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Biomedical subjects

R Dell'Acqua

Publications and source records attributed to R Dell'Acqua.

13 recordsLinked to original sources

Spatial attention freezes during the attention blink.

A variant of the rapid serial visual presentation paradigm was used to display sequentially two lateral sequences of stimuli, one to the left and one to the right of fixation, embedding two pairs of target stimuli, T1 and T2. T1 was composed of a pair of alphanumeric characters, and subjects had either to ignore T1 or to encode T1 for a delayed response. T2 was a lateral square of a prespecified color. The square had a small gap in one side, and the task for this stimulus was to report which side had the gap. When subjects were required to ignore T1, the T2-locked ERP produced a clear N2pc, that is, a greater negativity at electrode sites contralateral to the position occupied by T2. This N2pc was followed by a sustained posterior contralateral negativity (SPCN). When subjects were required to monitor T1 in addition to T2, both the N2pc and the SPCN components amplitude depended on the difficulty of the task associated with T1. If T1 was composed of digits that had to be encoded for a delayed same/different judgment, both the N2pc and the SPCN components were entirely suppressed. Although attenuated, such components were present when T1 was composed of a pair of symbols that subjects could disregard. The results suggest that a set of mechanisms subserving the allocation of attention in the spatial domain, resulting in the N2pc, suffer significant interference from concurrent cognitive operations required to encode information into visual short-term memory.

Adult↗

Four-dot masking produces the attentional blink.

When two target stimuli (T1 and T2) are presented sequentially within half a second of each other, identification accuracy is often poor for T2. This phenomenon, known as attentional blink (AB), can be observed generally only if the stimulus terminating the presentation of T2 acts as an interruption mask. Recent evidence suggests that even four small dots surrounding a target item can exert masking effects, provided the target onset occurs at an unattended spatial location. In order to test whether an AB could be observed under conditions of four-dot masking of T2, five rapid serial visual presentation streams of letters were synchronously displayed on each trial of the present experiment. T1 and T2 were digits presented at unpredictable locations and unpredictable temporal intervals. T2 was followed by either a blank field, a letter, or four-dots. No AB was observed when T2 was not masked, but robust and equally sized ABs were observed when T2 was followed by both the letter mask and the four-dots.

Adult↗

Electrophysiological evidence of visual encoding deficits in a cross-modal attentional blink paradigm.

Two experiments are reported in which two target stimuli, T1 and T2, were presented at variable stimulus onset asynchronies (SOAs). In Experiment 1, T1 and T2 were visual stimuli embedded in a rapid serial visual presentation (RSVP) stream of distractors. Participants were asked to report T1 and T2 at the end of the stream. In Experiment 2, T1 was an auditory stimulus, and T2 a visual stimulus embedded in an RSVP stream. Participants made a speeded discriminative response to T1, and reported T2 at the end of the stream. An attentional blink (AB) effect was observed in both experiments: T2 report suffered at short SOA compared to long SOA. During the AB, the amplitude of the P300 component of the event-related potential (ERP) locked to T2 onset was sensibly reduced in both experiments. Behavioral and ERP results were very similar across the two experiments. Implications for models of the AB effect are discussed.

Attention↗

Selective effect of closed-head injury on central resource allocation: evidence from dual-task performance.

Two dual-task experiments are reported bearing on the issue of slower processing time for severe chronic closed-head injury (CHI) patients compared to matched controls. In the first experiment, a classical psychological refractory period (PRP) paradigm was employed, in which two sequential stimuli, a pure tone and a colored dot, were presented at variable stimulus onset asynchronies (SOAs), each associated with a distinct task. The task on the tone required a speeded vocal response based on pitch, and the task on the colored dot required a speeded manual response based on color. In the second experiment, either one or three masked letters was presented, followed by a pure tone at variable SOAs. The task on the letters required a delayed report of the letters at the end of each trial. The task on the tone required an immediate manual response based on pitch. In both experiments, both CHI patients and matched controls reported an SOA-locked slowing of the speeded response to the second stimulus, a PRP effect. The PRP effect was more substantial for CHI patients than for matched controls, suggesting that a component of the slower processing time for CHI patients was related to a selective increase in temporal demands for central processing of the stimuli.

