[Finger ulcers in the course of a carpal tunnel syndrome with Raynaud's syndrome].
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Biomedical subjects
Publications and source records attributed to R Desproges-Gotteron.
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A 53-year-old woman developed symmetrical polyneuropathy of the lower limbs a few months after she was found to have myeloma with cryoglobulinemia. In musculocutaneous nerve biopsy material, electron microscopy showed both axonal degeneration and demyelination. The most striking finding was the presence, in the endoneurial space, of numerous masses of closely packed tubular structures. These masses also were found in the walls of all the vasa nervorum and within the lumen of some vessels. The morphological features and dimensions of the deposits within nerve were identical to those of cryoprecipitates extracted from serum and examined with the electron microscope. An example of myeloma neuropathy with cryoglobulin deposits within the endoneurial space has not been reported previously.
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The authors report 3 cases of chronic atrophic polychondritis with clinical signs characteristic of the disease. The 3 patients had deafness of perceptive type, very severe in one case. In one case, the relationship between inflammatory rheumatism and rheumatoid arthritis is discussed. The 3 cases include a pathological study under the electron microscope of the cartilage of the ear. Certain ultrastructural peculiarities observed (dense perichondrocyte granules) are compared with the data in the literature.
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