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Biomedical subjects

R Dolecek

Publications and source records attributed to R Dolecek.

At least 37 records · Page 2Linked to original sources
PubMed1981

Ketotifen in the treatment of diabetics with various allergic conditions.

A study was carried out in 30 hospitalized diabetics suffering from allergic conditions to assess the effects of ketotifen on various laboratory parameters. Ten of the patients were on diet only, 10 on biguanides plus diet, and 10 on sulphonylureas plus diet. Most were overweight. Patients received 4 mg ketotifen daily for 14 days. Oral glucose tolerance tests and other laboratory investigations were carried out before and 7 and 14 days after the start of ketotifen administration. There were no pathological changes measured in blood levels of sodium, potassium, SGPT, SGOT, alkaline phosphatase, cholesterol, triglycerides, creatinine, uric acid, non-protein nitrogen, haemoglobin, haematocrit, white cell count and differential, and platelet count. Glucose tolerance improved somewhat during the repeated oral glucose tolerance test, and there were no significant changes either in the immunoreactive insulin or growth hormone levels during the test. In the diabetics on biguanides, initial blood pressures were raised both in the lying and standing positions. The levels decreased significantly to normal during ketotifen administration. The results indicate that ketotifen can be used without problems in the treatment of diabetics with allergic disorders and its suggested that a long-term study with ketotifen in diabetic patients could be useful.

Biguanides↗
PubMed1980

Endocrine studies with mazindol in obese patients.

Detailed endocrine studies were carried out in 95 hospitalized obese patients during their treatment with diet and the tricyclic anoretic mazindol. The results obtained after 1 week or more of mazindol (2 mg or occasionally 4 mg/day) administration were compared with the results after placebo and with the initial pre-treatment values. There were no significant changes in the following parameters: FSH, LH, testosterone, renin, angiotensin II, growth hormone (GH) levels during insulin tolerance tests (ITT), 131I uptake, basal metabolic rate, Achilles tendon reflexes, T3 RIA, rT3 RIA, 17-ketosteroids and 17-ketogenic steroids in urine, both basal and after stimulation with ACTH and metyrapone. Blood glucose and plasma immunoreactive insulin (IRI) levels during oral glucose tolerance tests decreased during mazindol administration, IRI levels were significantly lower during ITTs after mazindol. T4 RIA serum levels increased significantly after mazindol. When mazindol was administered, GH levels increased somewhat in some obese patients during ITTs, while T3 RIA and rT3 RIA decreased in some patients. Mazindol has not only hunger (appetite) suppressing properties, but it probably affects the metabolism of energy substrates as well. The drug was well tolerated and there were no pathological findings in routine laboratory examinations during a long-term study with mazindol (non-stop treatment for 6 months).

Adolescent↗
PubMed1979

Endocrine response after burn.

The use of radioimmunoassays has made new advances in post-burn endocrine studies possible. The mean fasting IRI plasma (pl.) levels were elevated for 7 weeks, sometimes reaching very high values. During OGTT, an impaired glucose tolerance and insulin resistance could be found. Pl. HGH levels were normal or slightly increased, and their hypoglycemia-caused rise in the first two postburn weeks was blocked. Renin and Angiotensin II pl. levels were high or very high in almost all burned patients. They were very sensitive indicators of burn stress. ACTH pl. levels were in some respects unpredictable: sometimes very high, sometimes only moderately elevated, or normal. There was mostly no correlation between them and the respective 17-OHCS. Serum FSH was uniformly low or very low, while LH was high (25%), normal (31%) or low (44%). Pl. testosterone levels were uniformly very low, except for the first 1-2 postburn days, even in minor burns, their levels returning to normal during convalescence. The response after chorionic gonadotropin was similar. This severe peripheric endocrine gland involvement (burn toxins? impaired circulation?) could be found to some extent when T4 (thyroxine) levels in serum were measured, especially during TSH tests. There was no correlation between TSH and T4 values. The pituitary response (LH, TSH, less FSH) to TRF and LHRH was normal in all patients tested. All the above can have far reaching endocrine and metabolic consequences (catabolism, fuel supply, endocrine priorities), with many new research and therapeutic possibilities.

Adrenocorticotropic Hormone↗
PubMed1977

Aladione (diftalone) in the treatment of subacute thyroiditis.

During 1974 and 1975 thirty patients with subacute thyroiditis referred to us were treated with diftalone (Aladione), a new non-steroidal anti-inflammatory drug, at a daily oral dose of 750 mg. The average treatment lasted 39 days (range 15-100), the mean age of the patients was 43-5 years (range: 22-70). The response to this therapy was prompt and excellent, in no patient was it necessary to switch to any other kind of treatment, such as the corticosteroids. The drug was tolerated very well although among our patients there were two diabetics on insulin and two patients with chronic duodenal ulcer. Following our experience in thirty patients we suggest that diftalone can be considered a treatment of choice in patients with subacute thyroiditis. We also think that during its prolonged administration leucocyte counts and transaminase levels should be regularly controlled.

Adult↗