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Biomedical subjects

R Dumas

Publications and source records attributed to R Dumas.

At least 325 records · Page 18Linked to original sources
PubMed1979

Dialysis bone disease in childhood: treatment with 25-hydroxycholecalciferol.

The effect of 8 months of administration of moderate doses of 25-hydroxycholecalciferol (25 OH D3) on radiologic, biologic, and bone histologic changes was assessed in five children on chronic hemodialysis. Osteomalacia, defined by an increase in the thickness index of the osteoid seams and decrease of the calcification rate, was present on the initial bone biopsy of only one patient and improved with the treatment. Secondary hyperparathyroidism and its prints on bone tissue, noted in all five children, did not improve in the absence of adequate serum phosphorus control. Furthermore, cancellous bone volume diminished in two patients with the administration of 25 OH D3. This activity of the drug could be related to its inhibitory effect of osteoblastic apposition as demonstrated by the decrease in the calcification rates, while the thickness index of the osteoid seams remains normal. Despite the small number of patients studied, these results suggest the importance of limiting the prescription of 25 OH D3 to children suffering from renal osteodystrophy only after having assessed unequivocally an osteomalacic component by histodynamical criteria. Secondary hyperparathyroidism appears not to be improved with moderate doses of 25 OH D3 in the absence of adequate serum phosphorus control.

Adolescent↗
PubMed1979

[Cardiological aspect of Kearns' syndrome. Apropos of 3 cases, with histopathological study of the conduction tissue in one of them].

Three cases of Kearns syndrome are reported. The neuro-ophthalmological signs were comparable with ophthalmoplegia, pigmentary retinal degeneration and polymorphic neuro-muscular and sensory deficits. The electrocardiological signs were observed 2-4 years after the onset of the condition; the cause of death in each case was related to complete heart block. The post-mortem findings in one of the cases were spongial degeneration of the central nervous system and a seemingly primitive degeneration of the Bundle of His and its branches.

Adolescent↗
PubMed1979

[Study of the renin-angiotensin system in 2 cases of Wilm's tumor with severe arterial hypertension].

Two children who presented with Wilm's tumour and severe hypertension are described. The hypertension, which was secondary to excessive renin secretion, regressed after unilateral nephrectomy. In one child the total quantity of renin in the tumour was high and the peripheral plasma renin was also increased. The latter was unaffected by posture or a low salt diet and on angiography there was no compression of the renal arteries. Electron microscopy of the tumour cells showed numerous intra-cytoplasmic granules. In the other child the peripheral renin was only moderated elevated and could be stimulated by changes in posture or a low salt diet. Angiography demonstrated a large tumour that was compressing the renal artery on that side. No renin was detected in the tumour. In this child the inappropriate secretion of renin was probably due to renal parenchyma close to the tumour causing reno-vascular hypertension. The anti-hypertensive effect of propranolol given pre-operatively was excellent.

Antihypertensive Agents↗
PubMed1979

[Calcium and phosphrous evaluation during cortisone treatment of nephrotic syndrome in relapse].

Metabolic balances were used to study the intestinal absorption of calcium, magnesium and phosphate in children with steroid sensitive nephrotic syndrome in relapse. Magnesium balance was unaffected by the illness, steroid therapy, or by the addition of vitamin D. In contrast, the absorption of calcium and phosphorus was reduced by the illness and was still furthur diminished by the steroid therapy. The addition of vitamin D was totally ineffective in the doses used. The causes of these changes are discussed.

Calcium↗
PubMed1977

[Renal osteodystrophy in childhood. Comparison of histological and radiological findings (author's transl)].

We have examined radiologically the bones of seven children attained by renal osteodystrophy. A final score was established by syndrom: hyperparathyroidy, osteomalacia. The results are been confronted to the histomorphometrics studies. Numerous historadiological discordances appears: false radiologic findings 2/7, quantitative discordance of the lesions. Several conventional roentgenologic signs must be revalued after the priliminary histologic findings: cortical index, bone texture: osteomalacia, osteoporosis.

Adolescent↗
PubMed1976

Position reversal deficit in young ferrets.

Young ferrets (6 and 10 weeks old at the start of the experiments) were compared to adult ferrets on learning (1) a Lashley III maze, (2) a left-right discrimination in T-maze with identical choice arms, and (3) a reversal of the left-right discrimination. The young were not inferior to the adults in learning either the Lashley III maze or the initial discrimination in the T-maze. However, the young were markedly (and significantly) inferior to the adults in learning to reverse.

Age Factors↗
PubMed1976

[Neurological manifestations in monoclonal gammapathies. Pure neurological manifestations. Immunofluorescence study].

Analysis of 105 peripheral and central nervous system complications in 1062 monoclonal gammapathies draws attention to two types of phenomena. The possibility of pure neurological manifestations of IgM monoclonal gammapathies with macroglobulinorachia leads to discussion of their nosological position in relation to Waldenström's disease, Burkitt's lymphoma and Marek's disease. It is suggested that these cases should be reclassified under the heading "secreting neurolymphomatosis". Immunofluorescence and electron microscopy of 10 biopsies of the peripheral nerve showed deposits of monoclonal immunoglobulin whose function in determining peripheral neuropathies is discussed. The simultaneous presence of lymphoid infiltration, amyloid deposits and the monoclonal immunoglobulin (M component) suggests that this immunoglobulin could be the link between the cellular infiltrate secreting it and amyloid infiltration which would be the visible manifestation of it.

Amyotrophic Lateral Sclerosis↗
PubMed1976

[Membranoproliferative glomerulonephritis and mycoplasma infection].

Two children presented with an acute mycoplasma infection associated with a significant increase of antistreptolysin level. A severe nephropathy occurred, rapidly resulting in renal failure with histologic lesions of membrano-proliferative glomerulonephritis. Both patients had persisting low complement levels with low C3 and normal C4. The relationship between mycoplasma and streptococcal infections and the abnormality of complement and the renal disease is discussed.

Antistreptolysin↗
PubMed1975

[Relapsing parotitis: onset of Sjögren's syndrome].

Report of a case of lymphocytic parotitis associated with important inflammatory syndrome, anti-salivary antibodies and rheumatoid factor. The study of the cases of literature suggests that it might be the mode of onset of a Sjögren's syndrome.

Antibody Formation↗
PubMed1975

[Schwart-Jampel osteo-chondro-muscular dystrophy. 2 familial cases].

A complex syndrome was observed in two sisters. It associated important and dysharmonious dwarfism, craniofacial dysmorphy (blepharophimosis and microstomy), osteo-chondro dystrophy (vertebral column, pelvis, coxofemoral joints), oligophrenia and a muscular syndrome of myotonic type. The myotonic muscular syndrome is characterized by the prevalence at the face. Clinical and electric myotonia is clear. Voluntary muscular contractions induce prolonged myotonic responses. However there is no basal activity as observed in other cases. Curarization does not induce any disappearance of myotonic discharges. No specific histological change was shown: Schwartz-Jampel's muscular syndrome is not univocal; however it seems to depend on an abnormality of neuro-muscular activity, at the level of the end plate.

Adolescent↗