[Decomposition of free nucleotides in the rat heart, skeletal muscle, brain and liver in oxygen deficiency].
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Biomedical subjects
Publications and source records attributed to R Dierkesmann.
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The endoscopic examination of the tracheobronchial tree is most helpful in the diagnosis and staging of bronchial carcinoma. Tumors that are endoscopically visible may be confirmed in more than 95% of the cases. In localized peripheral tumors, the diagnostic yield of bronchoscopy is significantly lower; for peripheral metastases, only about 10%. In diffuse interstitial pulmonary diseases other than malignancies, some infections, and histiocytosis X, bronchoscopy including transbronchial biopsy is less successful.
A symposium on RCC in July 1998 in Tübingen was where we to reviewed our patients with endobronchial metastatic RCC treated by bronchoscopy since 1981. 24 of 26 consecutive cases are the subject of the present study. Tumor history, X-ray findings, endobronchial appearance, treatment and the pathogenetic mechanisms of this special form of metastatic spread are demonstrated and discussed. In 5 patients > 10 years relapsed between nephrectomy and bronchoscopic tumor therapy. A thrombuslike tumor growth and bleeding were striking bronchoscopic features. In X-ray besides atelectasis, hilar or mediastinal masses were seen half of the patients, in 50% without parenchymal lung nodes, suggesting lymphogenic spread. In several patients bronchial recanalisation could be successfully repeated over long periods. Abnormal X-ray, haemoptysis or dyspnoa in patients with RCC demands bronchoscopy. In case of bronchial tumor obstruction bronchoscopic treatment offers excellent palliation.
In extrapulmonary tuberculosis, infectiousness can be considered negligible. The number of viable organisms in the sputum of patients with pulmonary tuberculosis decreases markedly during chemotherapy in the first 2 weeks but they retain their pathogenicity; therefore, patient with sputum-positive tuberculosis cannot be regarded as non-infectious. Outpatient treatment can be recommended only if the patient is isolated at home and the intake of the prescribed drugs is guaranteed. An increasing rate of susceptible people are to be expected in the future. Measures for controlling the infection continue to be mandatory.
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