kidneys of allografted dogs.

Angiography↗
PubMed1975

Radioisotopic detection of osseius metastases. Evaluation of 99mTc polyphosphate and 99mTc pyrophosphate.

A total of 146 patients were investigated for the presence of osseous metastases with 99mTc polyphosphate or 99mTc pyrophosphate bone scans. Results of bone imaging were retrospectively compared to roentgenographic results surveying similar anatomic areas in 128 patients. This comparison revealed that roentgenographic interpretations were in error in 19% of the cases. Thirty-three patients had bone scans and roentgenograms that were in agreement and considered abnormal, but in more than one third of these cases the patients had multiple abnormalities that were shown by the bone scan but were not recognized roentgenographically. In consideration of the low toxicity, ready availability, economy, shortened procedure time, and low radiation dose associated with the use of these new bone-seeking agents, it is concluded that they are superior to roentgenograms and previously utilized radionuclides for early detection of osseous metastases.

Bone Neoplasms↗
PubMedDate not supplied

Bone marrow 99m Tc sulfur colloid distribution and marrow cellularity.

The relationship between marrow distribution as imaged with 99mTc sulfur colloid and histologic estimate of bone marrow cellularity was examined in 101 patients. The patients were divided into three groups according to marrow cellularity: normocellular, hypercellular or hypocellular marrow. The marrow distribution of these patients was graded as extended, not extended or not visualized. A general association between marrow cellularity and marrow distribution was found. Seventy-seven per cent of patients with normocellular marrow had limitation of marrow within normal sites and a similar number of patients with reactive hypercellular marrow had marrow extension. On analysis of the patients that were exceptions to this generalization the following observations were made. In patients in whom the marrow is hypercellular and infiltrated with abnormal cells or tissue the marrow distribution may not be visualized with radiocolloid. Stimulation of hematopoiesis may result in marrow hypercellularity without marrow extension beyond the usual sites. Stimulation of one or more hematopoietic cell lines may result in marrow extension without marrow hypercellularity, suggesting an impairment of hematopoietic cell response. Peripheral marrow extension as observed with radiocolloid, therefore, is not simply a reflection of marrow hypercellularity but probably represents a response of the bone marrow stroma to situations in which one or more hematopoietic cell lines is stimulated.

Adult↗
PubMedDate not supplied

Time-dependent localization of arsenic in subcellular liver fractions.

In an effort to assess previously reported localization of arsenic within the hepatocyte nucleus (determined on the basis of increases in the percent of nuclei containing inclusion structures as time of exposure to arsenic increased) (Sorensen, 1976c), cell separations were conducted on fish livers following in vivo exposures identical to those previously reported. Green sunfish were exposed to 60 ppm arsenic for 2, 4, or 6 days prior to homogenation and subfractionation of the liver for arsenic determinations by neutron activation analysis. Mean percent arsenic in the soluble cytoplasmic fraction decreased significantly from 46 to 28 to 17 percent in 2, 4, or 6 days, respectively; whereas arsenic in the nuclear and cell residue fraction increased significantly from 12 to 42 to 58 percent during the same time period. All subfractions were found to contain homogeneous populations of subcellular organelles.

Animals↗