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Biomedical subjects

R E Arnold

Publications and source records attributed to R E Arnold.

10 recordsLinked to original sources

A descriptive experience of total thyroidectomy as the initial operation for differentiated carcinoma of the thyroid.

Sixty-five patients with differentiated carcinoma of the thyroid gland were registered with the tumor registry of Camp Lejeune Naval Hospital. There were no death attributed to thyroid carcinoma. A vigorous follow-up program was followed, and 11 recurrences were diagnosed and treated. Recurrences were considered treatment failures. The recurrence rate for total thyroidectomy patients was much lower than for any other operation. Many investigators, including those of two current surgery textbooks, have acknowledged that total thyroidectomy is superior for control of the disease but have been reluctant to recommend it because the complications are presumed to be too numerous. The results of this analysis rebut that presumption. The operating surgeons are not thyroid experts, yet their results were excellent. It is reasonable to assume that a trained general surgeon is capable of performing a total thyroidectomy without an unacceptable high incidence of postoperative complications.

Adenocarcinoma

Transcription of a yeast ribosomal RNA minigene in Saccharomyces cerevisiae.

A transcription system using intact yeast has been developed for investigating which sequences are implicated in the initiation of transcription of yeast rRNA genes. The system employs an rRNA minigene that consists of the initiation and termination sites for rRNA biosynthesis separated by approx. 700 base pairs of vector DNA in the Escherichia coli-yeast shuttle vector, pJDB207. Two recombinants containing this minigene were constructed; one retained all of the nontranscribed spacer DNA upstream from the initiation site, the other retained 208 base pairs of this DNA. Transcripts of this structurally unique minigene in RNA from yeast transformed with these recombinants were readily detected by nuclease S1 mapping. These transcripts were initiated at the site used by the host rRNA genes, were approx. 3-fold more abundant in the recombinant retaining all of the nontranscribed spacer and were less abundant when the yeast was not growing.

Endonucleases

Controversies and hazards in the treatment of pit viper bites.

This paper discusses the pathology produced by pit viper venom and the pharmacologically active substances released by the action of venom on human tissue. The risks of many of the popular methods of treatment such as tourniquets, cryotherapy, incisions, excisions, and cortisone are also discussed. A prospective treatment plan was devised which was limited to measures of proven benefit, and 28 patients were treated with no mortality or tissue necrosis.

Adolescent

Brown recluse spider bites: five cases with a review of the literature.

Brown recluse spider bites can cause ulcerations of the skin, intravascular hemolysis and death. Five clinical cases are presented with a summary of known pathological processes, clinical findings, and recommended methods of treatment. The possibility of systemic manifestation make the physician's knowledge of loxoscelism, early diagnosis and adequate treatment necessary.

Adolescent

Spontaneous rupture of the spleen with EMATOMA.

A case of spontaneous rupture of the spleen with hematoma is presented. The spleen presumably with ruptured while the patient was in the hospital, during a severe coughing episode secondary to viral pneumonia. The time interval between splenic rupture and operation was 31 days. Along with pertinent diagnostic acids, difficulty in making the diagnosis is stressed. Knowledge that this condition exists is a major factor in making the diagnosis.

Adult

Snake bite.

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Animals