Acoustic Stimulation↗

Cross-modal attentional deficits in processing tactile stimulation.

In order to substantiate recent theorization on the possible links between the causes of the attentional blink and the psychological refractory period phenomena (e.g., Jolicoeur, 1999a), four experiments are reported in which two target stimuli, T1 and T2, were presented in different modalities at varying stimulus onset asynchronies (SOAs), with each stimulus being associated with a distinct task, Task1 and Task2. In Experiment 1, T1 was a tone, and Task1 was a speeded vocal response based on pitch. T2 was a brief press applied to either of two distal fingerpads, and Task2 was a speeded manual response based on tactile stimulus location. In Experiment 2, the same T1 as that used in Experiment 1 was presented, and in Task1 the subject either made a speeded vocal response based on pitch or ignored T1. T2 was a masked tactile stimulation, and Task2 was an unspeeded manual discrimination of the tactile stimulation location. This Task2 was maintained in Experiments 3 and 4. The auditory T1 was replaced with a white digit embedded in a rapid serial visualization presentation of a stream of black letters, and in Task1 the subject either made an unspeeded decision based on T1 identity or ignored T1. In all the experiments, the results showed an SOA-locked impairment in Task2. As SOA was decreased, reaction times in the speeded Task2 of Experiment 1 increased, and accuracy in the unspeeded Task2 of Experiments 2-4 decreased. The SOA-locked impairment was almost eliminated when T1 could be ignored or was absent. The results are discussed in terms of central processing limitations as the cause of such effects.

Adult↗

Naming times and standardized norms for the Italian PD/DPSS set of 266 pictures: direct comparisons with American, English, French, and Spanish published databases.

The present study provides Italian normative measures for 266 line drawings belonging to the new set of pictures developed by Lotto, Dell'Acqua, and Job (in press). The pictures have been standardized on the following measures: number of letters, number of syllables, name frequency, within-category typically, familiarity, age of acquisition, name agreement, and naming time. In addition to providing the measures, the present study focuses on indirect and direct comparisons (i.e., correlations) of the present norms with databases provided by comparable studies in Italian (in which normative data were collected with Snodgrass & Vanderwart's set of pictures; Nisi, Longoni, & Snodgrass, 2000), in British English (Barry, Morrison, & Ellis, 1997), in American English (Snodgrass & Vanderwart, 1980; Snodgrass & Yuditsky, 1996), in French (Alario & Ferrand, 1999), and in Spanish (Sanfeliu & Fernandez, 1996).

Adult↗

Visual encoding of patterns is subject to dual-task interference.

Two stimuli were presented at varying stimulus onset asynchronies (SOAs), with each stimulus associated with a distinct task. The first stimulus was a tone at one of either two or three frequencies. In two conditions, the task associated with a tone was either a speeded two-alternative discrimination (2AD), or a speeded three-alternative discrimination (3AD) based on the pitch of the tone. In a third condition, subjects were told to ignore the tone. The second stimulus was a briefly exposed study matrix of red and black squares followed by a mask. After a fixed delay, the mask was replaced by a test matrix that was either the same or different from the study matrix. The task associated with the matrices was to indicate, with no speed pressure, whether the study matrix and the test matrix were the same or different. Results from each speeded AD condition showed that subject's accuracy in the matrix task decreased as the SOA between the tone and the study matrix decreased. This effect was larger for the 3AD tone task than with a 2AD tone task. In addition, within each speeded AD condition, longer RTs in the tone task were associated with lower accuracy in the matrix task. None of these effects was evident when the subjects were told to ignore the tone. These results suggest that encoding visual information can be subject to significant capacity limitations imposed by cross-modal multitasking.

Adult↗

Selective influence of second target exposure duration and task-1 load effects in the attentional blink phenomenon.

The purpose of the experiments was to constrain the locus of interference in the attentional blink (AB) paradigm. Two visual stimuli, T1 and T2, were shown 300 msec apart, and each was followed by a mask. T1 was an "H," an "S," an "&," or a blank field; T2 consisted of five letters. In Task1, blank fields and & characters could be ignored, whereas Hs and Ss had to be identified and reported. Task2 was always to report as many letters as possible from T2. Task2 performance was lower when T1 had to be reported, as expected from the attentional blink phenomenon (AB). The exposure duration of T2 was also manipulated. More letters could be reported as exposure duration was increased. However, this effect was additive with manipulations of Task1 processing load that produced the AB effect. Log-linear analyses assuming that effects of T2 exposure duration and Task1 load effects occur at functionally distinct stages of processing provided satisfactory fits to the results, suggesting that none of the AB effect occurs as early as those of T2 exposure duration. The results suggest that the locus of the AB effect is later than the stage(s) of processing affected by exposure duration.

