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Biomedical subjects

R Depieds

Publications and source records attributed to R Depieds.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Suppressor cells in allergic encephalomyelitis].

The induction of EAE in Lewis rats by basic protein (BP) is suppressed by the transfer of non-draining lymphnode cells from cured animals. The activation of draining lymphnode cells of these cured animals by BP, PHA or ConA is decreased with the addition of non-draining lymph node cells from the same rats.

Animals↗
PubMedDate not supplied

[Regulation of lymphocyte responses in vitro: inhibitory effects of rat serum].

Previous results on the potentiation by cytochalasin B (CB) of lymphocte responses in vitro, particularly the requirement for serum for this potentiation, prompted us to undertake the present study on inhibitory effects of autologous serum on rat lymphocyte activities. Main results mirror the inverse effect of CB: maximal inhibition is obtained at suboptimal doses of PHA; inhibitory effect bears essentially on early events of activation; high cell density is of prime importance. In contrast to CB, serum affects more 3H-TdR incorporation than blast transformation. Therefore, CB and some serum component(s) could have inverse effects on a single regulatory mechanism: suppressive cellular interactions.

Animals↗