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Biomedical subjects

R Di Carlo

Publications and source records attributed to R Di Carlo.

At least 55 records · Page 3Linked to original sources
PubMed1984

Modifications in prolactin binding capacity in the rat liver induced by non-steroidal anti-inflammatory drugs.

Modifications in prolactin specific binding in the rat liver induced by different non-steroidal anti-inflammatory drugs (indomethacin, piroxicam, ketoprofen, phenylbutazone, mefenamic acid and acetylsalicylic acid) have been studied. All caused a dose-dependent inhibition of prolactin binding capacity whereas no change was found in dissociation constant values. The inhibitory effect is reversible and highly specific, since insulin binding to the same membrane preparation is not affected. The degree of inhibitory activity on prolactin binding is related to the anti-inflammatory activity of each drug, which supports the hypothesis of an involvement of prostaglandin synthesis.

Animals↗
PubMed1983

Physiological and pharmacological variations in rabbit prolactin plasma levels.

By using a specific homologous double-antibody RIA, physiological and pharmacological variation in prolactin plasma levels were studied in the rabbit. The study of plasma levels during 24 h period demonstrated the presence of a rhythmic secretion of prolactin with higher values between 15.00 and 19.00 h. Prolactin plasma levels were low in neonatal rabbits and increased gradually with the age of the animals. In adult rabbits a significant higher prolactin plasma concentration was found in female animals. Blood levels fluctuate during the first half of pregnancy but the mean levels were higher than those found during the second half of gestation. A remarkable increase of plasma levels was observed 24 h before parturition and during lactation. Plasma prolactin concentrations increased after injection of both chlorpromazine and sulpiride. The hyperprolactinaemic effect of sulpiride was abolished by bromocriptine.

Age Factors↗
PubMed1981

Histology and cytometrics in human breast cancers assayed for the presence of prolactin receptors.

Histology and cytometrics were evaluated in 50 cases of human breast infiltrating carcinomas (44 ductal, 6 lobular) assayed for the presence of prolactin receptors (PR). The tumors were considered PR positive when the level of specific binding reached or exceeded 0.5%. Twenty-six ductal infiltrating carcinomas and 4 lobular ones were PR positive. No strict correlation was found between PR and degree of histologic differentiation (expressed in grades) or menopausal status. Better differentiated (grade I) ductal carcinomas were, however, mostly PR negative. Evaluation of the mean nuclear diameter (MND) and of the maximal epithelial cellularity (MEC) revealed that in ductal carcinomas a high level of PR (greater than 3% specific binding) was significantly correlated with a high MND. It is concluded that, contrary to that observed in estrogen receptor-positive tumors, PR-positive human ductal carcinomas are more likely to have large nuclei, i.e., cytologically anaplastic, whereas better differentiated (grade I) carcinomas are generally PR negative.

Breast Neoplasms↗
PubMed1981

Pharmacological researches on 2-(7'-theophyllinemethyl)1,3-dioxolane.

The main pharmacological activities of 2-(7'theophyllinemethyl)-1,3-dioxolane (ABC 12/3), a new theophyllinic derivative, were studied. This compound was shown to possess an extremely high anti-bronchospastic activity in vitro and in vivo, its effectiveness being much greater than that of theophylline; and it also showed a strong activity as an antitussive on experimental cough induced by citric acid or histamine aerosol. However the compound showed little activity on the intestinal smooth muscle, the cardiovascular and the central nervous systems. The acute toxicity of ABC 12/3 is rather low and therefore it should be possible to utilize it for therapeutic purposes in tracheobronchial diseases.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1979

Prolactin receptor in human mammary carcinoma.

The specific binding of labelled human prolactin was determined in 83 human breast carcinomas. Twenty-seven tumors (32.5%) contained specific binding for prolactin of at least 1% and were considered prolactin receptor positive. The binding was found linearly related to membrane protein concentration and specific only for lactogenic hormones. By Scatchard analysis the dissociation constant appeared similar to that observed in other target tissues, with a low binding capacity.

Breast Neoplasms↗
PubMed1977

[Derivatives of 1,3-bis-(methlendioxyphenoxy)propane with antispastic activity].

A number of amines derived from 1,3-bis(3,4-methylen-dioxyphenoxy)propane have been prepared from 1,3-bis-(3,4-methylendioxy-phenoxy)propan-2-one. The acute toxicity and the activity of these compounds on isolated guinea pig ileum have been studied. The majority of the compounds showed clear antagonist activity towards BaCl2, histamine and acetylcholine contracting responses, generally grater than that of papaverine; on the contrary, their antagonist activity towards 5-HT responses was slightly lower.

Acetylcholine↗
PubMed1975

[Action on the isolated guinea-pig ileum and toxicity of some derivatives of 1,5-bis-(3,4-methylendioxyphenyl)-n. pentane].

The acute toxicity and the activity on isolated guinea pig ileum of some derivatives of 1,5-bis-(3,4-methylendioxyphenyl)-n.pentane are reported. The majority of such compounds showed clear antagonist activity towards BaCl2, acetylcholine, histamine and 5-HT contracting responses, generally greater than that of papaverine. In almost all cases the therapeutic index of these compounds, calculated as the ratio between mouse i.v. LD50 and ileum ED50, was greater than the therapeutic index of papaverine.

Amines↗