Developmental abnormalities resulting in short umbilical cord.
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Abnormalities, Multiple↗
Biomedical subjects
R Drut
Publications and source records attributed to R Drut.
Abnormal spleen lobulation and short pancreas.
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Abnormalities, Multiple↗
Adrenal hyperplastic nodules in Wiedemann-Beckwith syndrome.
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Adrenal Cortex↗
Neonatal herpes simplex virus infection diagnosed by cytology of tracheobronchial aspirates.
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Bronchi↗
Cytologic characteristics of congenital mesoblastic nephroma in fine-needle aspiration cytology: a case report.
The cytologic features of congenital mesoblastic nephroma (CMN) as recognized in smears of fine-needle aspirated cytology (FNAC) are reported. These included spindle- and tadpole-shaped cells with round to oval nuclei having small nucleoli and a smooth contour. The cytoplasm of these cells was dense and homogeneously stained. The background was composed of mucoid fibrillar material. The findings appear to be different from other types of renal tumors in infancy and specific enough for this tumor to allow diagnosis by FNAC.
Biopsy, Needle↗
Cystic nephroma: cytologic findings in fine-needle aspiration cytology.
This report presents the fine-needle aspiration cytology (FNAC) findings of a multicystic renal tumor found in a 3-year-old child. The smears contained benign epithelial cells isolated or arranged in sheets of uniform cells strongly suggesting the lining of the cysts. The combination of the imaging data with the FNAC findings favoured the diagnosis of cystic nephroma (CN), a benign renal tumor that is cured by surgery. Surgical pathology confirmed the diagnosis. CN should be added to the list of tumors of the kidney in infancy that appear to be diagnosable by FNAC/biopsy.
Biopsy, Needle↗
Fine-needle aspiration cytology in a case with features of chronic granulomatous disease.
Fine-needle aspiration cytology (FNAC) of enlarged cervical lymph nodes of a 9-yr-old boy complaining of progressive weight loss showed a combination of a necrotizing granulomatous process and pigmented histiocytes. The diagnosis of chronic granulomatous disease (CGD) of childhood was proposed, and it was later confirmed by histology. Although the NBT test was negative, the patient responded well to prolonged bactericidal therapy with trimethoprim-sulfamethoxazole associated with parenteral nutrition, indicating a rare case of CGD with a negative Nitro-Blue Tetrazolium (NBT) test. The cytologic findings appear to be unique for this disease.
Biopsy, Needle↗
Cytologic characteristics of clear-cell sarcoma of the kidney (CCSK) in fine-needle aspiration biopsy (FNAB): a report of 4 cases.
The cytologic findings observed in fine-needle aspiration biopsy (FNAB) of four cases of clear-cell sarcoma of the kidney (CCSK) are reported. Smears contained a monomorphic population of cells exhibiting non-descriptive cytoplasm and almost nude round to oval nuclei with smooth contour, evenly dispersed fine chromatin granules, and one or two small nucleoli. Some nuclei (approximately 40%) had a bar resulting from grooving or folding of the nuclear membrane. Comparison with smears of classical Wilms' tumor and malignant rhabdoid tumor allowed to recognize a distinctive pattern, different from other tumors of the kidney in infancy. The recognition of the CCSK cytologic pattern justifies the usage of aggressive preoperative chemotherapy protocols or the indication of surgery avoiding delays.
Adolescent↗
Pseudosarcomatous myofibroblastic proliferations in the urinary bladder of children.
Ten examples of a pseudosarcomatous myofibroblastic proliferation occurring in the urinary bladder of children (aged 2 to 16 years) are reported. The lesions appeared as polypoid nodular masses of variable size with myxoid and hemorrhagic areas. They consisted of compact fascicles of elongated spindle cells with minimal atypia. Myxoid areas of variable extension and scattered inflammatory cells were constant features, whereas diffuse collagen deposition was not common. Despite the striking cellularity of some of the lesions, most showed minimal mitotic activity. Ultrastructurally, the predominant cells had features of myofibroblasts. Six cases studied by immunocytochemical methods expressed vimentin and muscle-specific actin. In addition, two of these cases expressed desmin and two others cytokeratin. Infiltration into the muscularis propria of the urinary bladder was demonstrated in six cases and into the perivesical soft tissues in two. However, none of the eight patients for whom follow-up information is available has had local recurrence or metastasis develop 18 months to 6 years after surgical excision.
Actins↗
Incidence of childhood cancer in La Plata, Argentina, 1977-1987.
