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Biomedical subjects

R Du

Publications and source records attributed to R Du.

70 records · Page 4Linked to original sources
PubMed1994

Distribution of red cell blood group systems in Achang and De'ang ethnic groups in China.

A survey on the distribution of red cell group systems, including ABO, MNSs, Rhesus and P, was carried out in the Achang and De'ang ethnic groups in Yunnan Province, South-West China. The Achangs are characterized by the highest frequency of IA in China, while the De'angs show a high frequency of IO and CDe. The distribution of these blood group systems in Achang and De'ang exhibits the same characteristics observed in other ethnic groups of South China.

ABO Blood-Group System↗
PubMed1992

[Studies of distribution of subtypes of transferrin, group-specific component, alpha 1-antitrypsin in gastric cancer patients from Shanghai area].

The genetic polymorphism of transferrin (Tf) and alpha 1-Antitrypsin (alpha 1-AT) in 202 gastric cancer patients and 202 controls in Shanghai Hans were analyzed by isoelectric focusing. In transferrin, the phenotype frequency of C1C1 and gene frequencies of c1 and c2 were 0.3713, 0.5718 and 0.4109 respectively in gastric cancer patients, and 0.5149, 0.6782 and 0.2970 separately in controls. The frequencies of the c1c1 phenotype and the C1 gene increased significantly (p < 0.01) among the controls, while the frequency of the C2 gene greatly increased (p < 0.01) among the patients. The frequencies of the C2C2 in gastric cancer patients and controls were 0.2228 and 0.1436 respectively, showing a significant difference between them (p < 0.05). The genetic polymorphisms of group-specific component (Gc) in 200 gastric cancer patients and 200 controls in Shanghai Hans were studied with isoelectric focusing followed by immunofixation. The Gc1F1F phenotype frequency and 1Fgene frequency were 0.22 and 0.4375 in gastric cancer patients, and 0.14 and 0.3600 in controls, respectively. The frequencies of the Gc1F1F phenotype and the 1F gene were significantly increased (p < 0.05) among the patients. In alpha 1-Antitrypsin, there was no significant difference in phenotype frequencies and gene frequencies between the patients and controls. The data reported here indicate that the gastric cancer is associated positively with TfC2 and Gc1F, and negatively with TfC1. These facts support the notion that cancerogenesis is a multi-step process controlled by multifactorial inheritance.

Adult↗
PubMed1992

[Genetic polymorphism of complement component six (C6) in five Han subpopulations].

By using polyacrylamide gel isoelectric focusing followed by immunoassay, the polymorphism of Complement Component Six (C6) was investigated in five Han subpopulations in China. The following gene frequencies were obtained Zhengzhou Han: C6*A 0.4521, C6*B 0.5228, C 6*B2 0.0183, C6*R 0.0068; Lanzhou Han: C6*A 0.4612, C6*B 0.5218, C6*B2 0.0170; Huhhot Han: C6*A 0.4452, C6*B 0.5286, C6*B2 0.0214, C6*R 0.0048; Xi'an Han: C6*A 0.4899, C6*B 0.4874, C6*B2 0.0126, C6*R 0.0101; Hakka of Meizhou, Guangdong Province: C6*A 0.4569, C6*B 0.5152, C6*B 0.0279 (C6*R is the frequency of rare alleles).

China↗
PubMed1990

Association of imperforate anus with short colon: a report of eight cases.

Eight cases of imperforate anus with short colon were seen in our hospital from April 1982 to December 1987. Five were boys, three were girls, and their ages ranged from 2 days to 2 years. The international literature about this kind of disease was reviewed. The disease's name, embryology, diagnoses, differential diagnosis, treatment, and prognosis are discussed herein. We suggest that this case, which was not combined with exstrophy of the bladder and/or intestine, be called association of imperforate anus with short colon (AIASC). Other cases, combined with exstrophy of the bladder and/or intestine could be called, association of imperforate anus with exstrophy splanchnica (AIAES). This distinction is necessary because each group differs in symptoms, signs, diagnosis, treatment, and prognosis.

Anal Canal↗
PubMed1990

[Distribution of 8 blood group systems in Han ethnic group of Fujian Province, China].

The distribution of 19 red cell's antigens of 8 blood group systems in Han ethnic group in Fujian province, China was investigated. The gene and haloptype frequencies were as follows: p = 0.1936, q = 0.1766, r = 0.6298; p1 = 0.1427; Dia = 0.2830; m = 0.5695, n = 0.4305, S = 0.0339, s = 0.9661, MS = 0.0200, NS = 0.0139, Ms = 0.5500, Ns = 0.4161; Fya = 0.8817; Jka = 0.4767; D = 0.9314, C = 0.7617, E = 0.2357, r' = 0.0686, R1 = 0.6352, R2 = 0.1970, R0 = 0.0605, Rz = 0.0388. Le (a +) phenotype frequency = 7.94%.

Blood Group Antigens↗
PubMed1990

[Genetic differentiation of red cell blood groups in fourteen populations of China].

