Biomedical subjects

R E Dionne

Publications and source records attributed to R E Dionne.

2 recordsLinked to original sources

PubMed1983

Pirprofen.

Pirprofen, a nonsteroidal antiinflammatory drug (NSAID) undergoing Phase III investigation as Rengasil (Ciba-Geigy Corp.), is useful in the management of both rheumatoid arthritis and osteoarthritis and as an analgesic. In doses of 600-800 mg/d, pirprofen has been found to be as effective as, but not superior to, aspirin 3.6 g/d in relieving the more common symptoms of rheumatoid arthritis. Pirprofen is as effective as, but not superior to, other available NSAIDs in terms of efficacy, tolerability, and incidence of adverse effects. The recommended dosage in osteoarthritis is 450-600 mg/d. As with all NSAIDs, including aspirin, the side effects most commonly seen with pirprofen are gastrointestinal in nature. Peptic ulceration and occult gastrointestinal blood loss have been reported in a small percentage of patients receiving pirprofen. Central-nervous-system-related side effects that are frequently associated with high-dose aspirin therapy appear less frequently with pirprofen. Although it does not offer distinct advantages over other NSAIDs, pirprofen offers an effective therapeutic alternative for patients who are unable to tolerate aspirin or other existing compounds.

Animals↗

PubMed1981

Estimating creatinine clearance in morbidity obese patients.

Estimates of creatinine clearance (Clcr), using five methods, were compared to measured Clcr in morbidity obese patients. Patients whose total body weight (TBW) was greater than or equal to 195% of their ideal body weight (IBW) and who had urinary Clcr measured with 24-hour urine collections were studied. The 12 men weighed an average of 180 kg; the 31 women averaged 138 kg. The methods studied considered a combination of the following factors: weight, age, sex, and serum creatinine. One method was a nomogram; TBW could not be used because of limitations of the nomogram. Both TBW and IBW were used in two methods that considered weight as a variable. Measured Clcr averaged 105.7 ml/min/1.73 sq m body surface area. All estimating methods using IBW significantly underestimated Clcr; all methods using TBW significantly overestimated Clcr. Two methods that did not include body weight as a variable predicted Clcr more accurately than did other methods, but there was still a significant difference between estimated and measured Clcr. None of the Clcr estimation methods is accurate in morbidly obese patients.

Adult↗