After 2 weeks of ingestion of 130 g L-Tryptophan a 52 year old female develops an Eosinophilia Myalgia Syndrome with acute onset of deep venous thrombosis of forearm and possible initial cardiac manifestation featuring intermittent sinustachykardia. This is followed by a severe chronic disease (follow-up 15 months) with diffuse scleroderma and sensomotoric polyneuropathia. The deep muscle biopsy-specimen shows mononuclear infiltration of fascia and interstitial myositis with rare eosinophils. A blood eosinophilia (900/ul) occurs only in the initial acute onset of the illness. Plasma level of Kynurenine is significantly high (4000 pmol/ml), collagenneosynthesis is activated (Procollagen type III peptid 0.927 U/ml). No significant clinical improvement was seen with Acathioprine (100 mg/d) and Prednisolon (40-60 mg/d), after treatment with Ciclosporin scleroderma regresses completely, polyneuropathy is persisting.

Biopsy↗

PubMedDate not supplied

[Rare side effects of gold].

Rare side-effects of parenterally administered gold salts in rheumatoid arthritis are reported: metallic gold deposition in the teeth; reversible lymphadenopathies of the neck; IgA loss under gold treatment; gold-induced appearance of ANA and DNA-antibodies and gold deposition in the skin.

Adult↗

PubMedDate not supplied

[Optic immunofluorescence demonstration of monoclonal and polyclonal antinuclear antibodies (ANA) in rheumatoid arthritis (RA) and lupus erythematosus disseminatus (LED)].

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Antibodies, Antinuclear↗

PubMedDate not supplied

[Serum immunoglobulin patterns in rheumatoid arthritis].

Immunoglobulins were estimated quantitatively in sera from patients with rheumatoid arthritis. According to the significantly increased immunoglobulin class(es), in RA patients as compared to normals the following immunoglobulin patterns were registered: IgG pattern, IgM pattern, IgA pattern, IgG-IgM-IgA pattern, IgG-IgM pattern and IgG-IgA pattern. The IgG-, IgA- and IgG-IgM-IgA patterns were predominantly found in sera from patients with seropositive RA. A positive correlation was found between other inflammatory parameters and high titered rheumatoid factor of the IgG-IgM-IgA-, IgG-IgA- and IgM patterns. C-reactive proteins were increased more frequently in seropositive cases and correlated quantitatively with the IgG-IgA-, IgG-IgM-, IgG-IgM-IgA and IgA patterns. Maximal erythrocyte sedimentation rates were accompanied with the IgG-IgA-, IgG-IgM-IgA- and IgG-IgM pattern. The serum complement components C 3 and C 4 were not decreased in neither seropositive nor seronegative RA. The formation of antiglobulins in hypergammaglobulinemic patients with RA induced by an increased immunoglobulin catabolism is suggested as a possible pathogenetic mechanism.

Arthritis, Rheumatoid↗