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Biomedical subjects

R During

Publications and source records attributed to R During.

At least 55 records · Page 3Linked to original sources

[A case of severe superimposed toxaemia of pregnancy accompanied by coagulopathy (author's transl)].

Reported in this paper is a case of severe superimposed toxaemia of pregnancy with concomitant coagulopathy. Heparin, fresh blood, PPSB, and cryoprecipitates were used for the treatment of the coagulopathy. Hypertension was brought under control, but the general condition of the patient deteriorated for uncontrollability of the coagulopathy. Therefore, caesarean section was applied in the 31st week of pregnancy, before coagulation normalised and the patient's general condition improved.

Adult↗

[Localisation of placenta by liquid crystal thermography (author's transl)].

The efficiency of liquid crystals in placenta localisation was checked by comparison of thermographic results with those obtained from using the ultrasonic B-scan method. Ther results obtained from the two techniques were in fair agreement in 93 of 106 cases or 87.7 per cent. The highest amount of agreement was recorded from the group with anterior-wall placenta. For placenta localisation the sensitivity of liquid crystal thermography was found to be inferior to that of the ultrasonic B-scan method.

Female↗

[Dilatol for hypertension therapy in pregnancy (author's transl)].

Dilatol (Nylidrin), a betamimetic used for tocolysis, was applied to ten hypertensive women in advanced pregnancy and produced in them characteristic effects with favourable impact upon oxygen supply to the foetuses, such as significant lowering of diastolic pressure, decrease in total peripheral resistance which reflected increase in uteroplacental blood flow, as well as rises in heart rate, stroke volume, and cardiac output. Nylidrin, therefore, may be recommended as a hypotensive drug in the treatment of arterial hypertension in pregnancy.

Adult↗

[Determination of selected coagulation parameters in induced abortion by means of 15-methyl-PGF2 alpha].

There were accomplished investigations about changes of bleeding and recalcification time, platelet count, levels of heat-fibrin, prothrombin, partial thromboplastin time, platelet adhesiveness and heparinocytes at 10 women during induction of therapeutic abortion by use of intramuscular injections of 15-methyl-PGF2 alpha in the first and second trimester of pregnancy. The studies were performed before treatment, 30 minutes, 4 and 8 hours after beginning 15-methyl-PGF2 alpha-administration, 2 hours after expulsion of product of conception and 24 hours after first injection. The following investigations showed statistical significant changes: Prothrombin decreased during treatment with 15-methyl-PGF2 alpha and did not obtain the starting value 24 hours after first injection. Platelet count showed an equal attitude. The heparinocytes showed a continuous falling off up to 2 hours after termination the pregnancy. A significant ascent was noticed 24 hours after first investigation. The results of studies did not indicate a strong injury of coagulation system. They support the positive estimate for induction of therapeutic abortion with 15-methyl-PGF2 alpha in the first and second trimester of pregnancy.

Abortion, Induced↗

[Amniocentesis with free needle guidance following pinpointing using ultrasonic compound scan].

There is reported about 106 amniocenteses between 28th and 40th week of pregnancy after previous investigation and marking of the point of puncture on the abdomen of the pregnant woman by means of investigation the point with ultrasonic compoundscan. The angle of puncture method is found out and the maximum and minimum infiltration intensity. Complications have not been observed. That technique makes possible a high security for puncture and excellent puncture results.

Amniocentesis↗

[Pros and cons in the therapy of hypertensive gestoses. I. Pre-eclampsia and eclampsia].

