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Biomedical subjects

R E Ferguson

Publications and source records attributed to R E Ferguson.

10 recordsLinked to original sources
PubMed2001

Biomechanical performance of new cardiovascular needles.

Cardiovascular needles are now being manufactured from new stainless steel alloys containing high concentrations of nickel, Surgalloy and Ethalloy. The purpose of this study was to compare the biomechanical performance of a cardiovascular needle made of Surgalloy with a comparably sized needle made of Ethalloy. The parameters of biomechanical performance included sharpness, maintenance of sharpness, resistance to bending, and ductility. Because the biomechanical performance of these needles was remarkably similar, cardiovascular needles made of either the Surgalloy or Ethalloy alloys are recommended for cardiovascular surgery.

Alloys↗
PubMed2001

Fibrin sealants in microvascular surgery: current status.

During the last two decades, advances in fibrin sealant formulation have resulted in its investigational and clinical use in various surgical endeavors, including microvascular surgery. Several investigations have comparatively evaluated fibrin adhesive-enhanced microvascular anastomoses vs. conventional suture repair. The purpose of this review is to summarize the collective documentation on fibrin adhesives in microvascular surgery on the basis of the scientific performance parameters of vessel patency, bursting strength, anastomotic competence, and reendothelialization. In addition, other applications of fibrin sealants and other qualities unique to fibrin adhesives are addressed.

Animals↗
PubMed1999

Dynamic measurement of myosin light-chain-domain tilt and twist in muscle contraction.

A new method is described for measuring motions of protein domains in their native environment on the physiological timescale. Pairs of cysteines are introduced into the domain at sites chosen from its static structure and are crosslinked by a bifunctional rhodamine. Domain orientation in a reconstituted macromolecular complex is determined by combining fluorescence polarization data from a small number of such labelled cysteine pairs. This approach bridges the gap between in vitro studies of protein structure and cellular studies of protein function and is used here to measure the tilt and twist of the myosin light-chain domain with respect to actin filaments in single muscle cells. The results reveal the structural basis for the lever-arm action of the light-chain domain of the myosin motor during force generation in muscle.

Animals↗
PubMed1999

Innovative techniques in arthroscopic meniscal repair.

Advanced techniques for arthroscopic repair of meniscal tears offer new ways to repair the meniscus and reduce the rate of long-term arthrosis. The new all-inside technique reduces complications, morbidity, and surgical time as compared to the inside-out or outside-in methods of repair. Application of biomaterial technology to new implants used for all-inside arthroscopy show early promising clinical results. The purpose of this report is to describe new biomaterials and techniques being used successfully in arthroscopic surgery on the meniscus.

Arthroscopy↗
PubMed1999

Modern concepts in arthroscopic Bankart repair.

The purpose of this report is to review recent advances in Bankart repair that allow it to be performed arthroscopically. Metallic implants in the form of staples, screws, or rivets were used initially, but problems with loosening of implants has prompted development of alternative devices and techniques. A modified form of the transglenoid suturing technique used in open Bankart repair has been used successfully but is associated with an increased risk of soft tissue complications. The use of absorbable tacks avoids some of the complications associated with this approach, but the ability to advance the capsule to reduce the volume is limited. Recently, the use of suture anchors has been described for arthroscopic Bankart lesion repair. However, the ability of these anchoring systems to advance and reduce the capsular volume is limited, and the arthroscopic techniques are technically demanding. One particularly innovative suture anchor system uses a bioabsorbable suture anchor with an integrated suture passing system. This self-contained implant allows multiple passes with suture through the capsule, followed by attachment to the glenoid with the bioabsorbable anchor. This procedure allows the capsule to be advanced by passing suture through before it is anchored to the glenoid, thereby reducing capsular volume to help restore shoulder stability.

Arthroscopy↗
PubMed1991

The Lang strain of reovirus serotype 1 and the Dearing strain of reovirus serotype 3 differ in their sensitivities to beta interferon.

Replication of the Dearing strain of reovirus serotype 3 in mouse L cells was decreased 17- to 100-fold when a saturating dose of beta interferon (1,000 IU/ml) was used. Replication of the Lang strain of reovirus serotype 1 was inhibited only two- to threefold under similar conditions. It therefore appears that closely related strains of reovirus differ in their sensitivities to beta interferon treatment of mouse L cells.

Animals↗
PubMed1979

Domesticated doctors.

Explore the source record for details and available documents.

Education, Medical, Continuing↗
PubMed1979

Domesticated doctors.

Explore the source record for details and available documents.

Education, Medical, Continuing↗