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Biomedical subjects

R E Domen

Publications and source records attributed to R E Domen.

51 records · Page 3Linked to original sources
PubMed1988

Red cell alloimmunization in chronic renal failure patients undergoing hemodialysis.

Posttransfusion alloimmunization to red cell antigens was studied in a group of 98 chronic renal disease patients treated solely with hemodialysis. Clinically significant red cell antibodies were formed in only 6.1% of transfused patients, and only 1 patient formed more than one antibody. We do not recommend extended red cell phenotyping, beyond ABO and Rh(D), in patients with end-stage renal disease who may require transfusion.

Adult↗
PubMed1986

Efficacy of performing red-cell antibody elutions in patients with a positive direct antiglobulin test.

Red blood cell antibody elutions are often routinely performed whenever a positive direct antiglobulin test (DAT) is encountered. To evaluate the efficacy of performing routine red-cell elutions we reviewed our antibody elution data. Of 122 eluates, 83 were negative, 35 were warm panagglutinins, 2 were felt to be transfusion-induced alloantibodies, 1 was passively acquired anti-A, and 1 was inconclusive. One of the eluted alloantibodies was not demonstrable in the serum. Thus, only 1 (0.8%) of the eluates provided important information not readily available through serum testing alone. We conclude that extensive serologic evaluation of a positive DAT should be reserved for those patients who have been recently transfused or are suspected of having immune hemolysis.

Agglutinins↗
PubMed1986

Coagulation and immunology.

One of the most vital functions of the vertebrates is to maintain hemostasis through coagulation and fibrinolysis. This is achieved by the interaction of vascular walls with blood components such as cells and proteins (coagulation factors, immunoglobulins, and complement). Deficiency of coagulation factors results in bleeding disorders. The immune system, in response to foreign proteins or defective self proteins, produces antibodies triggering an Ag-Ab interaction with the related host of different reactions including abnormal coagulation leading to hemorrhagic diathesis.

Antigen-Antibody Complex↗
PubMed1984

Changes in calcium distribution during therapeutic plasmapheresis.

Observations of normal persons indicated that there was a net shift of serum calcium from the ionized and protein-bound fractions to the anion-bound fraction when these persons received citrate during donor plasmapheresis. To confirm these findings and to extend them to diseased persons, we measured total, ionized, and ultrafilterable Ca concentrations in 11 patients who were undergoing therapeutic plasmapheresis. Anticoagulation was achieved with anticoagulant citrate dextrose solution. Mean concentrations of total, ionized, and protein-bound Ca decreased, whereas the ultrafilterable and anion-bound fractions increased. Our results suggest that protein-bound Ca may be relatively labile and may help to maintain constant levels of ionized Ca. Also, the observed increase in the anion-bound Ca level with citrate infusion suggests a shift from the protein-bound and ionized Ca fractions to this pool.

Adult↗
PubMed1983

Therapeutic apheresis. Applications and future directions.

The past 10-15 years have been witness to major technological achievements in the field of therapeutic apheresis. Concurrently, a large number of diseases, primarily with an immunological basis, have been treated with apheresis. In this paper, we review the various applications of therapeutic apheresis, adverse reactions associated with the mode of therapy, and future research directions. Several representative diseases are also discussed in detail.

Antigen-Antibody Complex↗
PubMed1981

Lithium carbonate.

Explore the source record for details and available documents.

Bipolar Disorder↗
PubMed1980

The glucagonoma syndrome. Report of a case.

A 73-year-old man had diabetes mellitus, diarrhea, weight loss, and a rash of several years' duration. The rash, termed necrolytic migratory erythema, was the most characteristic feature and eventually suggested the diagnosis of a glucagon-secreting tumor of the pancreas. Diabetic ketoacidosis also developed in our patient, a previously unrecognized occurrence with this syndrome.

Adenoma, Islet Cell↗
PubMed1979

Granular cell myoblastoma of the esophagus after irradiation for carcinoma.

Granular cell myoblastoma is an uncommon, usually benign tumor. Only 20 cases are reported in the esophagus. We describe a 65-year-old woman who developed a granular cell myoblastoma of the postericoid esophagus in the area of a squamous cell carcinoma successfully treated with irradiation. To our knowledge, this is the 21st reported case, and the only case occurring in the esophagus after irradiation for primary squamous cell carcinoma.

Aged↗
PubMedDate not supplied

Hemostatic imbalances produced by plasma exchange.

Ten patients who underwent intensive therapeutic plasma exchange were studied prospectively to determine the nature and extent of changes induced in their coagulation mechanisms. The patients' plasma was replaced with serum albumin and normal saline. Significant changes were noted acutely in the prothrombin time, activated partial thromboplastin time, plasma fibrinogen, and platelet counts. Chronically, significant decreases were found in plasma fibrinogen concentrations and platelet counts. Intensive plasma exchange with fluids devoid of coagulation factors results in defects in the normal hemostatic mechanism.

Adult↗