Incidence data on malignant tumors in children aged 0-14 for the period 1977-87 were calculated in La Plata, Argentina. The number of children living in La Plata was 151,085. The overall incidence of malignant tumors was 106.5 per million (127.4 for males and 83.4 for females). Leukemia (30.5%), lymphoma (15.2%) and central nervous system (14.1%) comprised 60% of all tumors. The relative frequency of histologic types was similar to the pattern recognized in other countries of Latin America and different from that reported in North America and Europe where brain tumors rank second. A high incidence of orchioblastoma (infantile embryonal carcinoma) present in this survey can only be substantiated after a longer period of study.
Adolescent↗
Malignant rhabdoid tumor of the kidney diagnosed by fine-needle aspiration cytology.
A case of malignant rhabdoid tumor (MRT) of the kidney diagnosed by fine-needle aspiration cytology (FNAC) in a 4-mo-old infant who later developed a left pleural effusion (also recognized as metastatic disease by cytologic means) is reported. Rhabdoid cells--intermediate-sized cells with vesicular nuclei and prominent nucleoli, exhibiting a paranuclear, eosinophilic, dense inclusion--seem to be specific enough for this tumor to allow diagnosis by FNAC.
Biopsy, Needle↗
Biventricular hypoplasia with myocardial fiber hypertrophy and disarray.
An 8-year-old girl with a long history of cardiac disease had restrictive filling of both ventricles, severe atrioventricular valve regurgitation, and extreme dilation of both atria. At necropsy the inflow areas of both ventricles were small, and part of the left ventricle lacked compact myocardium. Histology revealed myofiber hypertrophy and focal dysplasia (disarray) in both ventricles. The findings suggest an abnormality of cardiac development that occurred before gestation week 5.
Child↗
Mature cystic teratoma of the greater omentum.
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Abdomen, Acute↗
Sclerosing mediastinitis, granulomatous glomerulonephritis, and systemic vasculitis in a child: a unique association.
The association of sclerosing mediastinitis, granulomatous glomerulonephritis and systemic vasculitis found at necropsy of a 9-year-old girl is presented. The histologic findings strongly suggested that the vasculitis played a central role in the development of the sclerosing mediastinitis, which was not associated with granulomas in the mediastinal lymph nodes. The combination of glomerulonephritis, systemic vasculitis, and terminal diffuse pulmonary hemorrhage with acute capillaritis suggests a link between this case and Wegener's granulomatosis, although mediastinitis has not been reported in that disease.
Child↗
Multivisceral dysplastic lesions in a patient with tuberous sclerosis and Langerhans cell histiocytosis.
Collections of large cells and smaller satellite-like cells arranged in an autonomic ganglion-like pattern and resembling the white matter lesions of tuberous sclerosis were found in the thymus, lungs, liver, appendix, and heart of an 8-month-old infant who exhibited other pathologic findings of tuberous sclerosis (rhabdomyomas of the heart and multiple kidney cysts). Focal cytoplasmic staining for S-100 and GFAP was noted in some large cells, suggesting neural (probably schwannian) differentiation. Dysplastic neurogenic foci appearing in internal organs may represent another morphologic marker of tuberous sclerosis. The simultaneous presence of Langerhans cell histiocytosis produced an unusual combination not previously reported.
Appendix↗
[Xanthogranulomatous pyelonephritis in infancy and childhood. Report of two cases].
We are reporting 2 cases of xanthogranulomatous pyelonephritis in boys of 7 and 2 year-old. The inflammatory lesion had extended to perirenal tissues and appeared as a lumbar abscess in case 1. The kidneys affected were diffusely compromised by the lesion. Both cases showed Proteus mirabilis after microbiologic cultures. Definitive diagnosis was done by pathology examination. Nephrectomy was curative.
Abscess↗
Nesidiodysplasia: selection of reliable cell markers.
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Female↗
[Graft-versus-host disease associated with transfusions. Detection of 2 cases by skin biopsy in children].
The first case was a 2 year-old girl with Blackfan-Diamond anemia who developed the immune reaction two weeks after receiving two transfusions of sedimented erythrocytes. HLA typing of lymphocytes showed the presence of three HLA-A, two of which were present in the donors. The second was a newborn who initially received an exchange transfusion and three weeks later another transfusion of whole blood. Both cases exhibited a severe bone marrow involvement and a skin biopsy with the pattern of keratinocyte apoptosis and lymphocyte satellitosis. These histological findings although highly suggestive must be evaluated in the appropriate clinical setting.
Biopsy↗