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Biomedical subjects

R Diaz

Publications and source records attributed to R Diaz.

At least 145 records · Page 8Linked to original sources
PubMed1977

Procainamide-induced systemic lupus erythematosus with hypocomplementemia.

Procainamide-induced systemic lupus erythematosus (SLE) is a well recognized clinical syndrome believed to be characterized by normocomplementemia. However, in 7 cases of drug-induced SLE recorded in the literature, hypocomplementemia was found. The present report concerns a well documented case of procainamide-induce SLE with hypocomplementemia. The patient improved and complement values returned to normal after procainamide therapy was discontinued and replaced by digitalis and steroid therapy.

Aged↗
PubMed1976

Supra-operonic clustering of genes specifying glucose dissimilation in Pseudomonas putida.

The linkage arrangements of genes governing glucolysis in Pseudomonas putida have been determined by transductional analysis. Five genes (gdh, kgtA, kgtB, edd and eda), comprising at least three operons, are contransducible with each other, but not with ggu (glucose and gluconate uptake) nor with genes of a known supra-operonic cluster of genes specifying enzymes of other dissimilatory pathways, nor with a biochemically uncharacterized his marker. It thus appears that P. putida may have more than one chromosomal region in which genes with dissimilatory function are clustered in a supro-operonic fashion.

Gene Frequency↗
PubMed1976

Endotoxic activity of rough organisms of Brucella species.

A rough-specific antigen extracted from the rough species Brucella ovis and lipopolysaccharide extracted from smooth Brucella abortus demonstrated equivalent levels of activity in tests for mouse lethality and limulus lysate clotting activity. Acetone-extracted whole cells of B. ovis and of B. canis and of a rough mutant of B; abortus had the same toxicity for mice, but it was not possible to extract endotoxin from B. canis by the methods used.

Animals↗
PubMed1975

Effects of dobutamine on atrioventricular conduction.

Dobutamine, a new beta-stimulating catecholamine, has been investigated in terms of its effect upon atrioventricular conduction. Bundle of His recordings were obtained on six patients in basal conditions and with right atrial pacing at rates of 100, 120, and 140 per minute. Recordings were repeated following intravenous administration of Dobutamine in doses of 5, 10, and 15 mug per kilogram per minute. Dose-response curves were thus obtained for A-H and H-V intervals. Heart rate increased only moderately with progressive concentrations of the drug. Very significant facilitation of A-H conduction was demonstrated with doses of 10 and 15 mug per kilogram per minute, with no effect upon H-V times. Dobutamine may be a clinically useful inotropic agent in conditions associated with A-V conduction disturbances.

Adult↗
PubMed1975

Haemodynamic effects of a new inotropic agent (dobutamine) in chronic cardiac failure.

The haemodynamic effects of dobutamine were studied in 14 patients with chronic congestive cardiac failure. Heart rate, central venous, pulmonary arterial, pulmonary wedge, and aortic pressures, aortic dp/dt, cardiac output, cardiac index, stroke volume, and pulmonary and systemic vascular resistances were measured or derived. Dose-response curves were obtained by recording all measurements before and after intravenous infusion of dobutamine at rates of 2.5, 5, and 10 mug/kg per min for periods of 30 minutes each. Significant increases in mean values were observed for cardiac output from 3.7 to 6.4 l/min (82%), for stroke volume from 44 to 64 ml (39%), and aortic dp/dt from 692 to 1414 mmHg/s (92.0 to 188.1 kPa/s (76%). Heart rate increased only moderately from 86 to 101 per minute (31%). Significant reduction occurred in pulmonary wedge and central venous pressures. Mean aortic and pulmonary pressures did not change significantly, as a measure of decreased vascular resistances. The drug was uniformly well tolerated. The predominant inotropic effects of dobutamine without tachycardia or arrhythmias may be valuable in severe heart failure.

Adult↗