Genetic differentiation among ethnic groups of China is analysed and discussed on the basis of gene frequency data of red cell blood groups. The degree of differentiation, measured by FST analysis of Wright, shows that the MNs system has much higher FST values than those of ABO system. This result is quite different from that calculated by Cavalli-Sforza (1966) on a worldwide basis. Generally speaking, the Rhesus, Lewis and MNSs systems are more useful in anthrological and human genetic studies on Chinese populations for they have a great variation. The genetic difference within and between 12 ethnic groups, namely, Han, Hui, Mongolian, Uygur, Zhuang, Yi, Korean, Manzu, Bai, Tibetan, Dong and Gaoshan, are also analysed. On the basis of gene frequencies of 15 blood group loci which are all polymorphic at least in one of 12 above-mentioned ethnic groups, the net coden difference between populations is calculated by method of Nei and Roychoudhury (1974), and phylogenetic dendrograms are constructed on the basis of net coden differences. Results obtained with the method of gene differentiation coefficient of Nei (1973) and that of Shannon information measure of Lewontin (1972), indicate that the genetic difference between ethnic groups of China accounts for only about 2% of the total genetic variation and is much smaller than that within ethnic groups. Genetic difference between three races of human being is also discussed by taking the Han living in northern China, as typical Mongoloids. On the basis of analysis of gene frequency data of 15 blood group loci, it is concluded that Mongoloids are genetically closer to black people than to white people.

Blood Group Antigens↗
PubMed1987

Distribution of red cell blood group systems in Yi, Tibetan and Manchu ethnic groups in China.

A survey on distribution of ten red cell blood group systems was carried out in 1985 in the Yi, Tibetan and Manchu nationalities in China. Significant differences were found in the distribution of Rh, MNSs, P and especially in the ABO system, while no significant difference was found for Diego, Duffy, Kell, Kidd and XG systems. The DI*a gene frequency was about 0.03, FY*a rather high (0.94), KEL*K extremely low (0.005) and JK*a was about 0.4. In the three nationalities under study, Yi is characterized by high frequencies of the alleles A, M and CDe and by the absence of CDE and Cde. Tibetans show a high frequency of O and a relatively high frequency of P*P1, while Manchus have the lowest frequency of M and in particular of MS.

Alleles↗
PubMed1987

Distribution of red cell blood group systems in Bai and Hani in China.

Two ethnic groups, Bai and Hani from Yunnan Province, South-West China, were examined for red cell blood group systems, including ABO, MNSs, Rhesus, Duffy, P, Diego, XG and Lewis. The samples, 200 for Bais and 212 for Hanis, were obtained from Jianchuan County and from Yuanjiang County respectively.

ABO Blood-Group System↗
PubMedDate not supplied

Distribution of PGM1 subtypes in 12 populations of China.

The distribution of PGM1 subtypes in 12 populations of China was studied by using isoelectric focusing (IEF) in 0.5 mm thick polyacrylamide gel, pH 5-7. It was found that the PGM1*1A frequency was higher in northern China and lower in the south. Phosphoglucomutase (PGM: E. C. 2. 7. 5. 1) occurs in all human tissues and is controlled by four autosomal loci, i.e., PGM1, PGM2, PGM3 [Hopkinson and Harris 1968] and PGM4 [Cantu and Ibarra 1982]. The Polymorphism at the PGM1 locus in human was first revealed in 1964 [Spencer et al 1964]. Since then, extensive studies showed that two codominant alleles, PGM1*1 and PGM1*2, are present on locus PGM1 in all populations, as well as many rare alleles. Investigations with isoelectric focusing (IEF) revealed the presence of four common allotypes, which were previously labelled as PGM1*1+, PGM*1-, PGM*2+, PGMI*2- [Bark et al 1976]. The workshop, held in West Germany in 1985, recommended a new nomenclature: PGM1*1A, PGM1*1B, PGM1*2A and PGM1*2B instead of PGM*1+, PGM1*1-, PGM1*2+ and PGM1*2- in order to avoid misunderstanding [Dykes et al 1985]. A large body of data on the distribution of the four common PGM1 alleles in different populations in the world has been accumulated. But the data on PGM1 in China are yet very limited. The present paper reports the PGM1 gene frequencies in 8 national minorities and 4 subpopulations of Han in China.

Alleles↗
PubMedDate not supplied

Polymorphism of haptoglobin, transferrin and third component of complement in subpopulations of Han ethnic group.

The genetic polymorphisms of haptoglobin, transferrin and third component of complement were investigated by electrophoretic techniques in six subgroups (Harbin, Xi'an, Chengdu, Guiyang, Zhangzhou and Lanzhou) of the Han ethnic group in China. For haptoglobin, HP*1 frequency shows a descending tendency from the South to the North in the Han ethnic group. Among the transferrin alleles, Dchi shows an increasing frequency from the North to the South. For the third component of complement, S allele is absolutely preponderant.

Asian People↗