The authors report on the modern trends and the pro and contra in treatment of pre-eclampsia and eclampsia. Ambulatory therapy is only allowed in mild preeclampsia by rest, high-protein lowcaloric diet and mild sedation. Also during the stationary therapy diuretics should be commonly avoided. As sedative drugs magnesium sulfate, diazepam, clomethiazole and barbiturates are recommended. Antihypertensive drugs are given when the blood pressure exceeds 180/110 mm Hg. Favoured drugs are hydralazine, methyldopa and beta adrenergic substances. For the treatment of eclampsia well tried standardized methods with few drugs as magnesium sulfate and when necessary barbiturates and hydralazine are mentioned, furthermore, the combination with new therapeutic managements as the osmo onco-therapy and the modern anaesthetic technics. There is agreement that in severe preeclampsia induction of labor should be performed before term. The indication for that is facilitated by the modern perinatal diagnostics.

Antihypertensive Agents↗

[Bacteriological studies of the human amniotic fluid in repeated amniocenteses].

The amniocentesis to gain increasing importance ought to be examined whether an alteration of the bacterial flora of the amniotic fluid was caused by repeated amniocentesis. 128 samples of amniotic fluid selected by abdominal amniocentesis were placed in microbiological cultures. Bacteria was isolated in 30 cases, originated predominantly by pollution. Under the circumstance of strong sterile conditions the amniocentesis proven even when repeated a diagnostical way of procedure which does not represent any danger to mother nor child.

Amniocentesis↗

[Studies on the binding capacity of thyroxin-binding globulin (TBC), total thyroxin (T4), free thyroxin index (FT4-I) and the ETR-test in gestosis and placental insufficiency].

Total serum thyroxine (T4), thyroxine binding capacity (TBC), free thyroxine index (FT4-I) and effective thyroxine ratio (ETR) were measured in 53 toxemias of pregnancy and in 5 cases with placental insufficiency. Total serum thyroxine, ETR and FT4-I were found in physiological ranges of the normal pregnancy, the TBC-index was decreased. Between the 19. and 34. week of pregnancy, the decrease of the TBC-index was smaller than after the 34. week of pregnancy.

Adult↗

[Blood coagulation studies of therapeutic abortion induced by 15-methyl-prostaglandin F2 alpha].

10 women with unwanted pregnancies in the first and second trimester were terminated by use of intramuscular injections of 15-Methyl-PGF2alpha. Studies of bleeding and recalcification time, platelet count, levels of heat-fibrin, prothrombin, partial thromboplastin time, platelet adhesiveness and heparinocytes were performed before treatment. 30 minutes, 4 and 8 hours after beginning of 15-Methyl-PGF2alpha-administration, 2 hours after the expulsion of the product of conception and 24 hours after first investigation. Prothrombin decreased during treatment with 15-Methyl-PGF2alpha and did not obtain the starting value 24 hours after first investigation. Platelet count showed an equal attitude. The time of recalcification increased continuous. Heparinocytes continuous decreased up to 2 hours after expulsion of the product of conception. 24 hours after first investigation a significant ascent was noticed. The results of the studies on coagulation did not indicate a strong injury of coagulation system. They suggest the positive estimation of termination of pregnancy in the first and second trimester with 15-Methyl-PGF2alpha.

Abortion, Missed↗

[A critical review of hypothetical causes of EPH-gestosis].

The essential EPH-gestosis seems to have multiple aetiological factors and the disease develops already a long time before the appearance of the classical symptoms. The disturbed renal function is the main point among secondary pathological effects as the damaged placenta, the disseminated coagulation, the glomerular endotheliosis, the increased retention of water and sodium with increased arterial responsiveness. It may be that this reduced reversible renal function is of extra-renal origin. As predisposing factors were discussed the reduced uteroplacental circulation with the release of still unknown pressor substances or decreased inactivation of pressor amines, the uterorenal reflex mechanism, the disturbed homeostasis of the body fluids and the vegetativ-hypothalamic crisis etc. But other factors may also be participate on this disease as immunological and hormonal aspects, especially the renin-angiotensin-aldosteron-system and prostaglandins. To find out the aetiological factors we should examine the disease at the beginning in comparison with normal pregnancy. These factors must explain why the true EPH-gestosis appears mainly during the first pregnancy and frequently in twins and so on.

Aldosterone↗