Adult↗

Unconscious semantic priming from pictures.

Three experiments examined the effects of unconsciously presented picture primes on semantic categorization and naming responses to both word and picture targets. Picture naming and word categorization responses to targets were faster and more accurate when the picture primes belonged to the same semantic category as the targets, so called priming effect. No priming was found when subjects performed a word reading task. When priming was evident, no difference was found between responses to targets that were nominally identical to primes (e.g. the picture of a lion followed by either the word LION or the picture of a lion) compared with nominally different targets from the same semantic category as the primes (e.g. the picture of an ELEPHANT followed by either the word LION or the picture of a lion). Responding did not differ significantly from chance when subjects were asked to categorize the primes as natural objects vs. artifacts or as meaningful vs. meaningless objects in three distinct forced-choice unspeeded tasks.

Adult↗

The demonstration of short-term consolidation.

In a dual-task paradigm, a visual display (T1) containing characters (letters or symbols) was presented first, followed by an auditory signal (T2) at various stimulus-onset asynchronies (SOAs). A speeded response to T2 was required. When the information in T1 had to be recalled later, response times to T2 (RT2) were elevated at short SOAs and decreased as SOA was increased. The effects on RT2 were larger when there were more items to be remembered. We interpreted the results as evidence that encoding information into short-term memory (STM) involves a distinct process, which we call short-term consolidation (STC). The results suggested that STC has limited capacity and that it requires central processing mechanisms. Additional evidence suggested that no memory for T1 was formed in STM when STC was not engaged.

Adult↗

In vivo and in vitro HeNe laser effects on phagocyte functions.

The goal of this work was to evaluate the effect of helium-neon (HeNe) laser irradiation on immunocompetent cells. We used the in vivo skin window method and in vitro granulocyte function tests. The study of cellular migration showed a marked decrease in vitro and in vivo in a dose-independent manner. Superoxide release was not modified by laser irradiation. The granulocyte's aggregation, when using PHA and PMA, presented a reduction that was statistically very significant, not as a subordinate dose. An increase of the release of ATP was demonstrated only at 4 joules and precedes granulocyte aggregation. When using Ca2+ ionophore A23187 as stimulus, laser irradiation at 1, 2 or 4J did not show any modification of granulocyte aggregation. The monoclonal antibody 60.1, which identifies a membrane antigen fundamental for aggregation and chemotaxis, is expressed in normal amounts on granulocyte membranes both before and after irradiation with a HeNe laser. In fact, Laser irradiation preferentially attacks the area of the cellular centrosome that determines a modification of cellular morphology. The electron microscope and immunofluorescence study with a monoclonal antibody have pointed out a disorganization of the microtubules. The alteration of some of the granulocyte functions is correlated to the damage in the centrioles. The granulocyte mitochondrial system and surface membrane remain intact, and this explains the normal production and release of free radicals. Further experiments are necessary to evaluate the clinical application of lasers in various diseases with immunophagocytic pathogenesis.

Adenosine Triphosphate↗

Skin involvement in hemopathies: specific cutaneous manifestations of acute nonlymphoid leukemias and non-Hodgkin lymphomas.

The course of a hemopathy may be characterized by the appearance of cutaneous lesions. In such cases a correct histological investigation is needed, especially when the lesions have an aspecific appearance. It is important, therefore, to recognize the cases characterized by cutaneous involvement of typical systemic disease cells. Lymphomas and leukemias are the hemopathies which more frequently present specific and nonspecific cutaneous manifestations (with an approximate incidence of 3-40 and 6-50%, respectively). In the period 1977-1983 we examined 337 patients affected with acute nonlymphoblastic leukemia and 243 patients affected with non-Hodgkin lymphoma, in order to verify the incidence of specific cutaneous manifestations.

Acute Disease↗